To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.


Sunday, October 11, 2009

Alcohol and hypertension: gender differences in dose–response relationships determined through systematic review and meta-analysis
Addiction  Early View 5 Oct 2009

To analyze the dose–response relationship between average daily alcohol consumption and the risk of hypertension via systematic review and meta-analysis.
A total of 12 cohort studies were identified from the literature from the United States, Japan and Korea. A linear dose–response relationship with a relative risk of 1.57 at 50 g pure alcohol per day and 2.47 at 100 g per day was seen for men. Among women, the meta-analysis indicated a more modest protective effect than reported previously: a significant protective effect was reported for consumption at or below about 5 g per day, after which a linear dose–response relationship was found with a relative risk of 1.81 at 50 g per day and of 2.81 at an average daily consumption of 100 g pure alcohol per day. Among men, Asian populations had higher risks than non-Asian populations.

The risk for hypertension increases linearly with alcohol consumption, so limiting alcohol intake should be advised for both men and women.

Read Full Abstract

Request Reprint E-Mail: