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Monday, March 26, 2007

Chronic Alcohol Consumption Is Associated With Changes in the Distribution, Immunophenotype, and the Inflammatory Cytokine Secretion Profile of Circulating Dendritic Cells

Alcoholism is frequently associated with altered immune responses, limited information being available on its effects on dendritic cells (DC). In the present study we analyze the effects of chronic alcoholism on circulating DC.

Chronic alcoholism in the absence of liver disease is associated with an increased secretion of inflammatory cytokines by PB DC, whereas ALCAW and ALCET patients show decreased numbers of circulating DC and reduced secretion of these cytokines, respectively.


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