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Tuesday, September 11, 2007

Twin Pair Resemblance for Psychiatric Hospitalization in the Swedish Twin Registry: A 32-year Follow-up Study of 29,602 Twin Pairs
Behavior Genetics Volume 37, Number 4 / July, 2007



Allgulander et al. published twin pair analyses of psychiatric hospitalization for like-sex pairs from the Swedish Twin Registry born 1926–1958.

The present report updates the prior results by using 17 additional years of follow-up, including members of opposite-sex twin pairs, and addressing biases arising from cohort effects and from excluding pairs with unknown zygosity.

Inclusion of additional follow-up information, opposite-sex twin pairs, age-adjustment, and use of current ICD definitions yielded higher heritability estimates for alcoholism, anxiety disorders, and psychosis than previously published for this nationally-representative sample of twins from Sweden.

The results show that relatively small selection biases can alter twin study results and underscore the importance of addressing under-ascertainment of cases in genetic research based on volunteers.

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Reprint request E-Mail: cprescot@usc.edu
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