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Tuesday, July 22, 2008

Circadian phenotype in patients with the co-morbid alcohol use and bipolar disorders
Alcohol and Alcoholism Advance Access published online on July 20, 2008


Alcohol misuse is associated with bipolar disorder. Abnormalities in the circadian clockwork play a role in the pathogenesis of bipolar disorder. Alcohol intake is likely to affect the circadian phenotype.

We aimed at analysing the behavioural trait of the preference to morning or evening hours for the daily activities in bipolar disorder patients with or without the co-morbid alcohol use.

Patients with the co-morbid alcohol use disorder were more of the morning type as compared with patients with bipolar disorder only.

Co-morbid patients preferred more the morning hours for their daily activities, indicative of alcohol consumption having an effect on the circadian clock.

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