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Monday, May 14, 2007

Glutamate signaling proteins and tyrosine hydroxylase in the locus coeruleus of alcoholics
Journal of Psychiatric Research Article in Press,
3 May 2007



It has been postulated that alcoholism is associated with abnormalities in glutamatergic neurotransmission.

This study examined the density of glutamate NMDA receptor subunits and its associated proteins in the noradrenergic locus coeruleus (LC) in deceased alcoholic subjects.

Lower levels of NR1 subunit of the NMDA receptor in the LC implicates altered glutamate–norepinephrine interactions in alcoholism.

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