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Friday, October 24, 2008
Oxidative stress disturbs energy metabolism of mitochondria in ethanol-induced gastric mucosa injury World J Gastroenterol 2008 October;14(38):5857-5867
To study the role of mitochondrial energy disorder in the pathogenesis of ethanol-induced gastric mucosa injury.
The gastric mucosal lesion index was correlated with the MDA content in gastric mucosa. As the concentration of ethanol was elevated and the exposure time to ethanol was extended, the content of MDA in gastric mucosa increased and the extent of damage aggravated. The ultrastructure of mitochondria was positively related to the ethanol concentration and exposure time. The expression of mtDNA ATPase subunits 6 and 8 mRNA declined with the increasing MDA content in gastric mucosa after gavage with ethanol.
Ethanol-induced gastric mucosa injury is related to oxidative stress, which disturbs energy metabolism of mitochondria and plays a critical role in the pathogenesis of ethanol-induced gastric mucosa injury.