Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Thursday, January 14, 2010

The Intensity of Binge Alcohol Consumption Among U.S. Adults


Binge drinking (consuming five or more drinks during a drinking occasion) is responsible for more than half of the 79,000 annual deaths due to excessive drinking in the U.S. Although studies show a strong dose–response relationship between the intensity of binge drinking (i.e., the number of drinks consumed per binge episode) and adverse outcomes, there are no population-based studies assessing this measure,

Binge drinkers consumed an average of 8.0 drinks (median 6) during their most recent binge drinking episode; 70.0% of binge drinkers consumed six or more drinks, and 38.4% consumed eight or more drinks. Men consumed more drinks during their last binge episode than women (M=8.3 vs 7.0, median=7 vs 6), and those aged 18–34 years consumed more drinks than those aged >34 years for both men and women. Independent risk factors for consuming eight or more drinks included being male; being aged <35>

Most adult binge drinkers drink in excess of the five-drink threshold defining this risky behavior. The intensity of binge drinking should be monitored regularly by health agencies to improve surveillance and to better assess the impact of interventions designed to reduce binge drinking and its consequences.

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Request Reprint E-Mail tbn7@cdc.gov

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Excerpts from Transcript of Meeting on Measures to Reduce Alcohol Consumption in Russia


PRESIDENT OF RUSSIA DMITRY MEDVEDEV: Colleagues,

As was agreed a while ago, we are meeting today in expanded format to discuss measures for fighting alcoholism. At the State Council meeting on youth policy we agreed to address this subject separately, in detail, and make the necessary decisions.

You know just how serious a problem alcoholism has become for our country. Frankly speaking, it has taken on the proportions of a national disaster. According to the Healthcare and Social Development Ministry’s statistics, per capita alcohol consumption in Russia – taking the whole population, including babies – now stands at 18 litres of pure alcohol a year. You can calculate for yourselves how many bottles of vodka this means – quite simply alarming. This is more than twice the level that the World Health Organisation defines as dangerous for people’s health and lives. Such a high level is quite simply a real threat to our country’s and people’s normal life.

We have taken various measures over these last years of course. Tighter rules on production and sale of alcoholic beverages were introduced, and significant restrictions were imposed on their advertising. Tougher penalties were introduced for drunk driving. But so far, we have not seen any real change in the situation. To be really honest, all of these efforts have had no real effect at all. Let’s be up front about this. All they have done is brought some order to the situation. . . . . .

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Substance Use Disorders and Risk for Completed Suicide


Substance use disorders are among the most frequent psychiatric disorders found in suicides. In psychological autopsy studies between 19% and 63% of all suicides suffered from substance use disorders, mostly from alcohol use disorders.

Suicide risk is highly increased in substance use disorders, particularly in alcohol use disorders, and in co-morbid alcoholism and depression. So far, some risk factors for suicide have been identified in alcoholism. Nevertheless, various questions about the relationship between substance use disorders and suicide remain open, which indicate directions for future research.

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Tuesday, January 12, 2010

SCIENCE AND INDUSTRY: COMMENTS ON THE COMMENTARIES


We appreciate the thoughtful, diverse and engaging comments on our paper [1] by these distinguished alcohol academicians. We are even more grateful for the opportunity to respond.

First, we agree with Professor Heath's comments [2] that alcohol is known to have social as well as medical benefits, and that we could learn much by studying its benefits. However, given the increasing involvement of industry in alcohol science, studies of positive effects of drinking would be more trustworthy if they are not funded by the industry. We absolutely agree with Tanya Chikritzhs [3] and others that addiction journals have a crucial role to play as gatekeepers and that there is need for more research on conflict of interest declarations, as well as on all kinds of bias in alcohol research. . . . . .

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THE GOOD, THE BAD AND THE UGLY


Stenius & Babor [1] believe that there are three types of researchers: the good ones, who puristically almost wholly avoid any communication with the beverage alcohol industry; the bad ones, who naively and simple-mindedly see potential partnerships with the industry as acceptable; and the ugly ones, who think that collaboration with the industry (under strong regimentation) might be possible. Those who cannot be wholly good are threatened ('well advised') about damaging their futures (loss of reputation in a world going towards stringent 'ethical' standards). . . . . .

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WANTED: A BROADER VIEW OF ALCOHOL STUDIES


Rather than address in detail the specific findings and recommendations of this paper, I would like to voice my reservations about a simple premise upon which it is based.

It seems unfortunate that, in the opening paragraph, the authors include in 'the alcohol research community . . . [only] . . . individuals and organizations responsible for the production and interpretation of scientific information about the nature, causes and control of alcohol-related problems' ([1]. p. 191; emphasis added).

There is no doubt that 'heavy' or 'excessive' drinking of beverages containing alcohol is associated clearly with a broad range of social, psychological and biomedical problems. However, especially during the last decade, we have also seen a host of studies using various methods, based on large samples, over long periods of time, from around the world, with statistically significant evidence that 'light' or 'moderate' drinking is associated with a broad range of social, psychological and biomedical benefits or advantages. It hardly seems fair that the distinguished scientists who conduct such studies should be excluded from the 'alcohol research community' after having devoted years contributing to our understanding of ethanol and its relation to human beings. A brief summary of how this selective view came to be accepted widely is to be found in the paper by Heath [2]. . . . . .

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RESEARCH FUNDING—A COMPLEX BUSINESS


Having served as a scientist in the Finnish Alcohol Monopoly for 15 years, after receiving individual tax-free grants from the same source for several years, I feel perplexed to read the recommendation that '. . . it should be recognized from the information reviewed in this paper that under most circumstances collaboration [of researchers] with the alcoholic beverage industry is neither warranted nor advisable'. The Finnish monopoly, which capped not only retail but also wholesale, importation and production (of a wide range of goods) in its orb, had other constraints besides grinding money to the state; but it, too, had interests, not least of them getting rid of us. For the businessmen we were simply useless. Our research rarely troubled them enough to incite any attempts to interfere, even when we proposed and in fact convinced the alcohol policy circle for a short while that limiting the growth of the overall consumption, i.e. the business of our funding source, is a good idea [1].

Stenius & Babor have provided an important service to the research community by mapping out systematically the risks and hazards involved in receiving funding from private sources and in listing altogether 24 recommendations to all participants as how to avoid them [2]. Nevertheless, their perspective is very Nordic. If the alcohol industries were not to fund any research there would be practically none in France, Italy and probably many other countries. The original source of international alcohol consumption statistics was the Dutch distilling industry. Even in countries where alcohol research is funded formally from governments, the money is often raised from the drinks business. Their advice would stop most of the gambling research in the whole world. Applied to research on dangerous consumption or otherwise controversial social issues, the conclusion becomes even more confusing: think of the Volkswagen foundation, the Wellcome Foundation, the Guggenheim Foundation, the Rockefeller Foundation and thousands of other sources that fund research not only on alcohol and drug policy relevant topics, but also on other issues that involve conflicting interests. If anyone who makes money on a product would not be allowed to use it for research [3], the profits might be smaller but also many people would be less well and die earlier. . . . .

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PROTECTING THE INTEGRITY OF SHARED SCIENTIFIC KNOWLEDGE: IS THE CONFLICT OF INTEREST STATEMENT ENOUGH?


Stenius & Babor offer an erudite approach to the divisive problem of alcohol beverage industry research funding. They urge scientists strongly to abstain but recognize that not all will be able or willing [1].

Earlier this year, an extraordinary expression of support emerged for the 'hands-off' approach [2]. More than 50, mainly Australian, scientists (this author included) and health experts co-signed a letter to the editor of the Medical Journal of Australia highlighting the pro-industry function of social aspects/public relations organizations (SAPROs) [3] and pledging to reject funding from the Australian alcohol SAPRO, 'DrinkWise'[2]. A relative newcomer, DrinkWise has reportedly funded research by 'leading academics'[sic] from at least five Australian universities [4]. . . . .

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CONFLICTS OF INTEREST. A GOLDEN STANDARD TO GENERALIZE IN ADDICTION RESEARCH


It is difficult to disagree with Stenius & Babor [1]. The points they make are clear, consistent, logical and full of common sense. Also, anyone who has been in the field long enough to have some white hairs on his head (and I have plenty of those) has at some time experienced situations such as those described by the authors. As well, evidence on the hidden strategies of the alcohol industry against public health advocates continues to grow [2]. . . . .

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The dimensionality of alcohol use disorders and alcohol consumption in a cross-national perspective


To replicate the finding that there is a single dimension trait in alcohol use disorders and to test whether the usual 5+ drinks for men and 4+ drinks for women and other measures of alcohol consumption help to improve alcohol use disorder criteria in a series of diverse patients from emergency departments (EDs) in four countries.

Using exploratory factor analyses alcohol use disorders can be described as a single, unidimensional continuum without any clear-cut distinction between the criteria for dependence and abuse in all sites. Results from item response theory analyses showed that the current DSM-IV criteria tap people in the middle–upper end of the alcohol use disorder continuum. Alcohol consumption (amount and frequency of use) can be used in all EDs with the current DSM-IV diagnostic criteria to help tap the middle–lower part of this continuum. Even though some specific diagnostic criteria and some alcohol consumption variables showed differential item function across sites, test response curves were invariant for ED sites and their inclusion would not impact the final (total) performance of the diagnostic system.

DSM-IV abuse and dependence form a unidimensional continuum in ED patients regardless of country of survey. Alcohol consumption variables, if added, would help to tap patients with more moderate severity. The DSM diagnostic system for alcohol use disorders showed invariance and performed extremely well in these samples.

Read Full Abstract

Request Reprint E-Mail: guibor@imp.edu.mx

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Alcohol Screening: Resources


CDC has developed Screening and Brief Intervention (SBI) for Unhealthy Alcohol Use: A Step-By-Step Implementation Guide for Trauma Centers to help Level I and II trauma centers plan, implement, and continually improve the new Committee on Trauma (COT) alcohol-screening and brief intervention requirements.

The guide includes steps and resources:

  • Developing an SBI plan
  • Choosing the team, including those providing the intervention
  • Gaining long-term “buy-in”
  • Implementing and Refining the SBI plan
  • Worksheets to plan and track results
  • Online resources
  • Research articles on SBI
Download Screening and Brief Intervention (SBI) for Unhealthy Alcohol Use: A Step-by Step Implementation Guide for Trauma Centers
(PDF)

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Monday, January 11, 2010

Alcohol-Induced Blackout


For a long time, alcohol was thought to exert a general depressant effect on the central nervous system (CNS). However, currently the consensus is that specific regions of the brain are selectively vulnerable to the acute effects of alcohol.

An alcohol-induced blackout is the classic example; the subject is temporarily unable to form new long-term memories while relatively maintaining other skills such as talking or even driving.

A recent study showed that alcohol can cause retrograde memory impairment, that is, blackouts due to retrieval impairments as well as those due to deficits in encoding. Alcoholic blackouts may be complete (en bloc) or partial (fragmentary) depending on severity of memory impairment. In fragmentary blackouts, cueing often aids recall. Memory impairment during acute intoxication involves dysfunction of episodic memory, a type of memory encoded with spatial and social context.

Recent studies have shown that there are multiple memory systems supported by discrete brain regions, and the acute effects of alcohol on learning and memory may result from alteration of the hippocampus and related structures on a cellular level.

A rapid increase in blood alcohol concentration (BAC) is most consistently associated with the likelihood of a blackout. However, not all subjects experience blackouts, implying that genetic factors play a role in determining CNS vulnerability to the effects of alcohol. This factor may predispose an individual to alcoholism, as altered memory function during intoxication may affect an individual‟s alcohol expectancy; one may perceive positive aspects of intoxication while unintentionally ignoring the negative aspects.

Extensive research on memory and learning as well as findings related to the acute effects of alcohol on the brain may elucidate the mechanisms and impact associated with the alcohol- induced blackout.


Read Full Article (PDF)
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The myths of boozed-up Britain


Saloon bar oracles sit with their half-empty glasses and put the world to rights. The British pub has long hosted the debates which answer every question: what to do about yobs, immigrants, bankers, queues, TV repeats, noisy neighbours and the weather? On one subject, the drinker counts himself particularly expert, of course - booze.

So, if the conversation at your local tonight comes round to the latest ideas on what we should do about the problems of alcohol, I have culled a few key points from the parliamentary report on the subject published today. . . . . .

Read Full Article

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Sunday, January 10, 2010

Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant


In approximately one billion people, a point mutation inactivates a key detoxifying enzyme, aldehyde dehydrogenase (ALDH2).

This mitochondrial enzyme metabolizes toxic biogenic and environmental aldehydes, including the endogenously produced 4-hydroxynonenal (4HNE) and the environmental pollutant acrolein, and also bioactivates nitroglycerin.

ALDH2 is best known, however, for its role in ethanol metabolism. The accumulation of acetaldehyde following the consumption of even a single alcoholic beverage leads to the Asian alcohol-induced flushing syndrome in
ALDH2*2 homozygotes. The ALDH2*2 allele is semidominant, and heterozygotic individuals show a similar but less severe phenotype.

We recently identified a small molecule, Alda-1, that activates wild-type ALDH2 and restores near-wild-type activity to ALDH2
*2.

The structures of Alda-1 bound to ALDH2 and ALDH2
*2 reveal how Alda-1 activates the wild-type enzyme and how it restores the activity of ALDH2*2 by acting as a structural chaperone.

Read Full Abstract

Request Reprint E-Mail:
thurley@iupui.edu.
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Saturday, January 9, 2010

Alcohol reverses depressive and pronociceptive effects of chronic stress in mice with enhanced activity of the opioid system


The role of the opioid system in mediating effects of alcoholism and stress in depression is far from clear.

We studied, therefore, the effects of chronic mild stress (CMS) and alcohol drinking on depression-like behavior and nociception in lines of mice selected for high (HA) or low (LA) swim stress-induced analgesia.

Compared to the LA mice, the HA animals display up-regulation of opioid receptor system function and depression-like behavior in tail suspension test (TST).

We report now that alcohol reverses depressive and pronociceptive effect of CMS in HA mice. In contrast, in LA mice CMS does not affect nociception or behavior in TST and the animals are not susceptible to alcohol under CMS.

The results suggest that opioid system activity may determine the effects of alcohol on behavior under stress and, therefore, link predispositions to depression and to alcoholism.

Read Full Article (PDF)

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Alcohol Consumption, Serum Gamma-Glutamyltransferase, and Helicobacter Pylori Infection in a Population-Based Study Among 9733 Older Adults


Moderate alcohol consumption has been suggested to facilitate the elimination of Helicobacter pylori infection as the result of its antibacterial effect.

We aimed to assess the associations of current and lifetime alcohol consumption as well as serum gamma-glutamyltransferase (GGT), an established biomarker of alcohol consumption, with
H. pylori infection in a large population-based study.

A significant inverse association, in dose-response manner, was observed between both current and lifetime alcohol consumption and H. pylori seropositivity. The estimates based on lifetime consumption were more pronounced than the results for current consumption, and such inverse associations were found both for men and women. Stronger relations were observed for those who only drank wine or mixed drinkers compare with those who only drank beer. Furthermore, there was a significant inverse dose-response relationship between serum GGT levels and H. pylori seropositivity, which was selectively observed among alcohol drinkers.

In conclusion, our results support the hypothesis that moderate alcohol consumption may facilitate elimination of H. pylori.

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Request Reprint E-Mail: gaolei615@sohu.com

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NIAAA Official Says Alcoholism 'Isn't Usually' a 'Chronic, Relapsing Disease'


The Los Angeles Times notices that people can overcome drinking problems without abstaining from alcohol for the rest of their lives. More important, the Times quotes Mark Willenbring, director of treatment and recovery research at the National Institute on Alcohol Abuse and Alcoholism, who admits that the one-size-fits-all, abstinence-only approach preached by Alcoholics Anonymous is inconsisent with the evidence on drinking patterns (emphasis added): . . . . .

Read More
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Friday, January 8, 2010

Nick Heather on the 'controlled drinking controversy' and the origins of his interest in alcohol


Nick references David Davies, the Sobells and Australian work on controlled drinking treatment. Nick talks about how his interest in this topic was sparked, the book he wrote with Ian Robertson on this topic and the early trial of controlled drinking treatment they carried out.

View Video

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Nick Heather on Harm Reduction where it 'properly applies'


Nick talks about the work of Mansell Pattison in the 1970s of ‘attenuated drinking’ and makes other points about the goals of controlled drinking and moderation. “It’s when you extend that principle (of harm reduction) to everybody, I think, that you get the problems.”

View Video
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The More Things Change: Examining Alcohol Industry Issues Management Strategies


Every industry carefully plans how to advance its business agenda and counter threats to profitability. What makes industries change the strategies they use to respond to public pressure to modify health damaging practices? Do announced changes in practice reflect real change or are they simply old wine in new bottles?

In this report,
Corporations and Health Watch analyzes changes in alcohol industry responses to criticisms of its marketing practices.

Read Full Article
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Drink: The British Disease?


Britain has had a long and sometimes problematic relationship with alcohol. James Nicholls looks back over five centuries to examine the many, often unsuccessful, attempts to reform the nation’s drinking habits.

Read Full Article
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Estrogen Receptor Alpha as a Key Target of Red Wine Polyphenols Action on the Endothelium


A greater reduction in cardiovascular risk and vascular protection associated with diet rich in polyphenols are generally accepted; however, the molecular targets for polyphenols effects remain unknown. Meanwhile evidences in the literature have enlightened, not only structural similarities between estrogens and polyphenols known as phytoestrogens, but also in their vascular effects. We hypothesized that alpha isoform of estrogen receptor (ERα) could be involved in the transduction of the vascular benefits of polyphenols.

This study provides evidence that red wine polyphenols, especially delphinidin, exert their endothelial benefits via ERα activation. It is a major breakthrough bringing new insights of the potential therapeutic of polyphenols against cardiovascular pathologies.

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Health Committee - First Report Alcohol

Summary

Over the last 60 years English drinking habits have been transformed. In 1947 the nation consumed approximately three and a half litres of pure alcohol per head; the current figure is nine and a half litres. According to the General Household Survey data from 2006, 31% of men are drinking hazardously (more than 21 units per week) or harmfully (more than 50 units) of whom 9% are drinking harmfully. 21% of women are drinking hazardously or harmfully of whom 6% are drinking harmfully. While the consumption of alcohol has increased, taxation on spirits has declined in real terms and even more so as a fraction of average earnings.

The rising levels of alcohol consumption and their consequences have been an increasing source of concern in recent years. These involve not only the consequences of binge drinking which are a cause of many serious accidents, disorder, violence and crime, but also long term heavy drinking which causes more harm to health. The President of the Royal College of Physicians told us that alcohol was probably a significant factor in 30 to 40,000 deaths per year. The WHO has put alcohol as the third most frequent cause of death after hypertension and tobacco. UK deaths from liver cirrhosis increased more than five fold between 1970 and 2006; in contrast in France, Italy and Spain the number of deaths shrank between two and four fold; this country's deaths from cirrhosis are now above all of them.. In 2003 the P M's Strategy Unit estimated the total cost of alcohol to society to be £20 bn; another study in 2007 put the figure at 55 bn.

Faced by a mounting problem, the response of successive Governments has ranged from the non-existent to the ineffectual. In 2004 an Alcohol Strategy was published following an excellent study of the costs of alcohol by the Strategy Unit. Unfortunately, the Strategy failed to take account of the evidence which had been gathered.

The evidence showed that a rise in the price of alcohol was the most effective way of reducing consumption just as its increasing affordability since the 1960s had been the major cause of the rise in consumption. We note that minimum pricing is supported by many prominent health experts, economists and ACPO. We recommend that the Government introduce minimum pricing.

There is a myth widely propagated by parts of the drinks industry and politicians that a rise in prices would unfairly affect the majority of moderate drinkers. But precisely because they are moderate drinkers a minimum price of for example 40p per unit would have little effect. It would cost a moderate drinker 11p per week; a woman drinking the recommended maximum of 15 units could buy her weekly total of alcohol for £6.

Opponents also claim that heavier drinkers are insensitive to price changes, but as a group their consumption will be most affected by price rises since they drink so much of the alcohol purchased in the country. Minimum pricing would most affect those who drink cheap alcohol, in particular young binge-drinkers and heavy low income drinkers who suffer most from liver disease. It is estimated that a minimum price of 50p per unit would save over 3,000 lives per year, a minimum price of 40p, 1,100 lives.

Minimum pricing would have other benefits. Unlike rises in duty minimum pricing would benefit traditional pubs which sell alcohol at more than 40p or 50p per unit; unsurprisingly it is supported by CAMRA. Minimum pricing would also encourage a switch to weaker wines and beers. With a minimum price of 40p per unit, a 10% abv wine would cost a minimum of £2.80p, a 13% abv. wine £3.60p.

However, without an increase in duty minimum pricing would lead to an increase in the profits of supermarkets and the drinks industry. Alcohol duty should continue to rise year on year, but unlike in recent years duty increases should predominantly be on stronger alcoholic drinks, notably on spirits. The duty on spirits was 60% of male average manual weekly earnings in 1947; in 1973 (when VAT was imposed in addition to duty) duty was 16% of earnings; by in 1983 it was 11% and by 2002 it had fallen to 5%. We recommend that the duty on spirits be returned in stages to the same percentage of average earnings as in the 1980s. The duty on industrial white cider should also be increased. Beer under 2.8% can be taxed at a different rate and we recommend that the duty on this category of beer be reduced.

An increase in prices must be part of a wider policy aimed at changing our attitude to alcohol. The policy must be aimed at the millions who are damaging their heath by harmful drinking, but it is also time to recognise that problem drinkers reflect society's attitude to alcohol. There is a good deal of evidence to show that the number of heavy drinkers in a society is directly related to average consumption. Living in a culture which encourages drinking leads more people to drink to excess. Changing this culture will require a raft of policies.

Education, information campaigns and labelling will not directly change behaviour, but they can change attitudes and make more potent policies more acceptable. Moreover, people have a right to know the risks they are running. Unfortunately, these campaigns are poorly funded and ineffective at conveying key messages; people need to know the health risks they are running, the number of units in the drink they are buying and the recommended weekly limits, including the desirability of having two days drink-free each week. The information should be provided on the labels of alcohol containers and we recommend that all alcohol drinks containers should have labels containing this information. We doubt whether a voluntary agreement, even if it is possible to come to one, would be adequate. The Government should introduce a mandatory labelling scheme.

Expenditure on marketing by the drinks industry was estimated to be c. £600-800m in 2003. The current system of controls on alcohol advertising and promotion is failing the young people it is intended to protect. Both the procedures and the scope need to be strengthened. The regulation of alcohol promotion should be completely independent of the alcohol and advertising industries; this would match best practice in other fields such as financial services and professional conduct. In addition, young people should themselves be formally involved in the process of regulation: the best people to judge what a particular communication is saying are those in the target audience.

The current controls do not adequately cover sponsorship or new media which are becoming increasingly important in alcohol promotion. The codes must be extended to address better sponsorship. New media presents particular regulatory challenges, including the inadequacy of age controls and the problems presented by user generated content. Expert guidance should be sought on how to improve the protection offered to young people in this area. Finally, there is a pressing need to restrict alcohol advertising and promotion in places where children are likely to be affected by it.

Alcohol-related crime and anti-social behaviour have increased over the last 20 years, partly as a result of the development of the night time economy with large concentrations of vertical drinking pubs in town centres. The DCMS has shown extraordinary naivety in believing the Licensing Act 2003 would bring about 'civilised cafe culture'. In addition, the Act has failed to enable the local population to exercise adequate control of a licensing and enforcement regime which has been too feeble to deal with the problems it has faced. Some improvements have been made through the Policing and Crime Act 2009, in particular the introduction of mandatory conditions on the sale of alcohol. We urge the Government to implement them as a matter of urgency, but problems remain. It is of concern that section 141 of the Licensing Act 2003is not enforced and we call on the police to enforce it.

The 2009 Act has made it easier to review licences, giving local authorities the right to instigate a review. We support this. However, we are concerned that local people will continue to have too little control over the granting of licences and it will remain too difficult to revoke the licences of premises associated with heavy drinking. The Government should examine why the licences of such premises are not more regularly revoked.

In Scotland legislation gives licensing authorities the objective of promoting public health. Unfortunately, public health has not been a priority for DCMS. We recommend that the Government closely monitor the operation of the Scottish licensing act with a view to amending the Licensing Act 2003 to include a public health objective.

The most effective way to deal with alcohol related ill-health will be to reduce overall consumption, but existing patients deserve good treatment and a service as good as that delivered to users of illegal drugs, with similar levels of access and waiting times. As alcohol consumption and alcohol related ill health have increased, the services needed to deal which these problems have not increased; indeed, in many cases they have decreased, partly as a result of the shift in resources to dependency on illegal drugs.

Early detection and intervention is both effective and cost effective, and could be easily be built into existing healthcare screening initiatives and incentives for doing this should be provided in the QOF. However the dire state of alcohol treatment services is a significant disincentive for primary care services to detect alcohol related issues at an early stage before the serious and expensive health consequences of regular heavy drinking have developed. These services must be improved.

The alcohol problem in this country reflects a failure of will and competence on the part of government Departments and quangos. In the past Governments have had a large influence on alcohol consumption, be it from the liberalisation which encouraged the eighteenth century 'Gin Craze' to the restrictions on licensing in the First World War. Alcohol is no ordinary commodity and its regulation is an ancient function of Government.

It is time the Government listened more to the CMO and the President of the RCP and less to the drinks and retail industry. If everyone drank responsibly the alcohol industry might lose about 40% of its sales and some estimates are higher. In formulating its alcohol strategy, the Government must be more sceptical about the industry's claims that it is in favour of responsible drinking.

Read Full Contents

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Thursday, January 7, 2010

Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis


Alcoholism is characterized by successive periods of abstinence and relapse, resulting from long-lasting changes in various circuits of the central nervous system.

Accumulating evidence points to the endocannabinoid system as one of the most relevant biochemical systems mediating alcohol addiction. The endocannabinoid system regulates adult neurogenesis, a form of long-lasting adult plasticity that occurs in a few areas of the brain, including the dentate gyrus. Because exposure to psychotropic drugs regulates adult neurogenesis, it is possible that neurogenesis might be implicated in the pathophysiology, and hence treatment, of neurobiological illnesses related to drugs of abuse.

Here, we investigated the sensitivity of adult hippocampal neurogenesis to alcohol and the cannabinoid receptor agonist WIN 55,212-2 (WIN). Specifically, we analysed the potential link between alcohol relapse, cannabinoid receptor activation, and adult neurogenesis.

Adult rats were exposed to subchronic alcohol binge intoxication and received the cannabinoid receptor agonist WIN. Another group of rats were subjected to an alcohol operant self-administration task. Half of these latter animals had continuous access to alcohol, while the other half were subjected to alcohol deprivation, with or without WIN administration.

WIN treatment, when administered during alcohol deprivation, resulted in the greatest increase in alcohol consumption during relapse. Together, forced alcohol binge intoxication and WIN administration dramatically reduced hippocampal neurogenesis. Furthermore, adult neurogenesis inversely correlated with voluntary consumption of alcohol.

These findings suggest that adult hippocampal neurogenesis is a key factor involved in drug abuse and that it may provide a new strategy for the treatment of alcohol addiction and dependence.

Read Full Abstract

Request Reprint E-Mail:
pmlledo@pasteur.fr
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Alcohol and food: making the public health connections


UK policy must address the links between alcohol and food in order to maximise the effectiveness of public health responses and enable people to make better informed choices about eating and drinking.

We
urgently need to move away from seeing alcohol as a means to achieve inebriation to regarding itas an accompaniment to food with both being consumed in moderation.

Read Full Report (PDF)
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Portman Group


The following extract gives some insight into the context in which the Portman Group was established.

"In 1989, a new public relations alliance was formed by the UK's leading alcohol companies. Instrumental in setting the ball rolling was (Lord) John Wakeham, a Tory peer and then chairman of the Ministerial Group on Alcohol Issues. According to Anthony Hurse, civil servant at the Department of Health: "Lord Wakeham made it clear to the alcohol industry that he would like the industry's collaboration. He spoke to Peter Mitchell Director of Strategic Affairs at Guinness who agreed he'd do what he could. As a consequence of Wakeham's suggestions, the UK's seven leading alcohol companies including Whitbread, Bass and Seagram, launched a new PR organisation from the headquarters of Guinness plc in London's Portman Square" [1].

The Portman Group's publicly stated aim is "to promote sensible drinking" However, according to Professor Nick Heather, former Director of the Newcastle Centre for Alcohol and Drug Studies, the Group's real agenda is rather different: "The attempt to distance alcohol as a drug from other kinds of drug and to give it a good face is the main activity of groups like the Portman Group." [2]

Read Full Profile

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Nick Heather on controlled drinking and the relationship to harm reduction


Nick distinguishes between harm reduction and harm elimination. He describes the way in which views of harm reduction in the USA have ‘muddied the waters’ in relation to the goal of controlled drinking. Nick says that the controlled drinking goal in the alcohol field may have been watered down more recently by the influence of the concept of harm reduction from the illicit drugs field.

View Video
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Nick Heather explores harmful choices and explains Hyperbolic Discounting


Nick references George Ainslie’s work on ‘pico-economics’ and ‘breakdown of will’. He explains the idea of hyperbolic discounting and how this related to addiction. He also explores the concepts of resolutions and preferences and how these relate to our understanding of addiction.

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Nick Heather on Motivational Interviewing pre-comittment and Ulysses


Nick talks about the theory of how people resist temptation by findings ways of increasing the value later, larger rewards relative to earlier, smaller rewards, as described in the work of Jon Elster and George Ainslie..

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Nick Heather: Alcohol is not an ordinary commodity


Nick says we demonise illicit drugs use to irrational levels but equally we underestimate the harmful effects of alcohol.

He goes on the discuss ways of reducing alcohol-related harm by pricing. Controlling the alcohol industry and reducing health inequalities.

View Film
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Wednesday, January 6, 2010

Nick Heather on 'Choice, Behavioural Economics and Addiction


Nick describes the background of a conference he convened with Rudy Vuchinich on behavioural economics and its relevance to addiction, and the book that arose from this conference.

He also talks about Alcoholics Anonymous and how its benefits could be applied to secular mutual-aid groups.

He then references the work of Keith Humphreys on self-help groups.


View Film

Monday, January 4, 2010

Brief motivational feedback for college students and adolescents: a harm reduction approach


Alcohol consumption and its attendant problems are prevalent among adolescents and young adult college students. Harm reduction has been found efficacious with heavy drinking adolescents and college students.

These harm reduction approaches do not demand abstinence and are designed to meet the individual where he or she is in the change process.

The authors present a case illustration of a harm reduction intervention, the Brief Alcohol Screening and Intervention for College Students (BASICS), with a heavy-drinking female college student experiencing significant problems as a result of her drinking.

BASICS is conducted in a motivational interviewing style and includes cognitive-behavioral skills training and personalized feedback.

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Request Reprint E-Mail: ursulawhiteside@gmail.com
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Adolescents alcohol-use and economic conditions: a multilevel analysis of data from a period with big economic changes


This paper examines how the unemployment rate is related to adolescent alcohol use and experience of binge drinking during a time period characterized by big societal changes.

The results show that the unemployment rate is negatively associated with adolescents’ alcohol use and the experience of binge drinking. When the unemployment rate increases, more adolescents do not drink at all. Regular drinking (twice per month or more) is, on the other hand, unrelated to the unemployment rate.

Examining gender-differences in the relationship, it is shown that the results are driven by behavior in girls, whereas drinking among boys does not show any significant relationship with changes in the unemployment rate.


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Request Reprint E-Mail: mikael.svensson@oru.se
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Challenging the “Inoffensiveness” of Regular Cannabis Use by Its Associations with Other Current Risky Substance Use—A Census of 20-Year-Old Swiss Men


3,537 men enrolling in 2007 for mandatory army recruitment procedures were assessed for the co-occurrence of risky licit substance use among risky cannabis users.

Risky cannabis use was defined as at least twice weekly; risky alcohol use as 6+ drinks more than once/monthly, or more than 20 drinks per week; and risky tobacco use as daily smoking.

Ninety-five percent of all risky cannabis users reported other risky use. They began using cannabis earlier than did non-risky users, but age of onset was unrelated to other risky substance use.

A pressing public health issue among cannabis users stems from risky licit substance use warranting preventive efforts within this age group.


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Alcohol, Other Drugs, and Health: Current Evidence

Current Issue: November–December 2009

Interventions and Assessments

Health Outcomes

Slide Presentations


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Friday, January 1, 2010

Age-period-cohort modelling of alcohol volume and heavy drinking days in the US National Alcohol Surveys: Divergence in younger and older adult trends


The decomposition of trends in alcohol volume and heavy drinking days into age, period, cohort and demographic effects offers an important perspective on the dynamics of change in alcohol use patterns in the US.

Trend analyses show that while mean values of drinking measures have continued to decline for those aged 26 and older, there has been a substantial increase in both alcohol volume and 5+ days among those aged 18 to 25. Age-period-cohort models indicate a potential positive cohort effect among those born after 1975. However, an alternative interpretation of an age-cohort interaction where drinking falls off more steeply in the late twenties than was the case in the oldest surveys cannot be ruled out. For women only, the 1956–60 birth cohort appears to drink more heavily than those born just before or after. Models also indicate the importance of income, ethnicity, education and marital status in determining these alcohol measures.

Increased heavy drinking among young adults in recent surveys presents a significant challenge for alcohol policy and may indicate a sustained increase in future US alcohol consumption.

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PROOF-OF-CONCEPT HUMAN LABORATORY STUDY FOR PROTRACTED ABSTINENCE IN ALCOHOL DEPENDENCE: EFFECTS OF GABAPENTIN


There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence in alcoholics that may precipitate relapse e.g., craving and disturbances in sleep and mood.

This proof-of-concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non treatment-seeking sample of cue-reactive, alcohol-dependent individuals.

Subjects were 33 paid volunteers with current DSM-IV alcohol dependence and a strength of craving rating 1σ or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1-week and then participated in a within-subjects trial where each was exposed to standardized sets of pleasant, neutral, and unpleasant visual stimuli followed by alcohol or water cues.

We found a significant attenuating effect of gabapentin (vs. placebo) on several measures of subjective craving for alcohol as well as for affectively-evoked craving. Gabapentin was also found to significantly improve several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs.

Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and, hence, that a randomized clinical trial would be an appropriate next step.

The study also suggests the value of cue reactivity studies as proof-of-concept screens for potential anti relapse drugs.


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Estimating risk of alcohol dependence using alcohol screening scores


Brief alcohol counseling interventions can reduce alcohol consumption and related morbidity among non-dependent risky drinkers, but more intensive alcohol treatment is recommended for persons with alcohol dependence.

This study evaluated whether scores on common alcohol screening tests could identify patients likely to have current alcohol dependence so that more appropriate follow-up assessment and/or intervention could be offered.

Based on the prevalence of past-year alcohol dependence in this sample (men: 12.2%; women: 5.8%), zones of the AUDIT and AUDIT-C identified wide variability in the post-screening risk of alcohol dependence in men and women, even among those who screened positive for alcohol misuse.

Among men, AUDIT zones 5–10, 11–14 and 15–40 were associated with post-screening probabilities of past-year alcohol dependence ranging from 18 to 87%, and AUDIT-C zones 5–6, 7–9 and 10–12 were associated with probabilities ranging from 22 to 75%.

Among women, AUDIT zones 3–4, 5–8, 9–12 and 13–40 were associated with post-screening probabilities of past-year alcohol dependence ranging from 6 to 94%, and AUDIT-C zones 3, 4–6, 7–9 and 10–12 were associated with probabilities ranging from 9 to 88%.

AUDIT or AUDIT-C scores could be used to estimate the probability of past-year alcohol dependence among patients who screen positive for alcohol misuse and inform clinical decision-making.

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Request Reprint E-Mail: Anna.Rubinsky@va.gov

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Association of SOD2, a Mitochondrial Antioxidant Enzyme, with Gray Matter Volume Shrinkage in Alcoholics


Chronic alcoholism leads to gray matter shrinkage and induces the formation of superoxide anions (O2−) that can cause neuronal cell death. The mitochondrial superoxide dismutase 2 (SOD2) enzyme is critical in the metabolism of superoxide. An Ala16Val polymorphism putatively affects SOD2 enzyme activity in vivo.

Brain volumes of 76 treatment-seeking alcohol-dependent individuals were measured with a 1.5T MRI. Intracranial tissue margins were manually outlined on coronal sections. Gray matter, white matter, sulcal, and ventricular CSF volumes were estimated using intensity-based K-means clustering. Ala16Val (rs4880) and a second haplotype tagging SNP, rs10370, were genotyped. The q-value package was used to correct for multiple comparisons.


In the alcoholics, cerebrospinal fluid and intra-cranial volumes showed significant differences across the six diplotype categories. The homozygous Ala16-containing diplotype rs10370TT-rs4880GG was associated with lowest gray matter ratio (greater shrinkage; p=0.005). Presence of one or two copies of the low activity Ala16 allele was a risk factor for lower gray matter volume in alcoholics below the median alcohol consumption (p=0.03) but not in alcoholics above this level. White matter ratio was associated with sex (p=0.002) and lifetime total alcohol consumption (p=0.01) but not with diplotypes.

In this exploratory analysis, a putative functional missense variant of SOD2 appears to influence gray matter loss in alcoholics. This may be due to impaired clearance of reactive oxygen species formed as a result of alcohol exposure.

The risk/protective effect was observed in alcoholics with lower levels of lifetime alcohol consumption. Highest levels of exposure may overwhelm the protective action of the SOD2 enzyme.

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Request Reprint E-Mail: srivastavav@mail.nih.gov
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Too much of the hard stuff: what alcohol costs the NHS


Consumption of alcohol in the UK has increased by 19 per cent over the last three decades and is now higher than in any other European country. Recent reports indicate that 10.5 million adults in England drink above sensible limits and around 1.1 million have a level of alcohol addiction. Alcohol is the third leading cause of disease burden in developed countries and, as a result, the cost of providing alcohol-related services is escalating. The burden on the NHS will be unsustainable if this continues.

This Briefing, produced with the Royal College of Physicians, outlines the extent of the problem and gives examples of where the NHS is managing problem drinkers effectively and efficiently. The NHS Confederation visited hospitals between August and November 2009 and gathered evidence from members to gain an understanding of the extent of the burden and the ways in which hospitals can improve their services.

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News Release - NIH Opportunity Network to Expand Basic Behavioral and Social Sciences Research


National Institutes of Health (NIH) Director Francis Collins, M.D., Ph.D., today announced the launch of the Basic Behavioral and Social Science Opportunity Network (OppNet), a trans-NIH initiative to expand the agency’s funding of basic behavioral and social sciences research (b-BSSR).

The b-BSSR field studies mechanisms and processes that influence behavior at the individual, group, community and population level. Research results lead to new approaches for reducing risky behaviors and improving the adoption of healthy practices. . . . . .

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Russia fixes minimum vodka price


Russia introduced on Friday a minimum price of vodka in an effort to fight counterfeit alcohol production in the country.

From January 1, any 0.5l vodka bottle selling at below 89 rubles (almost $3) will be outlawed. The price ban is one of the first government steps toward regulating the domestic alcohol market.

First Deputy Prime Minister Viktor Zubkov said earlier other measures in the sphere would be accomplished by July 1, 2010. Theses include the licensing of alcohol supplies, the introduction of a unified excise duty on alcohol, and tougher responsibility for the production and marketing of fake vodka.
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