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Monday, June 18, 2007

Apolipoprotein E gene polymorphism and previous alcohol withdrawal seizures
Journal of Psychiatric Research
Volume 41, Issue 10, November 2007, Pages 871-875




Aim of this study was to investigate the possible association of apolipoprotein E (ApoE) gene polymorphism with a history of alcohol withdrawal seizures.

A significant positive association with a positive history of withdrawal seizures (SZ+) was found in the ApoE3 allele group (Fisher’s exact test: p = 0.006) while a significant negative association was observed in the ApoE2 allele group (Fisher’s exact test: p = 0.029).

For the ApoE4 allele group no significant differences were found regarding a history of withdrawal seizures.

Our findings suggest an association between the apolipoprotein E3 gene variant and an elevated risk of alcohol withdrawal seizures. These preliminary results must be validated in further studies.

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Reprint Request E-Mail: julia.wilhelm@psych.imed.uni-erlangen.de
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