To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.


Friday, April 27, 2007

The validity of the laboratory marker combinations DOVER and QUVER to detect physician’s diagnosis of at-risk drinking
Addiction Biology 12 (1), 85–92.

Especially in situations where it might be favorable for the patient to dissimulate the existing alcohol problem, ‘objective’ laboratory tests can be helpful.

In this study we report validation of the two combinations DOVER (DOctor VERified) and QUVER (QUestionnarie VERified) of the biological markers percent carbohydrate-deficient transferrin (%CDT) and gamma-glutamyl-transferase (γ-GT) to detect patients that have been identified by their physicians with at-risk drinking behavior.

Our analysis demonstrated that the combination of the markers γ-GT and %CDT with the physician’s judgement of the condition as reference was superior to the use of single markers.