Effect of gestational ethanol exposure on long-term memory formation in newborn chicks
Alcohol Article in Press, Corrected Proof -12 July 2007




Fetal alcohol syndrome (FAS), a condition occurring in some children of mothers who have consumed alcohol during pregnancy, is characterized by craniofacial malformations, and physical and mental retardation. It is significant that even children with history of gestational ethanol exposure but relatively unaffected overall IQ performance, often exhibit learning difficulties and behavioral problems, suggestive of impaired memory formation.

It was observed that chick embryos exposed to 10% ethanol on gestational days 1–3 had significant reduction in all body parameters when compared with appropriate controls. Further, ethanol-exposed chick embryos had significantly impaired (P < .05) long-term memory (LTM) formation after training, though short-term or intermediate-term memory formation was unimpaired.

Thus, the findings of the current study demonstrate the detrimental effects of ethanol exposure during early pregnancy on developing chick embryos in general and on memory formation in particular.

Hence, it is suggested that impairment in LTM could be a fundamental mechanism for learning disorders and neurobehavioral abnormalities observed in FAS.


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Reprint Request E-Mail: jchaud@midwestern.edu
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