Moderate alcohol consumption and lipoprotein-associated phospholipase A2 activityNutrition, Metabolism and Cardiovascular Diseases Article in Press, 3 Dec 200
To investigate the effect of moderate alcohol consumption on lipoprotein-associated phospholipase A2 activity, markers of inflammation and oxidative stress and whether these effects are modified by BMI.
Eleven lean (BMI: 18.5–25 kg/m2) and 9 overweight (BMI > 27 kg/m2) men participated in a randomized controlled crossover trial. After consuming 3 cans of beer (40 g ethanol) or alcohol-free beer daily during 3 weeks, fasting blood samples were taken.
HDL cholesterol increased by 18.2% . Lipoprotein-associated phospholipase A2 activity was not different between beer (47.5 ± 0.8) and alcohol-free beer (48.9 ± 0.8). High-sensitive C-reactive protein was unaffected, but urinary isoprostanes tended to increase after beer (114.0 ± 6.9) compared to alcohol-free beer (96.9 ± 6.5).
An interaction between BMI and treatment on liver enzymes was observed, indicating an increase of liver enzymes after moderate alcohol consumption in overweight men only.
Despite profound effects on HDL and LDL cholesterol, moderate alcohol consumption did not affect lipoprotein-associated phospholipase A2 activity. Liver enzymes increased after alcohol consumption in overweight men only, suggesting a less favorable response to moderate alcohol consumption in overweight people.
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