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Saturday, September 12, 2009

Roles of the Genetic Polymorphisms of Alcohol-Metabolizing Enzymes on the Immunology in High-Risk Drinkers
Toxicological Sciences 2009 111(2):267-276

Alcohol metabolism involves several enzymes and the individual genetic variations in the alcohol metabolism are related to the absorption, distribution, and elimination of alcohol and metabolites such as acetaldehyde. Therefore, the genetic variations of alcohol-metabolizing enzymes are responsible for the different toxicity of alcohol in several organs like liver and immunological systems.

The purpose of this study was to evaluate if the life styles such as drinking and smoking and the genetic variations of alcohol-metabolizing enzymes (ADH2, ALDH2, CYP2E1, and CAT) were associated with the immunological biomarkers.

Our results suggested that the habits of drinking, smoking, and betel chewing, and genetic variations of alcohol metabolism were associated with the immunological biomarkers.


Request Reprint E-Mail: tsliyu@kmu.edu.tw

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