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To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Sunday, May 31, 2009

Alcohol consumption and decreased risk of non-Hodgkin lymphoma: role of mTOR dysfunction
Blood, 28 May 2009, Vol. 113, No. 22, pp. 5526-5535.

Our data support a paradigm in which chronic ethanol exposure inhibits mTOR signaling in lymphocytes with a significant repression of cap-dependent translation, reducing the tumorigenic capacity of non-Hodgkin lymphoma in a human xenograft model. The ethanol-mediated repression of mTOR signaling coupled with decreased in vivo lymphoma growth underscore the critical role of mTOR signaling and translation in lymphoma.




Request Reprint E-Mail: rgartenhaus@som.umaryland.edu

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