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Friday, May 3, 2013

Short term alcohol consumption may have detrimental effect on fibrinolysis and endothelial function - a preliminary report of prospective randomized study.

The study was designed to clarify the impact of short-term consumption of different types of alcoholic beverages on haemostatic factors, C-reactive protein (hsCRP) and endothelin-1 (E-1) plasma levels.

The study group consisted of 57 healthy male volunteers, aged 20-29 years. Subjects were randomized to consume 300 ml of either: red wine, white wine, 12% ethanol, blackcurrant juice or water for five days. Blood samples were collected for C-reactive protein, tissue type plasminogen activator antigen (t-PA:Ag), plasminogen activator inhibitor antigen (PAI-1:Ag) and endothelin-1 at baseline, on day 2, and on day 6.

Significant increase in PAI-1:Ag concentration was observed in red wine drinking group (day 1 - 44.98; day 2 - 56.86; day 6 - 47.44 ng/ml; p 0.05). Similar increase of endothelin level was found in 12% ethanol group (day 1 - 0,53 day 2 - 1,65 day 6 - 1,11 fmol/ml; p 0.01). Dividing the whole study group according to ethanol content of consumed beverages revealed significant changes in tPA:Ag, PAI-1:Ag and endothelin levels. In the alcohol drinking group significant increase of PAI-1:Ag (day 1 - 44.75; day 2 - 54.07; day 6 - 44.80 ng/ml; p.

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