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Saturday, May 5, 2007

Monoamine oxidase-A polymorphisms might modify the association between thedopamine D2 receptor gene and alcohol dependence
J Psychiatry Neurosci 2007;32(3):185-92.

Low monoamine oxidase (MAO) activity and the neurotransmitter dopamine are two important factors in the development of alcohol dependence. MAO is an important enzyme associated with the metabolism of biogenic amines.

Therefore, the present study investigates whether the association between the dopamine D2 receptor (DRD2) gene and alcoholism is affected by different polymorphisms of the MAO type A (MAOA) gene.

The MAOA gene may modify the association between the DRD2 gene and ANX/DEP ALC phenotype.

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