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Wednesday, April 23, 2008

Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
Pharmacology Biochemistry and Behavior Volume 89, Issue 4, June 2008, Pages 481-498



The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats.

For the ACB, there were 513 significant differences at the p <>p <>p <>Cav2, Nrxn3, Gabrb2, Gad1, Homer1) and homeostasis (S100b, Prkca, Ftl1) categories.

Overall, the results suggest that changes in gene expression in the ACB of iP rats are associated with the reinforcing effects of EtOH.

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