Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Thursday, March 22, 2007

Psychiatric Comorbidity in Long-Term Abstinent Alcoholic Individuals
Alcoholism: Clinical and Experimental Research (OnlineEarly Articles).
22 March 2007


A high prevalence of comorbid psychiatric disorders has been demonstrated in individuals with an alcohol use disorder in both community and treatment samples, with higher comorbidity in treatment samples.

In this study, we examined lifetime and current psychiatric diagnoses in long-term abstinent alcoholic individuals (LTAA; mean abstinence=6.3 years; n=52) compared with age and gender-comparable non-alcoholic controls (NC; n=48).

We asked the following questions: (1) to achieve long-term abstinence, must an individual be relatively psychiatrically healthy (i.e., comparable with NC) and (2) can ongoing abstinence be maintained in the face of a current psychiatric disorder?

Over 85% of LTAA had a lifetime psychiatric diagnosis, compared with 50% of NC. Long-term abstinent alcoholic individuals had a higher prevalence than NC of lifetime mood, anxiety, and externalizing disorder diagnoses. Long-term abstinent alcoholic individuals also had a greater prevalence than NC of current mood and anxiety diagnoses.

Although LTAA had a greater lifetime prevalence of an antisocial personality disorder (ASPD) than NC, no LTAA or NC had a current ASPD diagnosis.

Finally, there was no association of duration of abstinence with lifetime or current psychiatric diagnoses, consistent with psychiatric diagnoses having little effect on relapse.

Our results suggest that: (1) the presence of a lifetime psychiatric diagnosis does not militate against achieving long-term abstinence, (2) abstinence can be maintained in the presence of a current mood or anxiety disorder, and (3) a current diagnosis of ASPD may not be compatible with long-term abstinence.

The relatively low levels of antisocial behavior compared with preabstinence (as indicated by no LTAA meeting current criteria for ASPD) raises the question of whether the neurobiology underlying antisocial behavior is changed in abstinence, or brought under increased executive control, or both.

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Spousal Concordance for Alcohol Dependence: Evidence for Assortative Mating or Spousal Interaction Effects?

Alcoholism: Clinical and Experimental Research (OnlineEarly Articles).
22 March 2007


  • 1Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri; and 2Queensland Institute of Medical Research, Brisbane, Australia

Sources of support: AA11998, AA07535, AA00728, AA10249.

Reprint requests: Julia D. Grant, PhD, Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St. Louis, MO 63110; Fax: 314 286 2243; E-mail: grantj@msnotes.wustl.edu

Abstract

Background:

Alcohol dependence (AD) is among the most common psychiatric disorders, and impacts the health and well-being of problem drinkers, their family members, and society as a whole.

Although previous research has consistently indicated that genetic factors contribute to variance in risk for AD, little attention has been paid to nonrandom mating for AD. When assortative mating occurs for a heritable trait, spouses are genetically correlated and offspring are at increased risk of receiving high-risk genes from both parents.

The primary goal of the present analyses is to test hypotheses about the source(s) and magnitude of spousal associations for AD using a twin-spouse design.

Methods:

DSM-IV AD (without the clustering criterion) was assessed via telephone interview for 5,974 twin members of an older cohort of the Australian Twin Register (born 1902–1964) and 3,814 spouses of the twins.

Quantitative genetic modeling was used to determine the extent to which variability in risk for AD was influenced by genetic factors, the extent of spousal association for AD, and whether the association was attributable to assortative mating, reciprocal spousal interaction, or both processes.

Results:

Genetic factors explained 49% of the variance in risk for AD.

There was no evidence of gender differences in the spousal interaction effect, the degree of rater bias, or the association between the twin's report of spouse AD and the spouse's AD phenotype.

Either the assortative mating parameter or the spousal interaction parameter could be removed from the model without a significant decrement in fit, but both could not be dropped simultaneously, suggesting a lack of power to differentiate between these 2 causes of spousal correlation.

When both effects were included in the model, the spousal correlation was 0.29, the assortative mating coefficient was 0.45 (i.e., "like marries like"), and the reciprocal spousal interaction coefficient was −0.10 (i.e., after controlling for assortative mating, the additional impact of spousal interactions is slightly protective).

Conclusions:

These analyses provide evidence of significant spousal associations for AD, with assortative mating increasing spouse similarity and spousal interaction effects decreasing it after controlling for assortative mating.

Although the genetic impact is modest, assortative mating results in an increased proportion of offspring exposed to 2 alcoholic parents and the associated detrimental environmental sequelae, and increases the likelihood of offspring inheriting high-risk genes from both parents.
Ethanol-Associated Cues Produce General Pavlovian-Instrumental Transfer

Alcoholism: Clinical and Experimental Research (OnlineEarly Articles).
22 March 2007


  • 1Department of Neurology, Ernest Gallo Clinic and Research Center, University of California, San Francisco, California

The research reported in this paper was supported by funds from the state of California for medical research on alcohol and substance abuse through the University of California, San Francisco.

Reprint requests: Laura H. Corbit, PhD, Department of Neurology, Ernest Gallo Clinic and Research Center, 5858 Horton St. Suite 200, Emeryville, CA 94608; Fax: 510-985-3101; E-mail: lcorbit@gallo.ucsf.edu

Abstract

Background:

Conditioned stimuli are thought to play an important role in maintaining ethanol use and inducing relapse. Therefore, understanding the mechanisms through which such stimuli trigger ethanol seeking is of interest in the study and treatment of alcoholism.

Methods:

This series of experiments examined the impact of ethanol-associated cues on ethanol-seeking behavior using a Pavlovian-instrumental transfer design. Rats received Pavlovian training in which an auditory stimulus predicted ethanol (10%) delivery. In a separate instrumental training phase, animals were trained to press a lever for ethanol. In the test phase, the impact of the stimulus on instrumental performance was assessed in extinction by presenting the stimulus while animals were free to perform the lever-press response. Experiment 2 assessed the selectivity of the transfer effect; rats received training with 2 auditory stimuli which predicted either ethanol or sucrose (2%) delivery and were trained to perform 2 instrumental responses, one earning ethanol and the other earning sucrose. Finally, Experiment 3 examined the selectivity of PIT using 2 natural rewards (sucrose and polycose).

Results:

The results from Experiment 1 show that ethanol supports excitatory conditioning and that ethanol-associated cues facilitate instrumental performance for ethanol. When the selectivity of the transfer effect was examined in Experiment 2, the ethanol-paired stimulus was found to have a general excitatory effect on reward-seeking behavior, affecting both ethanol-directed and sucrose-directed responding equally. In contrast, the sucrose-paired stimulus had a selective effect, elevating sucrose-directed responding only. Experiment 3 confirms that selective transfer is observed when 2 natural rewards are used to reinforce responding.

Conclusions:

These data provide further evidence that ethanol-associated cues can drive ethanol-seeking behaviors. Because ethanol-associated cues also enhanced seeking behavior for a nonalcohol reward, these results additionally suggest that the modulation of reward-directed behaviors by cues associated with ethanol versus natural rewards may rely on different behavioral and neural mechanisms.
Morphometry of Dorsal Raphe Nucleus Serotonergic Neurons in Alcoholism

Alcoholism: Clinical and Experimental Research (OnlineEarly Articles).
22 March 2007



  • 1Department of Neuroscience, New York State Psychiatric Institute, New York, New York; and 2Department of Psychiatry, College of Physicians & Surgeons of Columbia University, New York, New York.

This work was supported by AA11293, AA09004, MH40210, MH46745, and MH47097.

Reprint requests: Mark Underwood, PhD, Department of Neuroscience, New York State Psychiatric Institute, 1051 Riverside Drive Box 42, New York, NY 10032; Fax: 212-543-5998; E-mail: undie@neuron.cpmc.columbia.edu

Abstract

Background:

Reduced serotonergic function is hypothesized in alcohol abuse and dependence. Serotonergic innervation of the cortex arises predominantly from the dorsal raphe nucleus (DRN). We sought to determine the number and morphometric characteristics of DRN serotonergic neurons postmortem in alcoholic individuals (n=9; age: 16–66years; 8M:1F) compared with psychiatrically normal, nonalcoholic controls (n=6; age: 17–74 years; 4M:2F).

Methods:

Brainstems were collected at autopsy, fixed and cryoprotected. Alcohol dependence or abuse was determined by psychological autopsy (DSM-IV), the presence of liver fatty changes or cirrhosis and/or high blood alcohol level. Tissue was sectioned at 50 μm (−25°C). A series of 1:10 sections was immunoreacted with antiserum to tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of serotonin. The total number of TPH-immunoreactive (IR) DRN neurons was determined by stereology. Neuron morphometry indices were determined using a video-based imaging system attached to a microscope. We identified TPH-IR neurons every 1,000 μm in each brainstem and measured neuron area, total cross sectional neuron area, and the total area and density of immunolabeled processes.

Results:

Dorsal raphe nucleus neuron number (controls: 80,386±10,238; alcoholic individuals: 85,884±12,478) was not different between groups but TPH-IR was greater in alcoholic individuals throughout the rostrocaudal extent of the DRN. The volume of the DRN was 66±9 mm3 in controls and 55±5 mm3 in alcoholic individuals (p>0.05). The average size of DRN neurons did not differ between groups (353±12 μm2 for controls vs 360±15 μm2 for alcoholic subjects). However, the area occupied by neuron processes (area of processes/DRN area) was 2.2-fold greater in alcoholic individuals compared with controls (p<0.05).>

Conclusions:

The increased area occupied by neuron processes in alcoholic individuals may represent sprouting and, together with greater TPH-IR, be a compensatory response to impaired serotonergic transmission or cumulative effects of alcohol on the serotonin system.
Trysh Travis finds something to like about HBO's Addiction project





Barbara Koppel’s “Steamfitters Local Union 638” is the most compelling of the nine mini-documentaries that make up HBO’s Addiction. I think I’ve made my skepticism about the multi-platform project’s obsession with addiction as a “scientifically-proven brain disease” clear in previous posts, but let me risk going just a little further over the top by saying that I think that the reason Koppel’s piece is more satisfying as cinema is directly related to its lack of interest in “disease.”

....more

Source: Alcohol and Drugs History Society

Tuesday, March 20, 2007

Does matching matter? Examining matches and mismatches between patient attributes and therapy techniques in alcoholism treatment.

Addiction. 2007 Apr;102(4):587-96





Integrated Substance Abuse Programs, University of California, Los Angeles, CA, USA.

Abstract

Aims

This study assessed the predictive validity of the level of matching and mismatching between patients' personal attributes and aspects of outpatient psychotherapy they received.

Design and participants

On the basis of patient-by-treatment interactions observed for this sample in previous research, patients with alcohol abuse or dependence (n = 137) were designated retrospectively as being matched, unmatched or mismatched on each of four patient and treatment variable pairings. These pairings included (1) patient depressive symptoms and therapy emotion focus, (2) patient trait anger and therapy confrontation, (3) patient interpersonal reactance and therapy confrontation and (4) patient interpersonal reactance and therapy structure.

Measurements

Analyses of variance and logistic regression were used to assess the individual and additive effects of being matched and mismatched on the percentage of abstinent days (PDA) and recovery status in the year after treatment.

Findings

Being mismatched on any of the four patient-treatment pairings was a significant predictor of more frequent alcohol use post-treatment. Being matched on only two pairings predicted less frequent alcohol use, namely matches on therapy emotion focus with patient depressive symptoms and therapy structure with patient reactance.

Matches appeared to optimize otherwise good outcomes, while mismatches had larger effect sizes and tended to predict relatively poor outcomes.

The data supported the presence of an additive effect for mismatches on post-treatment PDA. The group with the most mismatches fared considerably worse than a group with fewer mismatches. Several matches and mismatches also predicted recovery status, with some support found for additive effects.

Conclusions

Mismatches between patient attributes and treatment appear to have serious consequences, and this effect is magnified with multiple mismatches. Matches, on the other hand, while beneficial, may not be necessary to achieve good outcomes.


Press Release - $24M Grant For OHSU-Led Alcohol Research Consortium







March 20, 2007

Contact: Jonathan Modie
503-494-8231
Email Jonathan Modie






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PORTLAND, Ore. - The National Institute on Alcohol Abuse and Alcoholism (NIAAA) has funded a five-year, $24 million Integrative Neuroscience Initiative on Alcoholism grant to support a consortium led by an Oregon Health & Science University researcher.

Of the total grant, OHSU will receive about $6.3 million over five years, funding projects in the laboratories of Kathleen A. Grant, Ph.D., professor of behavioral neuroscience in the OHSU School of Medicine. The consortium, Integrative Neuroscience Initiative on Alcoholism: Stress, Anxiety and Alcoholism, or INIAstress, extends a cross species approach in exploring neural mechanisms that link stress, anxiety, and excessive alcohol intake.

Alcohol abuse and alcoholism result from a complex interplay of genetic and environmental factors. Many aspects of an individual's response to the environment activate the hypothalamic-pituitary-adrenal (HPA) axis and are therefore labeled as "stress." Much of the stress in modern society is a subjective state of anxiety, where competing goals generate conflict and activate brain mechanisms involved in arousal and attention. These stressful states are often seemingly relived by drinking alcohol and may be a primary factor in establishing excessive alcohol consumption.

While there is a great deal of evidence supporting stress-alcohol interactions, less is known about how these interactions alter the brain at the molecular, cellular and systems levels to maintain excessive drinking and alcoholism and why this addiction is so difficult to treat. This consortium is tackling the larger picture of genetic influences on the brain mechanisms that mediate the response to alcohol, the response to stress, and the reciprocal relationship between excessive drinking, the physiological state of stress and the subjective state of anxiety.

The consortium's main approach will be to characterize the genetic basis of key neural mechanisms in stress and anxiety in order to clearly assess individual risk for the development of alcoholism or to develop tailored therapeutic approaches to treating the anxious alcoholic.

The grant represents the first competitive renewal for the INIA consortium, which is made up of 20 lead investigators from 11 institutions from the United States and Europe. The group received its initial round of funding in 2001. The other institutions involved are: University of Tennessee Health Sciences Center; Medical University of South Carolina; Wake Forest University; University of Texas Southwest; Virginia Commonwealth University; Oak Ridge National Laboratory; Vanderbilt University; University of Oklahoma Health Sciences Center; Furman University; University of Maine; and University of Cagliari, Italy.

To date, the consortium has made significant scientific progress. Accomplishments include: The consortia has published over 100 articles on the topic of genetic and environmental components of alcohol-stress interactions, the production of unique, genetically altered, mice for addressing the role of key genes in stress, anxiety and alcoholism, a growing data base of translational research linking findings from mice, non human primates and human beings, and supporting the inclusion of new investigators into the realm of alcohol research.

The NIAAA is one of the 18 institutes that comprise the National Institutes of Health. It supports and conducts biomedical and behavioral research on the causes, consequences, treatment, and prevention of alcoholism and alcohol-related problems. Visit www.niaaa.nih.gov for more information.

About Oregon Health & Science University
OHSU is the state's only comprehensive public academic health center. Its fundamental purpose is to improve the health and well being of people in Oregon and beyond. As part of its multifaceted public mission, OHSU strives for excellence in education, research and scholarship, clinical practice and community service. Through its dynamic interdisciplinary environment, OHSU stimulates the spirit of inquiry, initiative, and cooperation among students, faculty and staff. OHSU is made up of the schools of Medicine, Dentistry, Nursing, and School of Science & Engineering.

Kettil Bruun Society Early Career Scientist Award


The Kettil Bruun Society is an international and multidisciplinary society, aiming to promote social and epidemiological research which fosters comparative understanding of the social aspects of alcohol problems in different countries and across different sub-populations.

The purpose of the KBS Early Career Scientist Award is to recognize the excellence of the papers presented by early career scientists at the KBS Annual Symposium held each year in early June. The award is a cash prize of 250 Euros and two years membership of the Kettil Bruun Society.

The best paper presented by an early career scientist will be selected by a scientific committee, based on its contribution to advancing knowledge in alcohol research and on its theoretical and methodological quality.

The winner will be announced and the award presented towards the end of the meeting.

Eligibility:

Applicants who:

- are students studying for their masters or doctoral degree or early career scientists who have obtained their doctoral degree within the last two years.
- are presenting a paper as a first author.

Application

The June 2006 award has been presented. For the future, applicants must send their full conference paper to Tim Stockwell, KBS President (timstock@uvic.ca) along with a covering letter stating how long the applicant has been engaged in social and/or epidemiological research on alcohol and the year they obtained their PhD if applicable.

2006 Selection committee

Tim Stockwell , Henk Garretsen, Deborah Dawson and Kate Graham.

The NSDUH Report:
Co-Occurring Major Depressive Episode and Alcohol Use Disorder among Adults


Combined data from SAMHSA's 2004 and 2005 National Surveys on Drug Use and Health were used to examine co-occurring alcohol use and depression as well as treatment for these disorders in adults aged 18 or older.

The following prevalence were found: An estimated 7.6% of adults aged 18 or older (approximately 16.4 million adults) had experienced at least one major depressive episode during the past year. An estimated 8% (17.3 million adults) met criteria for alcohol use disorder in the past year. An estimated 1.2% (2.7 million adults) had co-occurring major depressive episode and alcohol use disorder in the past year.

Among adults with past year co-occurring major depressive episode and alcohol use disorder, 48.6% received treatment only for major depressive episode, 1.9% received treatment at a specialty facility only for alcohol use disorder, and 8.8% received treatment for both problems. About 40% received no treatment.

The rate of past year alcohol use disorder was over twice as high among adults who had experienced a major depressive episode (16.2%) compared with adults who had not experienced a major depressive episode in the past year (7.3%).
The NSDUH Report: Health Insurance and Substance Use Treatment Need

  • Health insurance and the need for and receipt of substance abuse treatment among adults aged 18 or older was examined based on combined 2004 and 2005 SAMHSA National Surveys on Drug Use and Health. Types of health insurance included Medicare, Medicaid/CHIP, military health care, and private insurance. An annual average of 85.4% adults had some type of health insurance in the past year and 70.5% had private health insurance. Adults needing substance abuse treatment in the past year were less likely to have some type of health insurance coverage in the past year than adults not needing treatment (74.4% vs. 86.6%).
  • About half (51.2%) of the adults needing treatment whose last treatment in the past year was at a specialty substance abuse treatment reported that some type of health insurance (private insurance, Medicare, Medicaid, military health care, or other insurance) paid for the services.
Download full report
30thAnnual Scientific Meeting of the Research Society on Alcoholism



July 7-12, 2007
Hyatt Regency, Chicago, Illinois

Following is a list of all of the information that can be found on our Meeting Page. If you will be attending the meeting, after you register, please take a moment to fill out the �Please Help Us� form. Also, be sure to send us your verification letters if you are a non-member student or non-member post-doc. Any questions, please do not hesitate to contact us at DebbyRSA@sbcglobal.net or 512-454-0022. See you in Chicago.





Please contact Debby (DebbyRSA@sbcglobal.net) for more information
CADCA Broadcast Explores Impact of Stress on Substance Abuse

March 15, 2007


All of us have stress in our lives, but stress means different things to different people and causes varying reactions. While some can handle life stresses internally, others look for something to make them feel better—such as drugs and alcohol. Scientific research has shown a strong link between stress and substance abuse and it´s also one of the most powerful triggers for relapse, even after long periods in recovery. During an hour-long broadcast hosted by CADCA, experts will discuss the brain´s response to stress and the link between stress and substance abuse.

Stress-Induced Substance Abuse will be held on March 29, 2007 from 1-2 p.m. EST.

The broadcast will feature leading experts in the fields of substance abuse research and treatment, and mental health, including:

• Doctor William Shoemaker, Associate Professor of Psychiatry, University of Connecticut. He has many years of experience researching the effects of alcohol and other drugs on the brain and how stress often triggers drug use.

• Kay Daughty, Vice President of Family and Community Services, Operation PAR, Pinellas Park, FL

• Bert Bauer, Licensed Clinical Social Worker, Pathways New Learning Center, Atlanta, GA; and recently retired from the Army Reserve Command after 40 years of military service, where he provided mental health services to the active duty military.

• Edward Carlson, Executive Director, Odyssey House Louisiana

• John King, Executive Director, Council on Alcohol and Drug Abuse for Greater New Orleans


During the broadcast, panelists will discuss why stress may lead to substance abuse and how the brain responds to stressful situations or events. See how rates of alcohol and drug abuse increase after traumatic events such as military service, terrorist attacks, and natural disasters. Hear first-hand how many people struggling with the aftermath of Hurricane Katrina are looking for stress relief, often in dangerous ways, and find out how to identify who is at risk and see what treatment options work.

The broadcast will be webcast live at www.MCTFT.com and www.cadca.org. It can also be viewed at no cost from any site with a satellite dish having C-band downlink capabilities. All viewing sites must register in advance to receive the necessary satellite coordinates. To register, contact Ed Kronholm at 877-820-0305 or dlnets@aol.com. To register online, visit: www.dlnets.com/MCTFT2nd.htm.

CDontributor: Don Phillips
Increased QT interval variability index in acute alcohol withdrawal

Drug and Alcohol Dependence
Article in press 9 March 2007





Karl-Jürgen Bära , Email: Karl-Juergen.Baer@med.uni-jena.de

Michael Karl Boettgerb,

Mandy Koschkea,

Silke Boettgera,

Marei Grotelüschena,

Andreas Vossc and

Vikram K. Yeraganid, e

aDepartment of Psychiatry, Friedrich-Schiller-University, Jena, Germany
bInstitute of Physiology I, Friedrich-Schiller-University, Jena, Germany
cDepartment of Medical Engineering, University of Applied Sciences, Jena, Germany
dDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, USA
eDepartment of Psychiatry, University of Alberta, Edmonton, Canada

Received 13 September 2006; revised 14 January 2007; accepted 17 January 2007. Available online 9 March 2007.


Abstract

Objective

Acute alcohol withdrawal is associated with increased cardiovascular mortality, most likely due to cardiac arrhythmias. As the QT interval reflects the most critical phase for the generation of reentry and thus for arrhythmia, we examined QT variability in patients suffering from acute alcohol withdrawal.

Methods

High resolution electrocardiographic recordings were performed in 18 male unmedicated patients suffering from acute alcohol withdrawal, 18 matched controls and 15 abstained alcoholics. From these, parameters of beat-to-beat heart rate and QT variability such as approximate entropy and QT variability index (QTvi) were calculated. Measures were correlated with the severity of withdrawal symptoms and with serum electrolyte concentrations.

Results

Heart rate and QTvi were significantly increased in acute alcohol withdrawal. Abstained alcoholics did not significantly differ from controls. While QTvi correlated with the severity of alcohol withdrawal symptoms, the mean QT interval duration showed an inverse relationship with serum potassium concentrations.

Conclusion

Our data indicate increased QT variability and thus increased repolarization lability in acute alcohol withdrawal. This might add to the elevated risk for serious cardiac arrhythmias. In part, these changes might be related to increased cardiac sympathetic activity or low potassium, thus suggesting the latter as possible targets for adjuvant pharmacological therapy during withdrawal.




Corresponding author at: Department of Psychiatry, Friedrich-Schiller-University Jena, Philosophenweg 3, 07743 Jena, Germany. Tel.: +49 3641 935282; fax: +49 3641 936217.
Experts call for booze crackdown
Man drinking pint
The pressure group is concerned over the availability of cheap drink
A pressure group has called for a Scottish Parliament inquiry into alcohol-related health problems.

March 20, 2007

The move comes a month after Health Minister Andy Kerr announced a strategy for tackling alcohol abuse.

Scottish Health Action on Alcohol Problems (SHAAP) is particularly worried about low-cost drink promotions in supermarkets and off-licences.

The group will present a petition to the parliament on Tuesday and will publish its parliamentary manifesto.

The organisation wants the health and community care committee to lead an inquiry into Scotland's alcohol problems.

It wants the Scottish Executive to look at extending the promotions mechanism in the Licensing (Scotland) Act to cover supermarkets, off-licences and shops as a means of preventing the low-cost promotion and sale of alcohol.

Stricter enforcement

The SHAAP manifesto calls for alcohol to be displayed separately from other goods in shops.

It recommends stricter enforcement of laws relating to alcohol use and residential programmes for people with alcohol problems throughout Scotland.

The appeal comes after school pupils last year petitioned parliament over concerns about the health implications of cheap alcohol and urged ministers to investigate.

The youngsters from All Saints School in Glasgow found that alcohol was often cheaper than bottled water.

The lower the cost of alcohol, the more alcohol is consumed and the worse our alcohol-related health problems become
Dr Bruce Ritson

Dr Bruce Ritson, chair of SHAAP, said alcohol was undermining the nation's health.

"The association between price and increased consumption of alcohol is well established in academic and medical circles, but perhaps less well known publicly," he said.

"Speaking plainly, the lower the cost of alcohol, the more alcohol is consumed and the worse our alcohol-related health problems become."

The executive published its strategy on alcohol abuse last month which included rolling out a scheme to crack down on retailers who sold alcohol to under-18s.

SHAAP is a medical advocacy group set up by the Scottish Medical Royal Colleges and Faculties to raise awareness of the costs of excessive alcohol consumption.
Multi-component programmes


An approach to prevent and reduce alcohol-related harm
Betsy Thom and Mariana Bayley

This report reviews international experience of community-based prevention programmes to
address alcohol-related harms at local level.

Debate following the publication of the Alcohol Harm Reduction Strategy for England
(2004) and the implementation of the Licensing Act (2003) raised concerns about the cost of
alcohol misuse to individuals and communities. A key part of national strategy is a focus on
local responsibility for policy implementation and an expectation that stakeholders – local
authorities, professional groups, the alcohol trade and ‘communities’ – will work together to
reduce the problems.

The report describes a ‘multi-component’ model to prevent and reduce harm, with evidence
from programmes in the USA, Australia and Scandinavia. The approach typically requires
a programme of multiple, co-ordinated initiatives rather than ‘stand-alone’ projects, and an
emphasis on encouraging change in local policies, structures, systems and drinking cultures.
The involvement of local communities is central to most programmes. The report reveals
problems in implementing and sustaining this approach as well as the advantages it offers.
Discussions with a small group of professionals showed widespread use of ‘partnership’
approaches and suggested that the use of a more explicit multi-component model would be
helpful to map alcohol-related problems and design local strategies.

Multi-component programmes will be of interest to policymakers, researchers and professionals
working at local level.

Download the report free of charge (PDF, 438KB)

Monday, March 19, 2007

The lack of CB1 receptors prevents neuroadapatations of both NMDA and GABAA receptors after chronic ethanol exposure

Journal of Neurochemistry (OnlineAccepted Articles).
12 March 2007

  • *Equipe Région INSERM 24 (ERI24), Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), Université de Picardie Jules Verne, Faculté de Pharmacie, 1 rue des Louvels, Amiens, France; +Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Université libre de Bruxelles, Bât C, Bruxelles, Belgium.
* Address correspondence and reprint requests to Dr M Naassila, Equipe Région INSERM 24 (ERI 24), Groupe de Recherche sur l'Alcool et les Pharmacodépendances (GRAP), Université de Picardie Jules Verne, Faculté de Pharmacie, 1 rue des Louvels, 80000 Amiens, France, Tél: +33 3 22 82 77 58, Fax: +33 3 22 82 76 72. E-mail: mickael.naassila@u-picardie.fr

Abstract

Because the contribution of CB1 receptors in the neuroadaptations following chronic alcohol exposure is unknown we investigated the neuroadaptations induced by chronic alcohol exposure on both NMDA and GABAA receptors in CB1-/- mice.

Our results show that basal levels of hippocampal [3H]MK-801 binding sites were decreased in CB1-/- mice and that these mice were also less sensitive to the locomotor effects of MK-801.

Basal level of both hippocampal and cerebellar [3H]muscimol binding was lower and sensitivity to the hypothermic effects of diazepam and pentobarbital was increased in CB1-/- mice.

GABAA α1, β2, γ2 and NMDA NR1, NR2B subunit mRNA levels were altered in striatum of CB1-/- mice.

Our results also showed that [3H]MK-801 binding sites were increased in cerebral cortex and hippocampus after chronic ethanol ingestion only in wild-type mice.

Chronic ethanol ingestion did not modify the sensitivity to the locomotor effects of MK-801 in both genotypes. Similarly, chronic ethanol ingestion reduced the number of [3H]muscimol binding sites in cerebral cortex, but not in cerebellum, only in CB1+/+ mice.

We conclude that lifelong deletion of CB1 receptors impairs neuroadaptations of both NMDA and GABAA receptors after chronic ethanol exposure and that the endocannabinoid/CB1 receptor system is involved in alcohol dependence.

___________________________________________________________________

Integrated Treatment to Persons With Mental Disorders and co-Occurring Substance Use Disorders (ROP)

This study is not yet open for patient recruitment.
Verified by SINTEF Health Research March 2007

Sponsors and Collaborators: SINTEF Health Research
The Research Council of Norway
University of Oslo
Information provided by: SINTEF Health Research
ClinicalTrials.gov Identifier: NCT00447733

Purpose

The purpose of this study is to determine whether integrated treatment is effective in the treatment of mental disorders and co-occurring substance use disorders.
Condition Intervention Phase
Anxiety Disorders
Mood Disorders
Substance Use Disorders
Behavior: Integrated mental health and substance misuse treatment
Phase II
Phase III

MedlinePlus related topics: Anxiety; Drug Abuse; Mental Health

Study Type: Interventional
Study Design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Efficacy Study

Official Title: Effects of Integrated Treatment to Persons With Mental Disorders and co-Occurring Substance Use Disorders

Further study details as provided by SINTEF Health Research:
Primary Outcomes: alcohol and drug use at baseline, six and twelve months; Psychopathology at baseline, six and twelve months; Global functioning at baseline, six and twelve months
Secondary Outcomes: Quality of life at baseline, six and twelve months; Therapist alliance at six and twelve months; Treatment fidelity at six and twelve months
Expected Total Enrollment: 150

Study start: March 2007; Expected completion: December 2008

Patients with mental disorders and co-occuring substance use disorders are characterized by high suicide and treatment drop-out rates, and long-lasting interpersonal, work, school, health and legal problems. And because mental disorders and substance use disorders interact and co-exists, it may be important to provide treatment that integrates their substance misuse and mental health problems in a comprehensive way. The health services for patients with mental health and substance use disordes are usually provided by different services and health professionals that rarely cooperate or have qualifications on both kinds of disorders. The over-all aim of the study is to evaluate the effects of evidence-based integrated and comprehensive treatment of mental health problems and co-occurring substance use disorders. The effects of the treatment will be assesses on substance use,psychopathology, and quality of life.

Comparison: patients receiving treatment-as-usual or non-manualized treatment at general mental health outpatients clinics.

Eligibility

Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria

Inclusion Criteria:

  • clinical diagnosis of substance use disorder
  • clinical diagnosis of anxiety disorders
  • clinical diagnosis of nonpsychotic mood disorders
  • written consent
  • planning to live in the catchment area during the treatment

Exclusion Criteria:

  • schizophrenia spectrum disorders
  • other psychotic disorders
  • mental retardation
  • having nicotine abuse/dependency only

Location and Contact Information

Please refer to this study by ClinicalTrials.gov identifier NCT00447733
Rolf W. Grawe, Ph.D 92221971 Ext. 0047 rolf.w.grawe@sintef.no
Amund Aakerholt, Ph.D 97599473 Ext. 0047 amund.aakerholt@iris.no

Norway
SINTEF Health Research, Trondheim, 7465, Norway
Rolf W. Gråwe, Ph.D 92221971 Ext. 0047 rolf.w.grawe@sintef.no

Study chairs or principal investigators

Rolf W. Gråwe, Ph.D, Principal Investigator, SINTEF Health Research

More Information

substance abuse treatment for persons with co-occurring disorders

Study ID Numbers: 78i068; NFR175394/V50
Last Updated: March 14, 2007
Record first received: March 14, 2007
ClinicalTrials.gov Identifier: NCT00447733
Health Authority: Norway: Norwegian Social Science Data Services
ClinicalTrials.gov processed this record on 2007-03-19
Proposals for Mental Health Parity Pit a Father’s Pragmatism Against a Son’s Passion


By ROBERT PEAR
Published: March 19, 2007

WASHINGTON, March 18 — It’s Kennedy versus Kennedy as two members of Congress from the same family face off over competing versions of legislation that would require many health insurance companies and employers to provide more generous benefits to people with mental illness.

Representative Patrick J. Kennedy, Democrat of Rhode Island and chief sponsor of the House bill, has criticized as inadequate the Senate bill introduced by his father, Senator Edward M. Kennedy, Democrat of Massachusetts. Representative Kennedy is trying to mobilize mental health advocates to lobby for what he describes as “the stronger of the two bills, the House bill.”

Both bills seek to end discrimination against people with mental disorders by requiring insurers and employers to provide equivalent coverage, or parity, for mental and physical illnesses.

That would be a huge change. For decades, insurers have charged higher co-payments and set stricter limits on coverage of mental health services. For example, insurers often refuse to cover more than 20 visits a year to a psychotherapist. And a patient may have to pay 20 percent of the cost for visiting a cancer specialist, but 40 percent or more for a mental health specialist.

The differences between the Kennedys’ bills reflect different views about what is possible and what is politically feasible.

Senator Kennedy said he was taking a pragmatic approach and had made a number of compromises to win the support of business and insurance groups. These compromises, he said, greatly increased the chances that a bill would become law, protecting millions of Americans in group health plans.

Insurers and employers had opposed similar proposals in the past, saying the plans would drive up costs. This year, however, Senator Kennedy invited employers and insurers to help write the legislation, along with mental health groups, and they have endorsed the bill that he introduced with Senator Pete V. Domenici, Republican of New Mexico. The bill was recently approved in a Senate committee by a vote of 18 to 3.

The younger Kennedy approaches the issue with the passion of a man who has been treated for depression and drug dependence. He has advocated parity legislation since 2001, but he said his commitment increased when he became “the public face of alcoholism and addiction” last year after a car crash on Capitol Hill.

With a new Democratic majority, Congress appears likely to pass some version of the legislation. President Bush has endorsed the principle of mental health parity, though not a specific bill.

Nearly 60 percent of all House members have expressed support for the House bill, which provides more protections to patients but is not backed by insurers or employers.

“The House bill is everything that we did not like in previous mental health parity bills,” said E. Neil Trautwein, a vice president of the National Retail Federation, a trade group.

Speaking to mental health advocates this month, Representative Kennedy declared: “We can’t cut any deals with insurance companies. We need to strengthen the Senate bill.”

America’s Health Insurance Plans, which represents 1,300 insurers, and the American Benefits Council, a trade group mostly of Fortune 500 companies, strongly prefer the Senate version.

The American Psychiatric Association supports both bills, describing them as different approaches to the same goal. Mental Health America, an advocacy group for patients, also supports both bills. But Ralph J. Ibson, the chief lobbyist for Mental Health America, said, “The House bill has greater protections and is therefore a stronger bill.”

The House bill is named for Paul Wellstone, the senator from Minnesota who championed similar legislation before he died in a plane crash in 2002. Jeff Blodgett, executive director of Wellstone Action, a nonprofit group that is continuing the Democratic senator’s work, said, “The Senate bill is a step forward, but the House version is true to Paul Wellstone’s vision.”

On behalf of the senator’s sons, David and Mark Wellstone, Mr. Blodgett said, he asked the Senate sponsors not to put the Wellstone name on the Senate bill at this time.

One of the biggest differences between the House and Senate bills is that the House version defines the “minimum scope of coverage.” Under the House bill, if a group health plan provides any mental health benefits, then it must cover the same wide range of mental illnesses and addiction disorders covered by the health plan with the largest enrollment of federal employees.

By contrast, the Senate bill does not specify what mental conditions or diagnoses must be covered.

James A. Klein, president of the American Benefits Council, said he liked the Senate bill because it “does not mandate the specific benefits that a plan must cover.”

But Patrick Kennedy said that was a weakness of his father’s bill.

“Congress is covered, under the Federal Employees Health Benefits Program, for the treatment of mental illnesses as defined by the medical community,” Representative Kennedy said in an interview. “If it’s good enough for members of Congress, it should be good enough for the American public. The Senate bill leaves the definition up to whatever is negotiated between the insurer and the employer.”

Representative Kennedy said he feared that some insurers would refuse to cover drug and alcohol abuse, eating disorders, or post-traumatic stress disorder.

A patient’s ability to get treatment at an affordable price often depends on state law. The National Conference of State Legislatures says that 42 states have some type of parity law.

The House bill says that federal law will not override “any state law that provides greater consumer protections, benefits,” rights or remedies. The Senate bill, by contrast, would “supersede any provision of state law” that establishes standards different from the federal standards for cost-sharing and treatment limits.

Karen M. Ignagni, president of America’s Health Insurance Plans, praised this provision of the Senate bill, saying it would help “achieve consistency on how parity is defined” in different states.

But Senators Christopher J. Dodd, Democrat of Connecticut, and Bernard Sanders, independent of Vermont, expressed concern that the Senate bill could interfere with laws in their states.

Senator Kennedy said he was confident that he and his son could resolve their differences. “We will find ways of working together,” he said.

Contributor: Don Phillips

Flavored Malt Beverages



The Board uses a thorough and public process to explore regulatory issues. Board of Equalization staff plan to meet with businesses, taxpayers, and other interested parties to discuss the application of California’s Alcoholic Beverage Tax to flavored malt beverages. Any member of the public may attend these meetings. After reviewing all input, staff will prepare a report for the Board to consider before it takes final action.

Review Schedule:

February 22 - 10:00 am
Interested Parties Meeting
450 N Street, Sacramento, Room 121
Letter to Interested Parties
NEW Audio Recording of February 22 meeting

Meeting of Interested Parties to Discuss
Flavored Malt Beverages

Board of Equalization Headquarters, Sacramento
Thursday, February 22, 2007 10:00 AM Pacific
The Board uses a thorough and public process to explore regulatory issues. Board of Equalization staff plan to meet with businesses, taxpayers, and other interested parties to discuss the application of California�s Alcoholic Beverage Tax to flavored malt beverages. Any member of the public may attend these meetings. After reviewing all input, staff will prepare a report for the Board to consider before it takes final action.