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Sunday, April 27, 2008

Interleukin-10 Gene Polymorphism is Associated with Alcoholism but not With Alcoholic Liver Disease
Alcohol and Alcoholism Advance Access published online on April 24, 2008


To determine whether the functional polymorphism –592C>A of the interleukin (IL)-10 gene (IL10) influences the development of alcoholic liver disease or alcoholism in alcoholic Spanish subjects.

We found no association between the –592C>A IL10 polymorphism and ALC. Meta-analysis combining this result and data from previous studies failed also to show any significant association between this polymorphism and alcoholic liver disease. However, the frequency of allele A carriers (CA and AA genotypes) was significantly higher in alcoholic patients (defined as patients with abuse or dependence of alcohol) than in healthy controls.

The –592C>A IL10 polymorphism is not related to the risk of ALC. Nevertheless, our study shows that alcoholism is associated with an excess of allele A carriers in alcoholic patients.

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