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Wednesday, February 17, 2010

Effects of Adolescent Ethanol Exposure on Event-Related Oscillations (EROs) in the Hippocampus of Adult Rats


Electrophysiological studies have shown that adolescent ethanol (EtOH) exposure can produce long-term changes in hippocampal EEG and ERP activity.

Recently, evidence has emerged suggesting that event-related oscillations (EROs) may be good indices of alcoholism risk in humans, however, have not been evaluated for their ability to index the effects of EtOH exposure.

The objective of the present study was to characterize EROs generated in hippocampus in adult rats exposed to EtOH during adolescence.

Adolescent male Sprague-Dawley rats were exposed to EtOH vapor for 12 h/d for 10 days. A time-frequency representation method was used to determine delta, theta, alpha and beta ERO energy and the degree of phase variation in the hippocampus of adult rats exposed to EtOH and age-matched controls.

The present results suggest that the decrease in P3 amplitudes, previously observed in adult rats exposed to EtOH during adolescence, is associated with increases in evoked theta ERO energy.

These studies suggest that EROs are suitable for characterizing the long-term effects of adolescent EtOH exposure.

Further studies are needed to determine the relationship between the mechanisms that regulate these neurophysiological endophenotypes and the consequences of adolescent EtOH exposure.

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Request Reprint E-Mail: cindye@scripps.edu

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