Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

___________________________________________

Wednesday, July 1, 2009

Decreased somatostatin is related to the hypersensitivity of intestinal epithelia to LPS via upregulated TLR4–TBK1 pathway in rats chronically exposed to ethanol
Alcohol Volume 43, Issue 4, June 2009, Pages 293-303

Chronic alcoholics are predisposed to the development of a systemic inflammatory response syndrome, which is usually triggered in the gut. This study aimed to investigate in rats the role of intestinal epithelial inflammatory responsiveness in the susceptibility of alcoholics to excessive inflammation.

These findings suggest that impairment of intestinal SST production by chronic ethanol administration leading to upregulation of the TLR4–TBK1 pathway may be one of the mechanisms underlying the LPS hypersensitivity of intestinal epithelia.


Request Reprint E-Mail: cwtang@medmail.com.cn

_______________________________________________________________
at