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Thursday, October 23, 2008

Identification of Novel Bone-Specific Molecular Targets of Binge Alcohol and Ibandronate by Transcriptome Analysis
Alcoholism: Clinical and Experimental Research Volume 32 Issue 7, Pages 1167 - 1180

Our laboratory established that binge alcohol-related bone damage is prevented by aminobisphosphonates, suggesting bone resorption increases following binge exposure.

We examined the effects of binge alcohol and antiresorptive therapy on the relationship between bone damage and modulation of the vertebral transcriptome, in an attempt to determine how alcohol-induced bone damage and its prevention modulate bone-related biological pathways.

Bone loss was not observed after 1 week of binge alcohol treatment. After 4 weeks, binge alcohol decreased vertebral BMD by 23% (p < class="i">p < class="i">p < class="h5-inline">

Identification of bone-specific gene expression clusters associated with acute and chronic binge alcohol treatment allowed for the identification of cellular pathways affected by binge treatment with known involvement in bone remodeling (Integrin, Canonical Wnt signaling) not previously identified as alcohol-sensitive.

This data provides a basis for a plausible mechanistic explanation for the known detrimental effects of alcohol on bone formation and resorption.

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Request Reprint E-Mail: jcallaci@lumc.edu

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