Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

___________________________________________

Tuesday, October 6, 2009

Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence
Pharmacogenetics and Genomics: POST AUTHOR CORRECTIONS, 1 October 2009

To examine the association between genetic variability of IL-1B, which encodes for the proinflammatory cytokine IL-1[beta] and the risk of developing opioid dependence. To confirm a previous study, we also examined the association between the IL-1B genetic polymorphism and alcohol dependence.

This study confirms the previous finding that IL-1B polymorphism is associated with altered risk of alcohol dependence. IL-1B single nucleotide polymorphisms at position -511 and -31, which increase IL-1[beta] production, occur at a higher frequency in opioid-dependent populations and may be associated, albeit weakly, with an increased risk of opioid dependence.


Request Reprint E-Mail: mark.hutchinson@adelaide.edu.au
__________________________________________________________________________
at