Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study
World J Gastroenterol 2008 April;14(14):2255-2261

To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of China.

Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done.

Daily alcohol intake >= 20 g, duration of drinking >= 5 years and obesity were closely related to alcohol-related liver injury (P <>= 20 g daily alcohol intake group and <>= 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively.

No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking group.

The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned.


Read Full Abstract


Request Reprint E-Mail: zlym@zju.edu.cn
____________________________________________________________________