Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Thursday, April 24, 2008

On Wit, Irony, and Living With Imperfection: How Britain Said No to Abstinence
May 2008, Vol 98, No. 5 | American Journal of Public Health 814-822

Christian perfection, the evangelical doctrine that gave rise to abstinence as it is understood and practiced in America, originated in Britain with John Wesley and the Methodists.

We examine why that doctrine floundered in its country of origin, opening the door to a more pluralistic and evidence-based approach to problems such as alcohol and drug abuse.

Although social and political factors were important (the stratification of British society stood in the way of holding everyone to the same moral standard, and the drink trade was far better organized than its American counterpart), Britain’s intellectual elite also played a vital role, heaping ridicule on the temperance movement and subjecting it to a devastating critique.

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Request Reprint E-Mail: jessica_warner@camh.net
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Education and race-ethnicity differences in the lifetime risk of alcohol dependence
Journal of Epidemiology and Community Health
2008;62:224-230


While lower socioeconomic status (SES) is related to higher risk for alcohol dependence, minority race-ethnicity is often associated with lower risk. This study attempts to clarify the nature and extent of social inequalities in alcohol dependence by investigating the effects of SES and race-ethnicity on the development of alcohol dependence following first alcohol use.

Compared with non-Hispanic white people, age-adjusted and sex-adjusted risks of alcohol dependence were lower among black people (odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.63 to 0.78), Asians (OR = 0.65, CI = 0.49 to 0.86) and Hispanics (OR = 0.68, CI = 0.58 to 0.79) and higher among American Indians (OR = 1.37, CI = 1.09 to 1.73). Individuals without a college degree had higher risks of alcohol dependence than individuals with a college degree or more; however, the magnitude of risk varied significantly by race-ethnicity ({chi}2 for the interaction between education and race-ethnicity = 19.7, df = 10, p = 0.03); odds ratios for less than a college degree were 1.12, 1.46, 2.24, 2.35 and 10.99 among Hispanics, white people, black people, Asians, and American Indians, respectively. There was no association between education and alcohol dependence among Hispanics.

Race-ethnicity differences in the magnitude of the association between education and alcohol dependence suggest that aspects of racial-ethnic group membership mitigate or exacerbate the effects of social adversity.

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Request Reprint E-Mail: sgilman@hsph.harvard.edu

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Wednesday, April 23, 2008

Working with hotels and clubs to reduce alcohol-related crime


Auditor-General's report: performance aud

This audit assessed how well the NSW Police Force (Police) and the Office of Liquor, Gaming and Racing (OLGR) work with licensees to promote and enforce RSA to reduce alcohol-related crime.

Audit opinion

In NSW alcohol-related assaults have almost doubled over the last ten years. In 2006-07 there were 20,475 alcohol related assaults excluding domestic violence incidents, up from 10,305 in 1997-98. Incidences of alcohol-related malicious damage and offensive conduct have also
increased, rising by 87 and 70 per cent respectively. However we found that the number of alcohol-related assaults has reduced or stabilised in the last two years in about 14 per cent of Police local area commands. Of the four commands we visited, alcohol-related assaults had
stabilised in two, and significantly reduced last year in another. OLGR has also had some success in reducing assaults in a number of licensed premises.

In Brief

Foreword

Executive Summary

Recommendations

Download full report

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Consumer/Health Groups Unite in Pressing for a Final Rule Mandating a Standardized, Useful Alcohol Facts Label

White Paper and Ad Campaign Put Issue in Front of Policymakers;
New Poll Finds Consumers Want Government to Act

Sally Greenberg's remarks

Release Date: April 22, 2008
Contact: 202-835-3323,
media@nclnet.org

Washington, D.C.-- A coalition of public interest groups today called for the federal government to end 30 years of “deliberations and fact finding” by issuing a useful final regulation to require standardized labeling information on beer, wine and distilled spirits products.

At a news conference in Washington, members of a broad-based coalition of public health leaders and consumer advocacy organizations used the occasion of Alcohol Awareness Month to release a white paper laying out the need for an easy-to-read, standardized label that will provide consumers with complete information about alcohol and calorie content per serving. Issued as a nationwide call to action, the white paper concludes that easily accessible alcohol labeling can play an important role in reducing alcohol abuse, drunk driving, and the many diseases attributable to excessive alcohol intake, such as liver cirrhosis and cancers of the upper gastrointestinal tract.

To highlight this issue for federal policymakers, Shape Up America! -- the anti-obesity crusade launched by former Surgeon General C. Everett Koop -- also unveiled a newspaper advertising campaign featuring an open letter to Treasury Secretary Henry Paulson signed by 18 organizations and public health officials. The open letter cites more than 30 years of delay by Alcohol and Tobacco Tax and Trade Bureau (TTB) and its predecessor agency, the Bureau of Alcohol, Tobacco and Firearms (BATF), in responding to public pressure, several petitions, and court challenges, none of which has produced a government rule requiring an easy-to-read, standardized label on all alcoholic beverages.
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Read Full Press Release


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New Research Shows Public Wants Alcohol Content Listed On Labels for Beer, Wine and Distilled Spirits
Top Priority for Consumers Is Knowing Amount of Alcohol in Each Drink; Data to Be Sent to Alcohol and Tobacco Tax and Trade Bureau (TTB)




Washington, DC; January 22, 2008 – As the Treasury Department’s Alcohol and Tobacco Tax and Trade Bureau (TTB) considers public comments on proposed rules to require standardized labeling information on beer, wine and distilled spirits, a new survey filed today as part of the public record underscores the importance of mandating detailed information about the alcohol content of these products – something TTB’s current proposals do not require.

Conducted for Shape Up America!, by Penn, Schoen and Berland’s (PSB) Internet Surveys Group (ISG), the online survey of 503 adult Americans aged 18 and over provides compelling evidence that consumers want complete labeling information on alcoholic beverages, including the percentage of alcohol by volume, the serving size, the amount of alcohol per serving, the definition of a “standard drink,” and the number of standard drinks per container. In fact, eight in ten of those polled (79 percent) agreed with the statement: “There is no point in having labeling on the containers of alcohol beverages unless labels include all nutrition and ingredient information, including the amount of alcohol in each drink.”
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Survey findings (PDF)

Press release (PDF)
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Report of the Government Alcohol Advisory Group Publisher:'Report of the Government Alcohol Advisory Group': Department of Justice, Equality and Law Reform
23 Apr 2008

This Group was established by the Minister for Justice, Equality & Law Reform to advise Government on certain matters relating to the sale and consumption of alcohol with a particular focus on the effect alcohol had on public order offences.

Download 'Report of the Government Alcohol Advisory Group'

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Press Release - Taoiseach and Minister for Justice announce new measures to tackle binge drinking & public disorder
23 April 2008

The Taoiseach, Mr Bertie Ahern, T.D. and the Minister for Justice, Equality and Law Reform, Mr Brian Lenihan, T.D., today announced new legislative measures to tackle the increasing availability and excessive consumption of alcohol, and the public order problems caused by binge drinking.

The draft legislation, the Intoxicating Liquor/Public Order Bill 2008, proposes the reform of both licensing law and public order legislation in response to recommendations contained in the Report of the Alcohol Advisory Group also being published today. Drafting of the Bill is at an advanced stage with a view to its enactment before the Oireachtas rises for the summer break.

Speaking at today’s event the Taoiseach and Minister Lenihan both congratulated Dr Gordon Holmes, chair of the Advisory Group, and the other members of the Group for prompt delivery of an excellent report. The legislative measures announced today are the first step in implementing the Group’s recommendations and taking action to deal with the problem of binge drinking and the public order problems it causes.
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Read Full Release

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Study finds driving under the influence trends North

Published: April 23, 2008

WASHINGTON (AP) -- The upper Midwest has the worst drunken driving rates in the country, according to a government report that says 15 percent of adult drivers nationally report driving under the influence of alcohol in the previous year.

Wisconsin leads the way. The federal government estimates more than a quarter of the state's adult drivers had driven under the influence. Rounding out the worst five are North Dakota, Minnesota, Nebraska and South Dakota.

Utah had the lowest incidence of drunken driving. It was the only state where fewer than 10 percent of adult motorists reported driving under the influence. Following closely behind were a slew of Southern states that often fare poorly when it comes to government health statistics. This time, however, they're serving as models. West Virginia, Arkansas, Kentucky and North Carolina all had drunken driving rates for the prior year of less than 11 percent.
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Genetic approaches to addiction: genes and alcohol
Addiction OnlineEarly Articles 16 April 2008


Alcoholism is a chronic relapsing disorder with an enormous societal impact. Understanding the genetic basis of alcoholism is crucial to characterize individuals' risk and to develop efficacious prevention and treatment strategies.

We examined the available scientific literature to provide an overview of different approaches that are being integrated increasingly to advance our knowledge of the genetic bases of alcoholism. Examples of genes that have been shown to influence vulnerability to alcoholism and related phenotypes are also discussed.

Genetic factors account for more than 50% of the variance in alcoholism liability. Susceptibility loci for alcoholism include both alcohol-specific genes acting either at the pharmacokinetic or pharmacodynamic levels, as well as loci moderating neuronal pathways such as reward, behavioral control and stress resiliency, that are involved in several psychiatric diseases.

In recent years, major progress in gene identification has occurred using intermediate phenotypes such as task-related brain activation that confer the advantage of increased power and the opportunity of exploring the neuronal mechanisms through which genetic variation is translated into behavior.

Fundamental to the detection of gene effects is also the understanding of the interplay between genes as well as genes/environment interactions. Whole Genome Association studies represent a unique opportunity to identify alcohol-related loci in hypothesis-free fashion.

Finally, genome-wide analyses of transcripts and chromatin remodeling promise an increase in our understanding of the genome function and of the mechanisms through which gene and environment cause diseases.

Although the genetic bases of alcoholism remain largely unknown, there are reasons to think that more genes will be discovered in the future. Multiple and complementary approaches will be required to piece together the mosaic of causation.

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Request Reprint E-Mail: francesca.ducci@iop.kcl.ac.uk

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Alcoholism leads to early perceptive alterations, independently of comorbid depressed state: An ERP study
Neurophysiologie Clinique/Clinical Neurophysiology Volume 38, Issue 2, April 2008, Pages 83-97

Alcoholism is associated with a deficit in the processing of emotional facial expressions (EFE) and with a delayed P3b component, partially mediated by earlier perceptive deficits (P100, N170). Since alcohol dependence often occurs with depression, we aim at investigating whether classical event-related potentials (ERP) alterations observed in alcoholism are modulated or not by depression.

At the behavioural level, control participants discriminated EFE (but not gender) more rapidly than the three other groups. At the ERP level, the differences observed on RTs for emotional task were neurophysiologically indexed by a delayed P3b component. This delay was associated with earlier ERP alterations (P100, N100, N170), but only in participants suffering from alcohol dependence, in association or not with depression.

On the one hand, individuals with alcoholism, associated or not with a comorbid depression, were impaired in the processing of EFE. This deficit was neurophysiologically indexed by early perceptive (P100, N100, N170) and decisional (P3b) alterations. On the other hand, non-alcoholic patients with depression only exhibited P3b impairment.

These results lead to potential implications concerning the usefulness of the ERP for the differential diagnosis in psychiatry, notably concerning the comorbidities in alcoholism.

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Request Reprint E-Mail: pierre.maurage@uclouvain.be

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Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
Pharmacology Biochemistry and Behavior Volume 89, Issue 4, June 2008, Pages 481-498



The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats.

For the ACB, there were 513 significant differences at the p <>p <>p <>Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.

Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH.

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Request Reprint E-Mail: zrodd@iupui.edu
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News Release - Environment influences when drinking begins; genes' role increases in transition to alcohol dependence

By Jim Dryden

April 22, 2008 -- The influence of genetics increases as young women transition from taking their first drink to becoming alcoholics. A team of researchers at Washington University School of Medicine in St. Louis found that although environment is most influential in determining when girls begin to drink, genes play a larger role if they advance to problem drinking and alcohol dependence.

The researchers studied 3,546 female twins ages 18 to 29 to ferret out the influences of genes and environment in the development of alcohol dependence. Their findings appear in the April issue of Alcoholism: Clinical & Experimental Research.
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Genetic Dissociation of Ethanol Sensitivity and Memory Formation in Drosophila melanogaster
Genetics, Vol. 178, 1895-1902, April 2008,


The ad hoc genetic correlation between ethanol sensitivity and learning mechanisms in Drosophila could overemphasize a common process supporting both behaviors.

To challenge directly the hypothesis that these mechanisms are singular, we examined the learning phenotypes of 10 new strains. Five of these have increased ethanol sensitivity, and the other 5 do not.

We tested place and olfactory memory in each of these lines and found two new learning mutations. In one case, altering the tribbles gene, flies have a significantly reduced place memory, elevated olfactory memory, and normal ethanol response. In the second case, mutation of a gene we name ethanol sensitive with low memory (elm), place memory was not altered, olfactory memory was sharply reduced, and sensitivity to ethanol was increased.

In sum, however, we found no overall correlation between ethanol sensitivity and place memory in the 10 lines tested. Furthermore, there was a weak but nonsignificant correlation between ethanol sensitivity and olfactory learning. Thus, mutations that alter learning and sensitivity to ethanol can occur independently of each other and this implies that the set of genes important for both ethanol sensitivity and learning is likely a subset of the genes important for either process.


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Request Reprint E-Mail: zarst@missouri.edu
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State Estimates of Persons Aged 18 or Older Driving Under the Influence of Alcohol or Illicit Drugs
Highlights:
  • Based on SAMHSA's National Survey on Drug Use and Health, in 2006 an estimated 30.5 million persons aged 12 or older reported driving under the influence of alcohol at least once in the past year and 10.2 million reported driving under the influence of illicit drugs during the past year. Illicit drugs included marijuana/hashish, cocaine, crack cocaine, inhalants, hallucinogens, heroin, or prescription-type drugs used nonmedically.
  • Combined data from SAMHSA's 2004 to 2006 National Surveys on Drug Use and Health were used to produce average annualized data on driving under the influence of alcohol or illicit drugs in the past year for each State based on self reports by adults aged 18 or older.
  • Based on the combined 2004 to 2006 National Surveys on Drug Use and Health data from current drivers aged 18 or older, 15.1% had driven under the influence of alcohol during the past year and 4.7% had driven under the influence of illicit drugs.
  • States with the highest rates of driving under the influence of alcohol in the past year among adults aged 18 or older were Wisconsin (26.4%), North Dakota (24.9%), Minnesota (23.5%), Nebraska (22.9%), and South Dakota (21.6%).
  • The highest rates of driving under the influence of illicit drugs in the past year among adults aged 18 or older were in the District of Columbia (7.0%), Rhode Island (6.8%), Massachusetts (6.4%), Montana (6.3%), and Wyoming (6.2%).
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Blacks Have Much Lower Incidence of Alcohol Abuse than Whites
By Michael Smith, North American Correspondent,
MedPage Today
Published: April 22, 2008


BETHESDA, Md., April 22 -- Blacks are 40% less likely than whites to develop alcohol abuse and Hispanics are half as likely as whites to develop generalized anxiety disorder.

These are among the few surprises in a major study of the incidence of such disorders, reported Bridget Grant, Ph.D., of the National Institute on Alcohol Abuse and Alcoholism, and colleagues online today in Molecular Psychiatry.
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Read Full Article and View Audio Report
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Sociodemographic and psychopathologic predictors of first incidence of DSM-IV substance use, mood and anxiety disorders: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions
Molecular Psychiatry advance online publication 22 April 2008



The objective of this study was to present nationally representative findings on sociodemographic and psychopathologic predictors of first incidence of Diagnostic and Statistical Manual of Mental Disorders, 4th edn (DSM-IV) substance, mood and anxiety disorders using the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions.

One-year incidence rates of DSM-IV substance, mood and anxiety disorders were highest for alcohol abuse (1.02), alcohol dependence (1.70), major depressive disorder (MDD; 1.51) and generalized anxiety disorder (GAD; 1.12).

Incidence rates were significantly greater (P<0.01) among men for substance use disorders and greater among women for mood and anxiety disorders except bipolar disorders and social phobia. Age was inversely related to all disorders. Black individuals were at decreased risk of incident alcohol abuse and Hispanic individuals were at decreased risk of GAD. Anxiety disorders at baseline more often predicted incidence of other anxiety disorders than mood disorders. Reciprocal temporal relationships were found between alcohol abuse and dependence, MDD and GAD, and GAD and panic disorder. Borderline and schizotypal personality disorders predicted most incident disorders.

Incidence rates of substance, mood and anxiety disorders were comparable to or greater than rates of lung cancer, stroke and cardiovascular disease. The greater incidence of all disorders in the youngest cohort underscores the need for increased vigilance in identifying and treating these disorders among young adults.

Strong common factors and unique factors appear to underlie associations between alcohol abuse and dependence, MDD and GAD, and GAD and panic disorder.

The major results of this study are discussed with regard to prevention and treatment implications.

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Request Reprint E-Mail: bgrant@willco.niaaa.nih.gov
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Systems Biology - The Solution to Understanding Alcohol-Induced Disorders?
Volume 31, Number 1, 2008





IN THIS ISSUE



COMMENTARY: SYSTEMS BIOLOGY AND ITS RELEVANCE TO ALCOHOL RESEARCH (PDF)

The effects of alcohol on the body are complex and can be studied on an environmental as well as intrinsic level. Alcohol-induced disorders, including organ damage and addiction, reflect the genetic and epigenetic makeup and the cumulative responses to alcohol exposure over time. At the molecular level, the effects of alcohol and its metabolites are the consequences of changes in DNA, RNA, proteins, metabolites, and other molecules. At the systems level, alcohol affects a variety of organs, biochemical or signaling pathways, and biological processes. This article by Drs. Q. Max Guo and Sam Zakhari is a commentary on the benefits of studying the effects of alcohol abuse using a systems biology approach. Alcohol research using a systems biology approach will prove fruitful in unraveling the mechanisms of complex alcohol-induced disorders.

NIH ROADMAP FOR MEDICAL RESEARCH (PDF)

In an effort to transform the Nation’s medical research capabilities and improve the translation of research into practice, the National Institutes of Health has designed a Roadmap for Medical Research, consisting of three major themes—new pathways to discovery, research teams of the future, and reengineering the clinical research enterprise. This sidebar by Ms. Lori Wolfgang Kantor describes the initiatives within each theme.


SYSTEMS GENETICS OF ALCOHOLISM (PDF)

Alcoholism results from a complex interaction of genetic as well as environmental and social factors. Increasing interest in the heritability of alcoholism has resulted in numerous studies of how single genes, as well as an individual’s entire genetic content, influence alcoholism risk. This article by Ms. Chantel D. Sloan, Ms. Vicki Sayarath, and Dr. Jason H. Moore examines how technological and statistical tools can be used to further the understanding of alcoholism’s genetic basis as well as key findings from candidate gene and genome-wide studies. These studies confirm the role of genetics in the development of alcoholism and elucidate the need for a systems-based approach to the study of the genetic basis of the disease.

METABOLOMICS IN ALCOHOL RESEARCH AND DRUG DEVELOPMENT (PDF)

Metabolomics—a systems biology approach to characterizing metabolites produced in biochemical pathways—has contributed to many studies of disease progression and treatment. Metabolomic approaches are particularly useful because the metabolome— the entire set of all metabolites in a cell or tissue—represents the cell’s or tissue’s functional status more closely than, for example, the genome, because it responds to induced chemical or environmental changes and reflects the overall effects of all genetic and environmental alterations. The article by Drs. George G. Harrigan, Greg Maguire, and Laszlo Boros discusses how metabolomic approaches also may be applicable in alcohol research, using the examples of lipid metabolism and of metabolic pathways involving the vitamin thiamine, both of which are altered by excessive alcohol use. By further increasing the number and types of metabolites that can be measured in a given biological sample, metabolomic approaches may be able to help define the role of the many different metabolic pathways impacted by alcohol abuse and provide a means to support discovery and development of novel medications for the treatment of alcoholism and related conditions.

PROTEOMIC APPROACHES FOR STUDYING ALCOHOLISM AND ALCOHOL-INDUCED ORGAN DAMAGE (PDF)

Proteomics research—the study of all the proteins in a cell, tissue, or organism—increasingly is being used in alcohol research to study alcohol’s effects on the body. This article by Dr. Susanne Hiller-Sturmhöfel, Mr. Josip Sobin, and Dr. R. Dayne Mayfield introduces numerous proteomic approaches, including shotgun strategies, assays to determine protein–protein interactions, and in silico analyses. All of these strategies are being used to identify the proteins that are affected by alcohol. Moreover, the results of such analyses may help in the identification of biomarkers of alcoholism and susceptibility to alcohol-induced tissue damage as well as of proteins that may eventually become therapeutic targets for alcoholism.

MATHEMATICAL MODELING OF COMPLEX BIOLOGICAL SYSTEMS: FROM PARTS LISTS TO UNDERSTANDING SYSTEMS BEHAVIOR (PDF)

Recent technological advances that allow for processing of numerous samples simultaneously have enabled researchers to monitor complex cellular processes on a molecular level. This article by Hans Peter Fischer discusses mathematical and computational model approaches to systems biology. The article explores the “-omics” technologies—transcriptomics, proteomics, and metabolomics. The information gained from these experimental approaches should shed new light on the biochemical reactions that control functions such as metabolism, cell growth, reproduction, and the stress response.

SYSTEMS BIOLOGY IN THE STUDY OF NEUROLOGICAL DISORDERS: FOCUS ON ALZHEIMER’S DISEASE (PDF)

Excessive alcohol use adversely affects brain functioning and is associated with certain neurological disorders. Although systems biology approaches are not yet being used extensively in the study of alcohol-related neurological disorders, they have been used in the study of other neurological conditions such as Alzheimer’s disease, which increasingly is becoming a major public health concern. Researchers using systems biological approaches to study the development and progression of this degenerative disease have discovered several genes whose expression already is altered in patients exhibiting the disease’s earliest stages. This article by Drs. Giulio M. Pasinetti and Susanne Hiller-Sturmhöfel discusses systems biology approaches, such as cDNA microarrays, protein array studies, and proteomic approaches, for studying Alzheimer’s disease, potential genes involved in its development, as well as the mechanisms underlying alcohol’s harmful effects on the brain and its consequences.

ALCOHOLIC LUNG DISEASE (PDF)

Alcohol abuse has long been linked to an increased risk for lung infection (i.e., pneumonia). However, recent studies have shown that alcohol abuse also increases the risk of acute lung injury following major trauma, such as a serious motor vehicle accident, gunshot wound, or other event requiring hospitalization or when there is a risk of the spread of bacteria attributed to infection. This article by Drs. Corey D. Kershaw and David M. Guidot reviews recent studies that have found genetic analysis to be helpful in identifying potential candidate genes involved in alcohol-induced lung dysfunction, which might explain the newly identified association between alcohol abuse and acute lung injury in humans.

A SYSTEMS-BASED COMPUTATIONAL MODEL OF ALCOHOL’S TOXIC EFFECTS ON BRAIN DEVELOPMENT (PDF)

Exposure of the growing fetus to alcohol in utero can cause a broad range of potential neurological disorders, ranging from alcohol-related neurodevelopmental disorder at the lowest exposure levels to fetal alcohol syndrome at the highest level. This article by Drs. Julia M. Gohlke, Susanne Hiller-Sturmhöfel, and Elaine M. Faustman discusses the effects of alcohol on nerve cell development (i.e., neurogenesis) and the formation of their connections with neighboring cells (i.e., synaptogenesis). Systems-based approaches, such as the generation of computational models to determine the relative effects of alcohol on various processes during brain development, can help to translate research findings obtained at a molecular or cellular level into assessment of risk associated with prenatal alcohol exposure.

GLOSSARY [PDF]

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50 Best Collection on Alcohol Harm Reduction


With this project, the International Harm Reduction Association (IHRA) aims to identify and collect approximately 50 documents that provide the best information on the subject of alcohol harm reduction. This will create a thorough and broad information base on this topic, with papers representative of a range of sub-topics and research and papers from around the world. This project is the first major output from IHRA’s new
Global Alcohol Harm Reduction Network (GAHR-Net) – a free network designed to provide a forum for researchers, advocates, practitioners, policy makers and communities to discuss practical alcohol harm reduction interventions and policy options. Through this document collection, GAHR-Net and the dedicated alcohol pages on the IHRA website, IHRA aims to push the alcohol harm reduction field forward - connecting those who support or practice alcohol harm reduction, developing a sense of belonging and community, and facilitating discussions. This is the latest in a series of “50 Best Collections” commissioned or managed by IHRA.
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Tuesday, April 22, 2008

Elderly drinkers may be putting themselves at risk|Tribune reporter
22 April 2008
The 71-year-old former community college teacher was struggling in her retirement. She missed her job. Divorced and living alone, with her children far away, she felt increasingly isolated and lonely.

As boredom and depression sunk in, she turned more and more to alcohol for solace.
But her drinking presented a whole new set of problems. The retired Chicago teacher stopped eating and lost weight, and she fell several times, injuring herself.

With the nation's population graying, health professionals have grown increasingly concerned about the number of people 65 and older who drink unhealthy amounts of alcohol.

A recent study published in the Journal of the American Geriatrics Society reported that 9 percent of elderly Medicare beneficiaries—16 percent of the men and 4 percent of the women—engaged in unhealthy drinking. Researchers said those numbers could be conservative because they are based on self-reporting.
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For Women, the Wineglass Is Half Full
Washington Post


Tuesday, April 22, 2008; Page HE01

Raising a glass of wine and wishing "Salud!" -- Health! -- is one of life's many pleasures.

But for women, this well-meaning cheer rings hollow: There's mounting evidence that drinking wine and other alcoholic beverages increases the risk of breast cancer.

That's not the image that many people have about sipping wine, beer or other alcoholic beverages in moderation. A recent Harvard study of 878 people found that nearly two-thirds of drinkers and about a third of teetotalers considered such imbibing to be safe and healthful. So healthful that about 30 percent of those surveyed said the purported health benefits of alcohol are one reason they drink.

The link between alcohol and breast cancer is something that "almost nobody in the study had heard about," says the survey's lead author, Kenneth Mukamal, an internist at Beth Israel Deaconess Hospital in Boston. Only 10 percent correctly identified breast cancer as a possible risk of moderate drinking, the researchers reported in the journal Family Medicine.
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News Releas - HSE Publishes Detailed Review of Alcohol Consumption Rates and Related Harms

21st April 2008

The Health Service Executive (HSE), today, Monday 21st April, published a detailed review entitled "Alcohol Related Harm in Ireland." The report outlines the recent rising trends in alcohol consumption rates, the harmful effects these rates are having on the user and the damaging results they have on other people.

The report provides an overview of recent studies into alcohol consumption, assesses the most up to date research into their effects and offers recommendations on how best to reduce the unhealthiest consequences.

Following four years of static alcohol consumption, in 2007 there was a rise of 2.7% per capita in individual alcohol consumption.

Some of the key findings of the report include:

Alcohol Related Harm to the Drinker:

  • 28% of all injury attendances in Accident and Emergency Departments in acute hospitals were alcohol related;
  • Alcohol related hospital discharges, which is an indicator of attendance, increased by 92% between 1995 and 2002;
  • Cancer of the liver had the highest increase in cancer incidence rates in comparison to all cancers between 1994-2003;
  • Almost half of men and over a quarter of women agreed that drinking alcohol had contributed to them having sex without contraception;
  • Between 1995 and 2004, Sexually Transmitted Infections (STIs) increased by 217%;
  • Alcohol is a contributory factor in 36.5% of all fatal crashes;
  • Between 1996 and 2002, public order adult offences increased by 247% (from 16,284 to 56,822) followed by a decrease in 2003 and 2004 but increased again in 2005;

Alcohol Related Harm to Others:

  • Almost half (46%), of those who committed homicide were intoxicated at the time;
  • Between 1990 and 2006, 2,462 people were killed on the roads between 9pm-4am, the time most associated with alcohol related driving;
  • 44% of all respondents had experienced harm by their own or someone else's alcohol use;
  • In a quarter of severe domestic abuse cases, alcohol was involved;
  • The Coombe Women's Hospital found that 63% of women reported alcohol use during pregnancy, with 7% drinking 6 or more drinks per week;
  • IBEC cited that alcohol related illness was cited by 12% of companies as a cause of short-term absence from work for males and 4% for females;
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Monday, April 21, 2008

Effects of craving and DRD4 VNTR genotype on the relative value of alcohol: an initial human laboratory study
Behav Brain Funct. 2007; 3: 11.

Craving for alcohol is a highly controversial subjective construct and may be clarified by Loewenstein's visceral theory, which emphasizes craving's behavioral effects on the relative value of alcohol.

Based on the visceral theory, this study examined the effects of a craving induction on the relative value of alcohol as measured by a behavioral choice task. In addition, based on previous evidence of its role in the expression of craving, the influence of DRD4 VNTR genotype (DRD4-L vs. DRD4-S) was also examined.

Factorial analysis of the craving induction revealed that it was associated with significant increase in craving (p < .001), but not greater relative value of alcohol. Factorial analyses including DRD4 VNTR genotype of did not suggest an influence on reactivity to the craving induction, although this analysis was substantially compromised by small cell sample sizes.

Continuous analyses revealed that craving was significantly associated with the relative value of alcohol (p < .05) and possession of the DRD4-L allele further amplified this relationship (p < .001).

These results are interpreted as generally supporting Loewenstein's visceral theory of craving and evidence of a functional role of DRD4 VNTR genotype in the expression of craving for alcohol.

Methodological limitations, mechanisms underlying these findings, and future directions are discussed.

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EEG Biofeedback as a Treatment for Substance Use Disorders: Review, Rating of Efficacy, and Recommendations for Further Research

Appl Psychophysiol Biofeedback. 2008 March; 33(1): 1–28.


Electroencephalographic (EEG) biofeedback has been employed in substance use disorder (SUD) over the last three decades. The SUD is a complex series of disorders with frequent comorbidities and EEG abnormalities of several types. EEG biofeedback has been employed in conjunction with other therapies and may be useful in enhancing certain outcomes of therapy.

Based on published clinical studies and employing efficacy criteria adapted by the Association for Applied Psychophysiology and Biofeedback and the International Society for Neurofeedback and Research, alpha theta training—either alone for alcoholism or in combination with beta training for stimulant and mixed substance abuse and combined with residential treatment programs, is probably efficacious.

Considerations of further research design taking these factors into account are discussed and descriptions of contemporary research are given.

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[Commentary] ALCOHOL AND FRONTAL LOBE IMPAIRMENT: FASCINATING FINDINGS
Addiction Volume 103 Issue 5 Page 736-737, May 2008

What Uekermann and Daum have done in their excellent paper is to specify in more detail the ways in which frontal lobe dysfunction affects social cognition. For example, they have reviewed evidence that alcoholics take longer to decode emotional facial expressions than healthy comparison groups. Not only that, but alcoholics over-estimate the intensity of emotions, and they show a clear bias towards mislabelling sad expressions as hostile. They tend to judge a happy face as reflecting a negative mood state, and fear responses are enhanced. There is some evidence that the decoding of facial expressions improves following abstinence in parallel with improvements in cognitive function, but this is not always seen. Somewhat similarly, alcoholic patients show deficits in identifying the affective component of speech prosody. The association between such impairments and interpersonal problems may predispose to relapse.

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Social cognition in alcoholism: a link to prefrontal cortex dysfunction?
Addiction Volume 103 Issue 5 Page 726-735, May 2008

Alcoholism is associated with a range of cognitive deficits. These deficits might be explained by the ‘frontal lobe hypothesis’ which suggests a specific vulnerability of the prefrontal cortex (PFC) to the neurotoxic effects of alcohol. Social cognition is thought to be processed in the PFC, but so far only few studies have addressed the issue of social cognition deficits in alcoholism.

This review aims to evaluate the deficits in social cognition in alcoholic patients. In addition an outline for future perspectives is given.

Alcoholism is associated clearly with social cognition impairments which include emotional face and prosody perception problems, theory of mind deficits and humour processing difficulties.

In summary, the social cognition impairments are consistent with the frontal lobe hypothesis of alcoholism. Future studies should focus on (i) the delineation of the basic cognitive processes which underlie social cognition deficits; and (ii) their relevance as predictors of treatment outcome in alcoholism.


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Request Reprint E-Mail: jennifer.uekermann@ruhr-uni-bochum.de
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The Australia 2020 Summit - The Record

The Australia 2020 Summit Initial Report was made available to participants after the final session on Sunday April 20. This Report was presented to the Prime Minister, the Honourable Kevin Rudd MP by Professor Glyn Davis AC on behalf of all the participants.

Logistics in getting the Initial Report prepared and printed didn’t allow for the capturing of some of the ideas from the final Sunday sessions.

These Power Point slides from each of the 10 streams summarise the Ambitions and Goals, Priority Themes and Top Ideas.

A more detailed record of the Summit will be available during next month. This record will include:

  • A more formal and detailed record of all the discussion sessions, picking up on the range of ideas put forward;
  • Overviews of the preliminary Summit events, including the Youth Summit, local summits and schools summit;
  • A strategic overview of the ideas raised in the public submission.

The Prime Minister announced that he would like to continue the “national conversation” through the Australia 2020 website.

The submissions database on this site has been disabled. The current capacity of the website will be upgraded to continue to receive submissions and ideas.

The new site to replace this current site, will be available by 7 May 2008.

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Australia 2020 Summit - Initial Report

The Initial Report from the 2020 Summit to the Prime Minister, sets out the key results of discussion by 1000 Australians over the weekend of 19 and 20 April in Canberra.

The Report includes results across the 10 streams of the Summit, including ambitions, priority themes and top ideas from each stream.

A more detailed, final report of the Summit to the Prime Minister will be prepared next month and will be available on the web site.

Stream - A Long-term National Health Strategy

  • Create a national preventative health agency. This independent health body would be funded by taxes on products with high social cost, e.g. alcohol, cigarettes and junk food (like a national version of VicHealth). The body would commission research, design interventions based on evidence, develop and deliver preventative health policy, and implement marketing and public health campaigns.

Download Australia 2020 Summit - Initial Report - WORD 2.6MB | PDF 1MB


Conference conclusions - European Alcohol Policy Conference

The third European Alcohol Policy conference, Building Capacity for Action, took place in Barcelona, 3rd-5th April 2008, with 352 participants from 36 countries. The conference, which was encompassed within the programme of activities organized by the Slovenian Presidency of the Council of European Union, was supported by the Ministry of Health and Consumer Affairs of Spain and the Ministry of Health of Slovenia, and was hosted by the Regional Government of Catalonia. The conference was co-financed by the European Commission, and co-sponsored by the Regional Office for Europe of the World Health Organization and the European Alcohol Policy Alliance.

Conference Conclusions

  • Alcohol causes a high level of harm
  • Young people are vulnerable to alcohol
  • Alcohol causes harm to people other than the drinker
  • Government regulation needs to be strengthened
  • Help needs to be available for people with problems
  • Focusing on their product, economic operators have the potential to reduce harm
  • Raising the voice of civil society
  • Capacity for Action
  • Towards a Global Strategy
  • Expanding the evidence base

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Effectiveness of the AUDIT-C as a Screening Test for Alcohol Misuse in Three Race/Ethnic Group
J Gen Intern Med, Online first 18 April 2008



The Alcohol Use Disorders Identification Test—Consumption (AUDIT-C) is a brief validated screen for risky drinking and alcohol abuse and dependence (alcohol misuse). However, the AUDIT-C was validated in predominantly White populations, and its performance in different racial/ethnic groups is unclear.

Race/ethnicity was self-reported. Areas under the receiver operating curve (AuROCs) evaluated overall AUDIT-C performance in the 3 racial/ethnic groups compared to diagnostic interviews for alcohol misuse. AUDIT-C sensitivities and specificities at recommended screening thresholds were compared across racial/ethnic groups. AuROCs were greater than 0.85 in all 3 groups, with no significant differences across racial/ ethnic groups in men (P=.43) or women (P=.12). At previously recommended cut points, there were statistically significant differences by race in AUDIT-C sensitivities but not specificities. In women, the sensitivity was higher in Hispanic (85%) than in African-American (67%; P=.03) or White (70%; P=.04) women. In men, the sensitivity was higher inWhite (95%) than in African-Americanmen (76%; P=.01), with no significant difference from Hispanic men (85%; P=.11).

The overall performance of the AUDITC was excellent in all 3 racial/ethnic groups as reflected by high AuROCs. At recommended cut points, there weresignificant differences in the AUDIT-C’s sensitivity but not in specificity across the 3 racial/ethnic groups.

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Sunday, April 20, 2008

Ministry says alcohol poses a threat to Finnish internal security
16 April 2008

Action programme urges heavier taxation and reduction in consumption to 2003 levels

Finnish drinking habits pose a considerable threat to the security of the nation.

This is the view of the Ministry of the Interior, which on Tuesday published a broad-based action programme to improve internal security in the country.

Security is being eroded by such things as marginalisation, accidents, and violence. Alcohol is seen as the most common reason for violence and the cause of countless accidents. “Finland is paying a stiff price for its alcohol culture”, says the ministry’s Permanent Secretary
Ritva Viljanen.
. . . . . .

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Alcohol and Drug Use Among European 17-18 Year Old Students

The three large ESPAD (The European School Survey Project on Alcohol and Other Drugs) surveys that were conducted in 1995, 1999 and 2003 investigated the use of alcohol and other drugs among students aged 15–16 (Hibell, Andersson et al 1997, Hibell, Andersson et al 2000, Hibell, Andersson et al 2004). Over the years an increasing number of countries have joined the
project and in the last survey 35 European countries collaborated on data collections on nationally representative samples.

The number of countries included in this study is limited but represent different parts of Europe. On many variables France and Sweden appear as opposite poles regarding alcohol consumption and drug use. The French students drink little and seldom get drunk, while the prevalence of cannabis consumption is high. In Sweden, on the other hand, drunkenness is frequent, but the prevalence of illicit drug use, mainly cannabis, is the lowest among the countries included in this study.

Overall, the results indicate that the tobacco, alcohol and drug use pattern among students aged 17–18 varies a great deal between the seven countries included in this study. For example, almost half of the students are more or less habitual smokers, except in Sweden where this is truefo r about one third.

Rather few – one fifth or less – had been drinking alcohol 10 times or more during the past 30 days, especially in Sweden. Drunkenness, on the other hand, is much more frequent among the Swedish students in comparison, but especially in relation to the Mediterranean countries, which are very low on this variable.

It is difficult to draw any conclusions from the pattern of alcohol consumption and drunkenness. It seems as if the Swedish students were more inclined to declare a high frequency of intoxication than students in other countries, despite the fact that they drink less often. The binge drinking frequency, however, is a little bit higher among the Swedes than among students in the other countries, but still not far from average.

The lifetime prevalence of illicit drug use, however, gives a picture rather opposite to the alcohol variables. France, which is generally low on most alcohol variables, is dominating the picture with 6 out of 10 students reporting use of cannabis. Italy is the country that comes closest to this, but is still lower (4 out of 10). In contrast, the use of illicit drugs other than cannabis is generally much lower in all the countries under study.

To analyse why some students refrain from alcohol and/or alcohol intoxication, but consume illicit drugs such as cannabis would be an important contribution to the understanding of the formation of drug habits among people this age.

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