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Monday, March 26, 2007

The Alcohol-Induced Suppression of Ovarian Insulin-Like Growth Factor-1 Gene Transcription Is Independent of Growth Hormone and Its Receptor

Insulin-like growth factor-1 (IGF-1) plays an important role in ovarian development and function.

Alcohol (ALC) is a gonadal toxin and capable of causing depressed ovarian IGF-1 and suppressed estradiol. The mechanism by which ALC affects IGF-1 transcription is not well understood, and more information is needed to better understand the interrelationships between ALC, growth hormone (GH) and its ovarian receptor, and the gene expression of ovarian IGF-1.

These results suggest that the ALC-induced suppression of ovarian IGF-1 gene transcription is independent of alterations in serum GH.

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