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Friday, October 24, 2008

Lack of association of the serotonin transporter gene promoter region polymorphism, 5-HTTLPR, including rs25531 with cigarette smoking and alcohol consumption
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Publihed Online 24 October 2008

We addressed the question whether 5-HTTLPR, a variable number of tandem repeats located in the 5 end of the serotonin transporter gene, is associated with smoking or alcohol consumption.

Samples of DNA from 1,365 elderly women with a mean age of 69.2 years were genotyped for this polymorphism using a procedure, which allowed the simultaneous determination of variation in the number of repeat units and single nucleotide changes, including the A > G variation at rs25531 for discrimination between the LA and LG alleles. Qualitative and quantitative information on the women's current and previous consumption of cigarettes and alcohol were obtained using a questionnaire. Genotypes were classified according to allele size, that is, S and L with 14 and 16 repeat units, respectively, and on a functional basis by amalgamation of the LG and S alleles. Data were subjected to regression analyses.

These analyses revealed P values for associations between 5-HTTLPR genotype and alcohol and cigarette consumption in the range from 0.15 to 0.92. On adjustment for age and educational level, significance for the associations of 5-HTTLPR with the smoking and alcohol consumption measures was not reached.

We conclude that 5-HTTLPR is not an important determinant of smoking behavior and alcohol consumption in elderly women.

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