Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivityAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Early View 24 May 2007
Impulsivity, a highly prevalent symptom in multiple psychiatric disorders, is a partially heritable trait influenced by specific biological mechanisms.
In particular, dopamine is proposed to play a role in impulsive behaviors and recent studies have implicated functional polymorphisms of dopamine-related genes in impulsive behaviors across different clinical and behavioral classifications.
However, most have not isolated the impulsivity construct per se as a biologically based and measurable endophenotype.
The present study was therefore undertaken in a sample of healthy adults to investigate the influence of two candidate dopaminergic gene polymorphisms (DRD4 and DAT) on the endophenotype of impulsivity.
Results of the present study support the influence of dopaminergic variation on impulsive-related measures, as well as the advantage of using measures which are likely more sensitive to the effects of such genetic variation.
Read Full Abstract
Reprint Request E-mail: econgdon@ic.sunysb.edu
_____________________________________________________________
Early View 24 May 2007
Impulsivity, a highly prevalent symptom in multiple psychiatric disorders, is a partially heritable trait influenced by specific biological mechanisms.
In particular, dopamine is proposed to play a role in impulsive behaviors and recent studies have implicated functional polymorphisms of dopamine-related genes in impulsive behaviors across different clinical and behavioral classifications.
However, most have not isolated the impulsivity construct per se as a biologically based and measurable endophenotype.
The present study was therefore undertaken in a sample of healthy adults to investigate the influence of two candidate dopaminergic gene polymorphisms (DRD4 and DAT) on the endophenotype of impulsivity.
Results of the present study support the influence of dopaminergic variation on impulsive-related measures, as well as the advantage of using measures which are likely more sensitive to the effects of such genetic variation.
Read Full Abstract
Reprint Request E-mail: econgdon@ic.sunysb.edu
_____________________________________________________________
