Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

___________________________________________

Thursday, May 17, 2007

5′ UTR polymorphism of dopamine receptor D1 (DRD1) associated with severity and temperament of alcoholism
Biochemical and Biophysical Research Communications
Volume 357, Issue 4, 15 June 2007, Pages 1135-1141



Multiple dopamine receptors in the dopaminergic system may be prime candidates for genetic influence on alcohol abuse and dependence due to their involvement in reward and reinforcing mechanisms.

To examine the genetic effects of the Dopamine Receptor D1 (DRD) gene family (DRD1–DRD5) in the Korean population, 11 polymorphisms in the DRD gene family were genotyped and analyzed in 535 alcohol-dependent subjects and 273 population controls.

One 5′ UTR polymorphism in the DRD1 (DRD1−48A>G) gene was significantly associated with severity of alcohol-related problem.

Interestingly, the DRD1−48A>A genotype was also found to be associated with novelty seeking (NC), harm avoidance (HA), and persistence.

The information derived from this study could be valuable for understanding the genetic factors involved in alcoholic phenotypes and genetic distribution of the DRD gene family, and could facilitate further investigation in other ethnic groups.

Read Full Abstract

Reprint Request E-mail: hdshin@snp-genetics.com
_________________________________________________
at