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Monday, October 20, 2008

The Association Between Alcohol Consumption and Risk of COPD Exacerbation in a Veteran Population
. 2008; 134:761-767

Alcohol has been associated with COPD-related mortality but has not yet been demonstrated to be an independent risk factor for COPD exacerbation. Our objective was to evaluate the association between alcohol consumption and the subsequent risk of COPD exacerbation.

Among the 30,503 patients followed up for a median of 3.35 years, those patients with AUDIT-C scores ≥ 6, CAGE scores ≥ 2, or who reported binge drinking at least weekly were at an increased risk of COPD exacerbation in age-adjusted analysis. Adjusted hazard ratios were 1.4 (95% confidence interval [CI], 1.1 to 1.7) for AUDIT-C score ≥ 6, 1.4 (95% CI, 1.3 to 1.5) for CAGE score ≥ 2, and 1.6 (95% CI, 1.2 to 2.2) for those who reported binge drinking daily or almost daily. However, with adjustment for measures of tobacco use, the association between alcohol consumption and increased risk of COPD exacerbation was no longer evident.

Alcohol consumption, whether quantified by AUDIT-C, CAGE score, or binge drinking, was not associated with an increased risk of COPD exacerbation independent of tobacco use.

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