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Monday, August 16, 2010

Biomarker Testing to Estimate Under-Reported Heavy Alcohol Consumption by Persons with HIV Initiating ART in Uganda


Alcohol affects the transmission and treatment of HIV, yet may be under-reported in resource-limited settings.

We compared self-reported alcohol consumption with levels of plasma carbohydrate-deficient
transfrrin (%CDT), a biomarker of heavy alcohol consumption, in persons initiating antiretroviral therapy in Uganda.

Almost seven percent (6.7%) of persons reporting abstaining and 10% reporting consuming 1–40 drinks in the prior month tested positive for %CDT, and actual under-report may be higher due to low sensitivity of %CDT.

These results suggest likely under-report in those reporting abstaining and current drinking. Improved identification of heavy alcohol consumption is needed for research and clinical
purposes.


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