Dietary Patterns, Supplement Use, and the Risk of Symptomatic Benign Prostatic Hyperplasia: Results from the Prostate Cancer Prevention Trial
American Journal of Epidemiology Advance Access published online on February 7, 2008


This study examined dietary risk factors for incident benign prostatic hyperplasia (BPH) in 4,770 Prostate Cancer Prevention Trial (1994–2003) placebo-arm participants who were free of BPH at baseline.

BPH was assessed over 7 years and was defined as medical or surgical treatment or repeated elevation (>14) on the International Prostate Symptom Score questionnaire. Diet, alcohol, and supplement use were assessed by use of a food frequency questionnaire.

There were 876 incident BPH cases (33.6/1,000 person-years). The hazard ratios for the contrasts of the highest to lowest quintiles increased 31% for total fat and 27% for polyunsaturated fat and decreased 15% for protein (all p_trend <> of alcoholic beverages (0 vs. 2/day: hazard ratio (HR) = 0.67) and vegetables (<1 alt="≥" src="/math/ge.gif" border="0">4/day: HR = 0.68) and higher in daily (vs. <1/week) hr =" 1.38)."> no associations of supplemental antioxidants with risk, and there was weak evidence for associations of lycopene, zinc, and supplemental vitamin D with reduced risk.

A diet low in fat and red meat and high in protein and vegetables, as well as regular alcohol consumption, may reduce the risk of symptomatic BPH.


<sup>Read Full Abstract


Request Reprint E-Mail:</sup> akristal@fhcrc.org ).
^{__________________________________________________________________________________}