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Monday, September 7, 2009


Bioavailability of Gallic Acid and Catechins from Grape Seed Polyphenol Extract is Improved by Repeated Dosing in Rats: Implications for Treatment in Alzheimer's Disease
Journal of Alzheimer's Disease Volume 18, Number 1 / 2009 pp, 113-124

The present study explored the bioavailability and brain deposition of a grape seed polyphenolic extract (GSPE) previously found to attenuate cognitive deterioration in a mouse model of Alzheimer's disease (AD).

Repeated daily exposure to GSPE was found to significantly increase bioavailability (defined as plasma AUC_{0-8h}) of GA, C, and EC by 198, 253, and 282% relative to animals receiving only a single acute GSPE dose. EC and C were not detectable in brain tissues of rats receiving a single GSPE dose but reached levels of 290.7 ± 45.9 and 576.7 ± 227.7 pg/g in brain tissues from rats administered GSPE for 10 days.

This study suggests that brain deposition of GA, C, and EC is affected by repeated dosing of GSPE.

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Request Reprint E-Mail: mferruzz@purdue.edu

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