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Saturday, June 9, 2007

Effect of ADH1B Genotype on Alcohol Consumption in Young Israeli Jews
Alcoholism: Clinical and Experimental Research (OnlineEarly Articles). 9 June 2007


The alcohol dehydrogenase 1B (ADH1B) genotype affects the risk for alcoholism, with elevated prevalence of a protective allele in Jews. Alcohol consumption is increasing among younger Israeli Jews, reflecting environmental influences.

We investigated whether the relationship of ADH1B genotype with alcohol consumption differed between younger and older adult Israelis.

Maximum lifetime drinking among younger adult Israelis without genetic protection exceeded thresholds for risky and unsafe drinking (≥5 drinks).

Environmental influences promoting greater drinking among younger Israelis may particularly affect those with the nonprotective, more common ADH1B genotype.

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