Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Wednesday, April 18, 2007

NEWS ALERT A few brief meetings with healthcare workers can curb excessive drinking in men
18 APRIL 2007

Between one and four standard appointments with a general practitioner or nurse can reduce a patient’s alcohol consumption by an average of five standard drink units a week, according to a Cochrane Review. The effect of brief advice about alcohol is more pronounced in men and a year later, they still had significantly reduced alcohol consumption. There is, however, less evidence that this approach helps curb excessive alcohol intake in women.

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Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: Five monoamine genes
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Early View On-line 17 April 2007


Association analysis has suggested that common sequence variants of genes that affect monoamine function can affect substance use and abuse. Demonstration of these associations has been inconsistent because of limited sample sizes and phenotype definition.

Drawing on the life course perspective, we predicted a stronger association between the polymorphisms in 5HTT, DAT1, DRD4, DRD2, and MAOA and alcohol consumption in young adulthood than adolescence.

All five genes are significantly associated with the frequency of alcohol consumption, with the genotype effects ranging 7%-20% of the mean score of alcohol consumption and their P values being 0.014, 0.0003, 0.003, 0.007, 0.005, and 0.003, respectively.

The association is only observed in the life stage of young adulthood and not in adolescence. This analysis has demonstrated the potential usefulness of the life course perspective in genetic studies of human behaviors such as alcohol consumption.

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REPRINT REQUEST E-MAIL: guang_guo@unc.edu.
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Tuesday, April 17, 2007

Group of House Republicans Push for Beer Tax Apr-12-2007 11:41




For nearly 30 years, the state beer tax has been $2.60 per 31-gallon barrel, or eight-tenths of one-cent per bottle.

(SALEM) - A group of House Republicans wants a nickel-a-beer tax increase to help pay for 300 more state troopers, the Ashland Daily Tidings reported.

Reps. Sal Esquivel of Medford, Brian Boquist of Dallas and Wayne Krieger of Gold Beach want to give the Oregon State Police a dedicated funding source outside of the state's general fund, partly so the department can resume around-the-clock patrols.

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Drinks With Youth Appeal Draw Growing Opposition

Published: April 13, 2007

SACRAMENTO — Three years ago, at the age of 15, Jimmy Jordan says, he got his first taste of what it was like “to be cool and fit in.” While watching a video with friends, a buddy urged him to try a Smirnoff Ice, one of dozens of flavored alcoholic beverages that look and taste like soda but offer the kick of a cocktail.

Speaking to a state board in February, Elianna Yanger, 17, of California Friday Night Live, said that similar packaging of an energy drink, left, and a malt beverage showed an effort to market alcohol to teenagers.

Jimmy Jordan, a high school senior in California, is campaigning against beverages known as alcopops that are popular with young drinkers.

. . . . READ FULL ARTICLE
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THE IMPACT OF SELF-HELP GROUP ATTENDANCE ON RELAPSE RATES AFTER ALCOHOL DETOXIFICATION IN A CONTROLLED STUDY

Alcohol and Alcoholism 2007 42(2):108-112




Self-help groups such as Alcoholics Anonymous (AA) are widely recommended for aftercare of alcohol-dependent persons, even though scientific knowledge of its effectiveness is inconsistent.

The aim of the present analysis was to elucidate whether persons attending AA groups regularly after detoxification have lower relapse rates within 1 year, compared to person without self-help group attendance.

The present study was unable to show an advantage of self-help group attendance in reducing relapses compared to the control group.

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REPRINT REQUEST E-MAIL: sandra.mueller@upkbs.ch

Contributor: Don Phillips
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FAMILY FIRST'S 10-POINT PLAN TO REDUCE AUSTRALIA'S ALCOHOL TOLL
MEDIA RELEASE
SF/125 Monday April 16, 2007


Australia has a drinking problem. Alcohol is a legal substance which is killing Australians, particularly young Australians, and FAMILY FIRST is today launching a campaign to reduce the alcohol toll.
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Alcoholic cerebellar degeneration: A clinicopathological study of six Japanese autopsy cases and proposed potential progression pattern in the cerebellar lesion

Neuropathology
Volume 27 Issue 2 Page 99 - April 2007


Alcoholic cerebellar degeneration (ACD) is one of the most common neurological complications in alcoholics. As far as we know, however, only four Japanese autopsy cases of ACD have been reported, and only limited clinicopathological data on this disease are now available in Japan.

The aims of this study were: (i) to examine the clinicopathological correlation of six Japanese autopsy cases of ACD, including three asymptomatic cases; and (ii) to elucidate the pattern of progression of the cerebellar lesion in ACD.

These findings suggest that in ACD, severe lesions successively develop: (i) in the anterior superior vermis; (ii) anterior superior hemisphere; (iii) anterior inferior hemisphere; and (iv) anterior inferior vermis.

In addition, cerebellar symptoms may frequently occur if the anterior superior hemisphere and anterior inferior hemisphere, in addition to the anterior superior vermis, are involved.

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REPRINT REQUEST E-MAIL: oyokota1@yahoo.co.jp
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CONFERENCE: Alcohol in the Atlantic World: Historical and Contemporary Perspectives

Oct 24, 2007 to Oct 27, 2007

This International Workshop on Alcohol in the Atlantic World: Historical and Contemporary Perspectives is an assembly of established researchers and new scholars examining alcohol throughout the Atlantic World from a variety of historical and contemporary perspectives and disciplinary traditions.

The geographic focus of the workshop is Africa, the Americas, the Caribbean and Europe within the context of the Atlantic world. Its major themes include, but are not limited to, production, trade and consumption.


Location: Founders College
Sponsor: Harriet Tubman Resource Centre on the African Diaspora
Posted by: José C. Curto and David V. Trotman
Web Site: http://www.yorku.ca/nhp/conferences/2007/york_2007/index.htm


Source: Alcohol and Drug History Society
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Testing association in the presence of linkage - a powerful score for binary traits
Genetic Epidemiology
Early View Published Online 13 April 2007



We present a score for testing association in the presence of linkage for binary traits. The score is robust to varying degrees of linkage, and it is valid under any ascertainment scheme based on trait values as well as under population stratification.

The score test is derived from a mixed effects model where population level association is modeled using a fixed effect and where correlation among related individuals is allowed for by using log-gamma random effects.

We show that a random effects formulation of co-inheritance can improve the power substantially.

We apply the method to data from the Collaborative Study on the Genetics of Alcoholism. We compare our findings to previously published results.

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REPRINT REQUEST E-MAIL: gudrun.jonasdottir@ki.se
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Press Release: New A.A. Stories Speak Directly to Very Young Alcoholics




For Immediate Release


April 5, 2007 -

• “If I could have stayed cool, I’d still be drinking. Very quickly, though, I started getting into trouble. Going to sixth grade got in the way of my life, which consisted of getting drunk as much as possible.” [After rehab] “I was going to A.A. meetings. Everyone was older, even most of the kids at the young people meetings. But I found that alcoholics understand other alcoholics. . . . Regardless of how young or old or ‘special’ I am, in A.A. I’m just a drunk.” Tina, who joined A.A. at 13

• “I loved drinking and was as addicted to the lies, the shady people and places as I was to the alcohol. My grades suffered until I stopped going to school altogether. . . . I found myself in places without any idea of how I had gotten there. I overdosed on alcohol.” Since coming to A.A., “I have been given an opportunity to grow up with the Twelve Steps in my life. It is with utmost gratitude that I have just celebrated my 19th year of continuous sobriety.” Kevin, who joined A.A. at 14



NEW YORK CITY—Tina and Kevin are two of the 19 very young alcoholics who relate their experience as recovering alcoholics in a revised pamphlet just released by Alcoholics Anonymous: “Young People and A.A.” Eight recollections by early teen and preteen alcoholics are included in the new edition, which also contains most of the original stories by alcoholics 25 and under.

. . . . READ FULL PRESS RELEASE
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NEWS RELEASE: Drink driving – good progress in some countries, but others hold Europe back


17 April 2007, Brussels –

A new study published today under ETSC’s Road Safety Performance Index (PIN)(1) indicates that in Europe, improvements in drink driving contribute their share to enhancing road safety. However, in nine countries, insufficient progress on reducing drink driving deaths has slowed down overall improvement over the last decade.

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Road Safety Performance Index (PIN) Flash 5 Reducing death from drink driving
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Monday, April 16, 2007

Revolving Door for Addicts Adds to Medicaid Cost

Published: April 17, 2007

With grim humor, some doctors in New York call them “frequent fliers” — addicts who check into hospital detoxification units so often that dozens of them spend more than 100 nights a year in those wards.

Through its Medicaid program, New York spends far more than other states on drug and alcohol treatment, including more than $300 million a year paid to hospitals for more than 30,000 detox patients. One reason for the high cost is that $50 million is spent just on the 500 most expensive patients, at a cost of about $100,000 a person. These patients check in and out of detox wards, on average, more than a dozen times a year — a practice that experts say would not be tolerated in most states.

. . . . READ FULL ARTICLE

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One in Four Hospital Patients Is Admitted With a Mental Health or Substance Abuse Disorder
Press Release Date: April 10, 2007

Almost one-fourth of all stays in U.S. community hospitals for patients age 18 and older—7.6 million of nearly 32 million stays—involved depressive, bipolar, schizophrenia and other mental health disorders or substance use related disorders in 2004, according to a new report by HHS' Agency for Healthcare Research and Quality.

This study presents the first documentation of the full impact of mental health and substance abuse disorders on U.S. community hospitals. According to the report, about 1.9 million of the 7.6 million stays were for patients who were hospitalized primarily because of a mental health or substance abuse problem. In the other 5.7 million stays, patients were admitted for another condition but they also were diagnosed as having a mental health or substance abuse disorder.

Nearly two-thirds of costs were billed to the government: Medicare covered nearly half of the stays, and 18 percent were billed to Medicaid. Roughly 8 percent of the patients were uninsured. Private insurers were billed for the balance. The study also found that one of every three stays of uninsured patients was related to a mental health or substance abuse disorder.

"Community hospitals play an important role in the treatment of people with mental health and substance abuse disorders," said AHRQ Director Carolyn M. Clancy, M.D. "This report gives health care policymakers an in-depth look at the impact of mental health and substance abuse care on the health care system."

Substance Abuse and Mental Health Services Administration Administrator Terry Cline, Ph.D., said, "The significant number of hospital stays related to mental health and substance use disorders signals the need for an increased national effort to identify and intervene early before the conditions require a hospital stay. Too often because of social stigma or lack of understanding, individuals and health care providers don't recognize the signs or treat mental health or substance use disorders with the same urgency as other medical conditions."

AHRQ found that most patients with mental health and substance abuse disorders were older. For example, although people age 80 and older comprised only 5 percent of the U.S. population in 2004, they accounted for nearly 21 percent of all hospital stays for these conditions—principally for dementia. There were also gender differences. The most frequent admitting diagnosis for women was mood disorders, while that for men was substance abuse.

AHRQ also found that patients who have been diagnosed with both a mental health condition and a substance abuse disorder—those with "dual diagnoses"—accounted for 1 million of the nearly 8 million stays. Nearly half of these cases with dual diagnoses involved drug abuse, a third involved alcohol abuse, and one in five involved both drug and alcohol abuse.

In addition, 240,000 women hospitalized for childbirth or pregnancy also had mental health or substance abuse problems. Four of every 10 of these patients were between 18 and 24 years of age.

Suicide attempts accounted for nearly 179,000 hospital stays. Of these, 93 percent involved a mental health condition—most commonly mood disorders—and/or substance abuse. Nearly three-quarters of these patients were between ages 18 and 44 and more than half were women. Poisoning, by overdosing prescription medicines or ingesting a toxic substance was the most common way patients attempted suicide.

The report is based on 2004 data—the latest currently available—from AHRQ's Healthcare Cost and Utilization Project Nationwide Inpatient Sample, a database of hospital inpatient stays that is nationally representative of all short-term, non-federal hospitals. The data are drawn from hospitals that comprise 90 percent of all discharges in the United States and include all patients, regardless of insurance type, as well as the uninsured. For details, go to Care of Adults with Mental Health and Substance Abuse Disorders in U.S. Community Hospitals, 2004 at http://www.ahrq.gov/data/hcup/factbk10/.

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The concentration-dependent effects of ethanol on Caenorhabditis elegans behaviour

The Pharmacogenomics Journal
advance online publication 27 February 2007;





The effects of ethanol on the brain are concentration dependent. Low concentrations (mM) intoxicate, while greater than 100 mM anaesthetize.

Of most relevance to human alcohol addiction are mechanisms of intoxication. Previously, Caenorhabditis elegans has been employed in genetic screens to define effectors of intoxication.

Here, we inform interpretation of these studies by providing evidence that ethanol rapidly equilibriates across C. elegans cuticle.

Thus, modelling intoxication in C. elegans requires exposure to external ethanol less than 100 mM.

Furthermore, the permeability of the cuticle to ethanol enables analysis of precisely controlled concentration-dependent effects of acute, chronic, and episodic ethanol exposure on behaviour.

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REPRINT REQUEST E-MAIL: lmhd@soton.ac.uk
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Apolipoprotein E polymorphism, homocysteine serum levels and hippocampal volume in patients with alcoholism: an investigation of a gene–environment interaction

The Pharmacogenomics Journal advance online publication 10 April 2007;

There is growing evidence that disadvantageous influences of the apolipoprotein E4 allele in the central nervous system are modified by environmental and dietary conditions.

The present study investigated the gene–environment interaction of apolipoprotein E4 with homocysteine serum levels in patients with alcohol dependence with regard to alcohol-related hippocampal volume loss usng volumetric high-resolution magnetic resonance imaging.

The ApoE4 allele constitutes a risk factor for hippocampal volume loss in patients with alcohol dependence under the conditions of hyperhomocysteinemia. We suggest that the disadvantageous effects of apolipoprotein E4 on alcohol-related brain volume loss are based on certain gene–environment interactions.

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REPRINT REQUEST E-MAIL:
julia.wilhelm@uk-erlangen.de
PRESS RELEASE:
Men who habitually consume alcohol more likely to have a sleep-related breathing disorder

WESTCHESTER, Ill. -- Increased usual alcohol consumption among men is associated with an increased risk of a mild or worse sleep-related breathing disorder (SRBD), according to a study published in the April 15th issue of the Journal of Clinical Sleep Medicine (JCSM).

The study, authored by Paul E. Peppard, PhD, and colleagues at the University of Wisconsin-Madison, focused on 775 men and 645 women, who were evaluated for alcohol consumption and a sleep-related breathing disorder. It was discovered that, relative to men who consumed less alcohol, for each increment of one drink per day, men who consumed more alcohol had 25 percent greater odds of a mild or worse SRBD.

Among women, minimal to moderate alcohol consumption was not significantly associated with an increased risk of an SRBD. According to Peppard, possible explanations for this include the limited range of alcohol consumption reported by women in the study sample, reducing the ability to detect clinically important moderate associations. Alternatively, added Peppard, women may be more resistant than men to threats to nocturnal respiratory stability. Such protection may be due to hormonally-mediated increased ventilatory drive, anatomical differences or other characteristics that may provide general protection for women from events of an SRBD, noted Peppard, adding that women, for example, appear to require relatively greater increases in body mass to demonstrate weight-related increments in an SRBD compared to men.

“Experimental evidence is fairly consistent in demonstrating acute effects of alcohol exposure on initiating or exacerbating an SRBD, perhaps by reducing upper airway patency via reduced dilatory muscle tone, or by blunted ventilatory response to hypoxia,” said Peppard. “Based on the previous experimental evidence, men and women with an SRBD, or those particularly susceptible to an SRBD, should be advised to avoid alcohol near bedtime.”

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Association of Alcohol Consumption and Sleep Disordered Breathing In Men And Women
Journal of Clinical Sleep Medicine
Vol. 3 No. 2 pp. 265-270


Experimental evidence indicates that alcohol use near bedtime may exacerbate sleep disordered breathing (SDB).

In this population based epidemiology study, our objective is to measure the association of SDB with usual alcohol consumption habits.

In men, increased usual alcohol consumption was associated with increased risk of mild or worse SDB. Persons with SDB might benefit from generally reduced alcohol consumption and not just avoidance near bedtime.

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REPRINT REQUEST E-MAIL: ppeppard@wisc.edu
KNOWLEDGE AND ATTITUDES ABOUT PHARMACOTHERAPY FOR ALCOHOLISM: A SURVEY OF COUNSELORS AND ADMINISTRATORS IN COMMUNITY-BASED ADDICTION TREATMENT CENTRES
Alcohol and Alcoholism 2007 42(2):113-118;




Medications, when combined with psychosocial therapy, can improve treatment outcomes in alcoholics; however, medications are not widely utilized in community-based addiction treatment centres. Of interest is how non-medical addiction treatment professionals in these facilities view adjunctive pharmacotherapies for alcoholism.

The present report focuses on baseline data collected during the course of an educational intervention project and explores predictors of positive attitudes about adjunctive pharmacotherapies among community addiction counselors and administrators.

These data support that more widespread use of adjunctive pharmacotherapy for alcoholism may be impeded by the fact that addictions counselors, who are often the first contact for treatment-seeking individuals, have a lack of knowledge and a lack of confidence in the effectiveness of such treatments. Directed educational interventions are warranted for this population.

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REPRINT REQUEST E-MAIL: thomass@musc.edu

Sunday, April 15, 2007

BEER INSTITUTE NEWSLETTER






March 2007 PDF Download
  • Chairman's Column
  • Legal-Regulatory Update
  • Government Affairs
  • Save the Date
  • Brooklyn Brewery
  • New Member Profile
  • 2006 Per Capita Consumption Estimates
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The alcoholic lung: epidemiology, pathophysiology, and potential therapies
Am J Physiol Lung Cell Mol Physiol
292: L813-L823, 2007



Epidemiological evidence gathered only in the past decade reveals that alcohol abuse independently increases the risk of developing the acute respiratory distress syndrome by as much as three- to fourfold.

This review focuses on the epidemiology and the pathophysiology of alcohol-induced lung dysfunction and discusses potential new treatments suggested by recent experimental findings.

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REPRINT REQUEST E-MAIL: pcjoshi@emory.edu