Dopaminergic dysfunction has been hypothesized to play an important role in the etiology of alcohol-use disorders.
A restriction fragment length polymorphism (RFLP) in the 3 untranslated region (3UTR) of the DRD2 gene affects gene expression and has been implicated as a risk factor for alcohol dependence.
This polymorphism (TaqIA) has been reported as positively associated with alcohol-use disorders in case-control samples, but these results have not been replicated in family-based association studies.
This study supports other family-based association tests that have reported no association between the DRD2 TaqIA polymorphism and alcohol abuse and dependence.
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