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Wednesday, July 1, 2009

Decreased somatostatin is related to the hypersensitivity of intestinal epithelia to LPS via upregulated TLR4–TBK1 pathway in rats chronically exposed to ethanol
Alcohol Volume 43, Issue 4, June 2009, Pages 293-303

Chronic alcoholics are predisposed to the development of a systemic inflammatory response syndrome, which is usually triggered in the gut. This study aimed to investigate in rats the role of intestinal epithelial inflammatory responsiveness in the susceptibility of alcoholics to excessive inflammation.

These findings suggest that impairment of intestinal SST production by chronic ethanol administration leading to upregulation of the TLR4–TBK1 pathway may be one of the mechanisms underlying the LPS hypersensitivity of intestinal epithelia.

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