A gene x gene interaction between DRD2 and DRD4 is associated with conduct disorder and antisocial behavior in males Behavioral and Brain Functions 2007, 3:30
Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene X gene interactions in the etiology of conduct disorder and antisocial behavior.
| Published | 22 June 2007 |
Antisocial behaviors are complex polygenic phenotypes that are due to a multifactorial arrangement of genetic polymorphisms. Little empirical research, however, has been undertaken that examines gene X gene interactions in the etiology of conduct disorder and antisocial behavior.
This study examined whether adolescent conduct disorder and adult antisocial behavior were related to the dopamine D2 receptor polymorphism (DRD2) and the dopamine D4 receptor polymorphism (DRD4).
Multivariate regression analysis revealed that neither DRD2 nor DRD4 had significant independent effects on conduct disorder or antisocial behavior. However, DRD2 interacted with DRD4 to predict variation in adolescent conduct disorder and in adult antisocial behavior.
The results suggest that a gene X gene interaction between DRD2 and DRD4 is associated with the development of conduct disorder and adult antisocial behavior in males.
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