An international website dedicated to providing current information on news, reports, publications,and peer-reviewed research articles concerning alcoholism and alcohol-related problems throughout the world. Postings are provided by international contributors who monitor news, publications and research findings in their country, geographical region or program area of interest. All postings are entered without editorial or contributor opinion or comment.
Aims
For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.
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Thursday, August 23, 2012
A Role of Genomic Copy Number Variation in the Complex Behavioral Phenotype of Alcohol Dependence: A Commentary
Moderate drinking? Alcoholconsumption significantly decreasesneurogenesis in the adulthippocampus
Male and female adult Sprague-Dawley rats were provided free access to a liquid replacement diet that was supplemented with either 4% ethanol or Maltodextrin for a period of two weeks. Proliferating cells were labeled with 5-bromo-2-deoxyuridine (BrdU) and the number of BrdU-positive cells in the hippocampus was assessed after the final day of drinking. A subset of rats was also exposed to a motor skill or associative learning task to examine the functional effects of alcoholconsumption.
The drinking regime resulted in an average blood alcohol concentration of approximately 0.08%;which is comparable to the human legal driving limit in many countries. This level of intoxication did not impair motor skill learning or function in either sex;nor did the alcoholconsumption disrupt associative learning two days after drinking.
Therefore; moderate alcohol consumption did not disrupt basic sensory;motor or learning processes. However;the number of cells produced in the dentate gyrus of the hippocampus was reduced by nearly 40%.
Wednesday, August 22, 2012
Alcohol Consumption as a Barrier to Prior HIV Testing in a Population-Based Study in Rural Uganda
Alcohol use was not associated with prior HIV testing among men. HIV testing strategies may thus need to specifically target women who drink alcohol.
FASD News - 33/2012
Living in proximity of a bar and risky alcohol behaviours: A longitudinal study

We examined whether distance from home to the nearest bar, i.e. alcohol outlet permitting consumption on the premises, is associated with risky alcohol behaviours.Cross-sectional and longitudinal study.
The cross-sectional data consisted of 78 858 and the longitudinal data of 54 778 Finnish Public Sector Study participants in between 2000 and 2009 [mean follow-up 6.8 years (SD=2.0)].
Distances from home to the nearest bar were calculated using Global Positioning System-coordinates. The outcome variables were heavy alcohol use (drinking above the weekly guidelines) and extreme drinking occasions (passing out due to alcohol use). We used binomial logistic regression in cross-sectional analyses and in longitudinal mixed effects (between-individual) analyses. Conditional logistic regression was used in longitudinal fixed effects (within-individual) analyses.
Cross-sectionally, the likelihood of an extreme drinking occasion and heavy use was higher among those who resided <1 vs. ≥1 km from a bar. Longitudinally, between individuals, a decrease from >1 km to ≤1 km in distance was weakly associated with an extreme drin
king occasion (1.18, 95% CI 0.98–1.41), and heavy use (1.12, 95% CI 0.97–1.29). Within-individual, the odds ratio for becoming a heavy user was 1.17 (95% CI, 1.02–1.34), per 1 km decrease in log-transformed continuous distance, the corresponding odds ratio for an extreme drinking occasion was 1.03 (95% CI, 0.89–1.18).
Moving place of residence close to or far from a bar appears to be associated with a small corresponding increase or decrease in risky alcohol behaviour.
News Release - First evidence from humans on how alcohol may boost risk of cancer
Almost 30 years after discovery of a link between alcohol consumption and certain forms of cancer, scientists are reporting the first evidence from research on people explaining how the popular beverage may be carcinogenic. The results, which have special implications for hundreds of millions of people of Asian descent, were reported here today at the 244th National Meeting & Exposition of the American Chemical Society.
Silvia Balbo, Ph.D., who led the study, explained that the human body breaks down, or metabolizes, the alcohol in beer,
The 5-item Alcohol Use Disorders Identification Test (AUDIT-5): An Effective Brief Screening Test for Problem Drinking, Alcohol Use Disorders and Alco
To identify an optimal brief version of the Alcohol Use Disorders Identification Test (AUDIT) and to evaluate its effectiveness as a screening test for problem drinking (PD), alcohol use disorders (AUD) and alcohol dependence (AD).
Widening Access to Treatment for Alcohol Misuse: Description and Formative Evaluation of an Innovative Web-Based Service in One Primary Care Trust
Alcohol, tobacco and drug use as reasons for abortion
Relationship Between Price Paid for Off-Trade Alcohol, Alcohol Consumption and Income in England: A Cross-Sectional Survey
Maternal Alcohol Use during Pregnancy, Birth Weight and Early Behavioral Outcomes
Data on children born to women taking part in the United States National Longitudinal Survey of Youth (NLSY) (n = 1618) were analyzed using the sibling fixed-effects model, which helps adjust for maternal, genetic and social confounders when examining effects of pre-natal exposure to possible toxins such as alcohol. Mothers were classified as non-drinkers, light-to-moderate drinkers and heavy drinkers according to their frequency of alcohol use during pregnancy. Infants' behavioral outcomes were assessed using the modified Rothbart Infant Behavior Questionnaire in the NLSY, which measures three dimensions of behavioral outcomes: positive mood, fearfulness and difficultness.
Inequalities in the Distribution of the Costs of Alcohol Misuse in Scotland: A Cost of Illness Study
Request Reprint E-Mail: marjorie.johnston@nhs.net
Sleep Problems in Children with Fetal Alcohol Spectrum Disorders
Sleep problems in children with fetal alcohol spectrum disorders (FASD) are reportedly common but not well characterized. Objectives were to: (1) assess sleep concerns in children with FASD using a caregiver-report survey, the Children's Sleep Habits Questionnaire (CSHQ); (2) compare CSHQ results with those of previously reported community sample; and (3) describe pilot polysomnography findings in children with FASD.
Children with FASD were recruited from a behavioral intervention study, and participating caregivers completed the CSHQ. CSHQ results were compared with the original data from a previously published community sample of similar age. Participants with FASD and elevated CSHQ scores were offered overnight polysomnography.
Thirty-three children with FASD (4.1-12.1 years) were enrolled; 85% of children with FASD scored above the clinical cutoff Total Score of 41, reflecting marked sleep disturbance. Elevated subdomain scores occurred primarily in areas concerning for pediatric insomnia. Those with comorbid ADHD had elevated CSHQ on additional subdomains with no difference in Total Scores. Compared with the community sample, children with FASD had higher Total Scores on the CSHQ (52 vs. 39, p < 0.001). Polysomnography, completed in 5 subjects, revealed mild sleep disordered breathing and fragmented sleep with elevated non-respiratory arousal indices.
Clinically significant sleep problems are present in children with FASD on both subjective and objective measures. Further investigation is needed to better describe these sleep disturbances and their impact on overall health and daytime neurobehavioral problems in this clinical population.
Tuesday, August 21, 2012
JRF report: 'A positive choice: Young people who drink little or no alcohol'
A new report into the influences on non or light drinking young people in the UK has been released by the Joseph Rowntree Foundation.
Download the full report 'A positive choice: Young people who drink little or no alcohol' or summary here.
The study examined the lives and choices of young people (aged 16-25) who drink little or no alcohol. It explores the influences that shape their decisions and how their choices and patterns of consumption affect their lives. > > > > Read More
Predicting persistent alcohol problems: a prospective analysis from the Great Smoky Mountain Study
Rates of alcohol disorders peak in late adolescence and decrease substantially into the mid-20s. Our aim was to identify risk factors that predict alcohol problems that persist into the mid-20s.
Data are from the prospective, population-based Great Smoky Mountains Study (GSMS; n=1420), which followed children through late adolescence and into young adulthood. Alcohol persisters were defined as subjects with an alcohol disorder (abuse or dependence) in late adolescence (ages 19 and 21 years) that continued to meet criteria for an alcohol disorder at the mid-20s assessment.
The 3-month prevalence of having an alcohol disorder (abuse or dependence) decreased markedly from late adolescence into the mid-20s. A third of late adolescents with an alcohol disorder continued to meet criteria for an alcohol disorder in young adulthood (37 of 144 who met criteria in late adolescence). Risk factors for persister status included multiple alcohol abuse criteria during late adolescence but no alcohol dependence criteria. Risk factors for persister status also included associated features of alcohol dependence such as craving alcohol and drinking to unconsciousness. Persister status was also associated with depression, cannabis dependence and illicit substance use, but not with other psychiatric disorders. More than 90% of late adolescents with three or more of the risk factors identified met criteria for a young adult alcohol disorder.
Symptoms of alcohol abuse, not dependence, best predict long-term persistence of alcohol problems. The set of risk factors identified may be a useful screen for selective and indicated prevention efforts.
Request Reprint E-Mail: William.Copeland@duke.edu
International Recovery Coaching Conference - London
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What Is Recovery?

Monday, August 20, 2012
Alcohol News - 34/2012
Study examines the relationship between marriage and alcohol
Based on survey data and interviews, the authors revealed that married men reported consuming the lowest number of drinks, compared with single, divorced, and widowed men. That's in part because of their wives' lower levels of drinking, write the authors. Men also were more likely than women to turn to drinking after a divorce.
On the other hand, the researchers found that married women consumed more drinks than long-term divorced or recently widowed women, in part because they lived with men who had higher levels of alcohol use.
The authors of the study are Corinne Reczek, an assistant professor of sociology at the University of Cincinnati; Tetyana Pudrovska, an assistant professor of sociology and demography at The Pennsylvania State University; Deborah Carr, a professor of sociology at Rutgers University; and Debra Umberson, a professor of sociology at University of Texas at Austin.
The researchers analyzed survey data from the Wisconsin Longitudinal Study to explore population trends in the relationship between marriage and alcohol. They also analyzed data from two in-depth interview studies, the Marital Quality Over the Life Course Project, conducted between 2003-2006, and the Relationships and Health Habits Over the Life Course Study, conducted between 2007-2010.
The researchers also found that:
- In each marital status category, men consumed a greater average number of drinks than women.
- Across every marital status category, a higher proportion of men than women also reported having at least one drinking-related problem.
- Recently divorced men reported consuming a significantly greater average number of drinks than men in long-term marriages.
- Reporting at least one drinking-related problem was significantly higher among long-term divorced and recently divorced women than long-term married women.
The researchers gauged alcohol consumption by total number of drinks consumed in a month.
The researchers suggest that future research should examine more closely how widowhood shapes alcohol use over time, as well as explore alcohol differences across race-ethnicity. > > > > Read More