
Policy responses to the growing burden of alcohol-related disease  fail to consider the interrelated nature of substance misuse and the  potential for complex interactions in response to alcohol-specific  interventions. 
This paper considers possible aggregate level  responses to the alcohol policy and whether alcohol policy can be  expected to reduce overall harm.
A review and  discussion of the relevant literature was conducted.
Evidence indicates that those at greatest risk consume stronger  alcoholic beverages more frequently, that they are likely to  complement their consumption with a range of intoxicants and that  they are more likely to substitute alcohol with other substances.
Policies aimed at reducing alcohol consumption can be successful. However, evidence suggests a significant minority of consumers are likely to substitute or complement consumption with a range of intoxicants suggesting that policy is unlikely to reduce all-cause mortality and morbidity. Further research into the nature of substitution and complementarity is required.