Alcohol Tolerance: Contribution to Consumption (R01)Request For Applications (RFA) Number: RFA-AA-08-009Release date: 16 January 2008
Expiration Date: 26 March , 2008
This Funding Opportunity Announcement (FOA) issued by the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, solicits Research Project Grants (R01s) that propose to determine the significance of tolerance to alcohol induced responses and the risk for alcohol abuse and alcohol dependence.
It is well established that tolerance develops to the effects of alcohol. In fact, tolerance is one of several criteria used for diagnosing alcohol dependence according to DSM IV. However the consequences of alcohol tolerance for health and for the development of alcohol dependence have not been determined. Tolerance may permit greater consumption of alcohol as a consequence of reduced adverse response to alcohol. Consequently with greater alcohol consumption greater tissue damage would result. In addition the greater consumption permitted by alcohol tolerance may influence the development of alcohol dependence. In order to establish the relevance of tolerance for development of treatments for prevention of relapse or treatment of alcohol dependence, the significance of tolerance to alcoholism needs to be clarified.
Extensive studies have been carried out on alcohol-induced tolerance and have demonstrated that alcohol tolerance is a complex phenomenon that encompasses a wide range of alcohol-induced responses and a multitude of distinct processes. The emphasis of this funding opportunity announcement focuses on the relationship between tolerance to alcohol induced response and increased risk for alcohol dependence or relapse. Once such a link is established, the mechanism of tolerance can be explored for those specific responses predicting or associated with dependence or relapse.
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