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Wednesday, May 16, 2007

Markers in the 5'-Region of GABRG1 Associate to Alcohol Dependence and are in Linkage Disequilibrium with Markers in the Adjacent GABRA2 Gene
Neuropsychopharmacology advance online publication 16 May 2007;





Following an initial report, there have been multiple replications of an association of alcohol dependence (AD) to markers within a haplotype block that includes the 3'-half of the gene encoding the GABAA alpha-2 subunit (GABRA2), on chromosome 4p.

We examined the intergenic extent of this haplotype block and the association to AD of markers in the adjacent 5' haplotype block in GABRG1, which encodes the GABAA receptor italic gamma-1 subunit.

Logistic regression analysis indicated that genetic elements in the GABRG1 haplotype block likely contribute to AD risk in an additive manner, whereas those in the GABRA2 haplotype block may act in a dominant manner in relation to risk of AD.

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Reprint Request E-mail: jocovault@uchc.edu
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