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Thursday, August 25, 2011

Conditioned Tolerance to the Effects of Alcohol on Inhibitory Control in Humans



To test whether the repeated consumption of alcohol in a particular environment leads to the emergence of a context-specific conditioned compensatory response (CCR) that can counter alcohol's impairment of inhibitory processes.

Twenty-four participants consumed an alcoholic drink (males: 0.65 g/kg; females: 0.57 g/kg) in one context on three sessions and a matched placebo drink in a different context on three other sessions. At test, participants were split into two groups and consumed a novel alcoholic drink either in the context previously paired with alcohol or the placebo-paired context. On all sessions, participants were tested on two computer-based tasks that measured response inhibition: an affective go/no-go task and a stop-signal task (SST).

Over the conditioning trials, tolerance developed to alcohol's disinhibitory effects on the go/no-go task; moreover, on the test for conditioned responding, performance was less impaired for participants in the alcohol-paired versus the placebo-paired context. No tolerance was evident on the SST, and no CCR.

Repeated consumption of alcohol in a particular environment can lead to the emergence of a context-specific CCR that counters some of alcohol's disinhibitory effects. Therefore, consuming alcohol in an unfamiliar context might produce stronger disinhibitory effects than would be apparent in a familiar drinking environment.




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