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Thursday, October 15, 2009

Adverse childhood events as risk factors for substance dependence: Partial mediation by mood and anxiety disorders
Addictive Behaviors Volume 35, Issue 1, January 2010, Pages 7-13

Adverse childhood events (ACEs) are associated with negative health outcomes. We examined ACEs as risk factors for substance dependence (SD) and the mediating effects of mood and anxiety disorders on the relations between ACEs and SD risk.

ACEs appear to contribute additively to the risk of SD, with mood and anxiety disorders in the causal path for a portion of this risk. The identification and effective treatment of mood and anxiety disorders associated with ACEs could reduce the risk of developing SD.


Request Reprint E-Mail: kranzler@psychiatry.uchc.edu

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