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Monday, January 9, 2012

Different independent susceptibility markers for first-ever cerebral infarction and myocardial infarction in young patients

Cerebral infarction (CI) and myocardial infarction (MI) share some common features, but there are other differences in risk factors.

The aim of our study is to determine whether there are some significantly independent susceptibility markers for them.

All consecutive patients between the ages of 18 and 45 years with first-ever CI and MI during 2001–2010 were recruited to participate in the study. Using multivariate logistic regression modeling, we explore many different data, such as age at onset, sex ratio, numbers of patients with history of hypertension, smoking, drinking, and serum lipid, uric acid, prealbumin (PA), and white blood cell (WBC) count levels.

Logistic regression analysis adjusted for confounders confirmed the following independent susceptibility markers for young CI patients: hypertension, admission serum PA levels, daily alcohol [odds ratio (OR), 0.251; 95% confidence interval (CI), 0.097–0.648,
p = 0.004; OR, 0.994; 95% CI, 0.988–0.999, p = 0.031; OR, 0.150; 95% CI, 0.047–0.473, p = 0.001], and for MI patients: age at onset, current smoking, serum WBC, and glucose levels (OR, 1.293; 95% CI, 1.146–1.457, p = 0.000; OR, 8.914; 95% CI, 3.575–22.231, p = 0.000; OR, 1.344; 95% CI, 1.169–1.544, p = 0.000; OR, 1.149; 95% CI, 1.022–1.291, p = 0.020).

We conclude that there are some significantly different independent susceptibility markers for young CI and MI patients.

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