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Monday, October 26, 2009

Ethanol Upregulates iNOS Expression in Colon Through Activation of Nuclear Factor-kappa B in Rats
Alcoholism: Clinical and Experimental Research Early View 23 Oct 2009

Alcohol inhibits colonic motility but the mechanism is unknown. The goal of this study was to test the possibility that nuclear factor-kappa B (NF-κB) is involved in the upregulation of inducible nitric oxide synthase (iNOS) expression induced by ethanol in colon.

Ethanol inhibited the contraction of LP in colon mainly through activation of NF-κB, the subsequent upregulation of iNOS expression and increase of NO release in myenteric plexus.


Request Reprint E-Mail: liucy@sdu.edu.cn

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