Aims

To support the free and open dissemination of research findings and information on alcoholism and alcohol-related problems. To encourage open access to peer-reviewed articles free for all to view.

For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.

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Wednesday, May 19, 2010

Factors Associated with Favorable Drinking Outcome 12 Months After Hospitalization in a Prospective Cohort Study of Inpatients with Unhealthy Alcohol



Prevalence of unhealthy alcohol use among medical inpatients is high.

To characterize the course and outcomes of unhealthy alcohol use, and factors associated with these outcomes.

At baseline and 12 months later, consumption and alcohol-related consequences were assessed. The outcome of interest was a favorable drinking outcome at 12 months (abstinence or drinking “moderate” amounts without consequences). The independent variables evaluated included demographics, physical/sexual abuse, drug use, depressive symptoms, alcohol dependence, commitment to change (Taking Action), spending time with heavy-drinking friends and receipt of alcohol treatment (after hospitalization). Adjusted regression models were used to evaluate factors associated with a favorable outcome.

Thirty-three percent had a favorable drinking outcome 1 year later. Not spending time with heavy-drinking friends [adjusted odds ratio (AOR) 2.14, 95% CI: 1.14–4.00] and receipt of alcohol treatment [AOR (95% CI): 2.16(1.20–3.87)] were associated with a favorable outcome. Compared to the first quartile (lowest level) of Taking Action, subjects in the second, third and highest quartiles had higher odds of a favorable outcome [AOR (95% CI): 3.65 (1.47, 9.02), 3.39 (1.38, 8.31) and 6.76 (2.74, 16.67)].

Although most medical inpatients with unhealthy alcohol use continue drinking at-risk amounts and/or have alcohol-related consequences, one third are abstinent or drink “moderate” amounts without consequences 1 year later. Not spending time with heavy-drinking friends, receipt of alcohol treatment and commitment to change are associated with this favorable outcome. This can inform efforts to address unhealthy alcohol use among patients who often do not seek specialty treatment.


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Request Reprint E-Mail: Nicolas.Bertholet@chuv.ch


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Labour's 24 hour drinking laws could be scrapped


Theresa May, the Home Secretary, said she is determined to examine problems created by the ''binge-drinking culture'', including street violence and other crimes.

Speaking at the Police Federation conference, she said she opposed the 2003 Licensing Act when it was introduced by the previous administration. . . . . .

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UN General Assembly ask for High Level meeting on Non-Communicable Diseases


Thursday 13 May the UN General Assembly concluded its consideration of the agenda item 114, Follow-up to the outcome of the Millennium Summit. It passed the draft resolution A/64/L.52 introduced by the representative of Trinidad and Tobago (on behalf of the Caribbean Community). The resolution “Prevention and control of non-communicable diseases” was according to NGO reports from the meeting co-sponsored by some one hundred countries.

The resolution draws up the background by pointing to various international health documents related to non-communicable diseases. It is also recognizing “the enormous human suffering caused by non-communicable diseases” and that these diseases are leading to increasing inequalities between countries and populations, thereby threatening the achievement of the internationally agreed development goals, including the Millennium Development Goals,”

Further in the text of the resolution the General Assembly is “noting the call to consider integrating indicators to monitor the magnitude, the trend and socio-economic impact of non-communicable diseases into the Millennium Development Goals monitoring system,”

Of interest to the alcohol field is the mentioning with appreciation in the text of the various World Health Assembly resolutions and decisions. This is including the evidence-based strategies and interventions to reduce the public health problems caused by the harmful use of alcohol. The UN resolution also points to alcohol abuse as one of the prominent risk factors for non-communicable diseases. . . . . .

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Alcohol intake and endometrial cancer risk: a meta-analysis of prospective studies



Studies on alcohol intake in relation to endometrial cancer risk have produced inconsistent results.

For a meta-analysis, we identified cohort studies of alcohol and endometrial cancer by a literature search of Pub-Med and Embase up to 1 March 2010 and by searching the reference lists of relevant articles.

Seven cohort studies, including 1 511 661 participants and 6086 endometrial cancer cases, were included in the dose–response random-effect meta-regression model. Compared with non-drinkers, women drinking less than 1 drink of alcohol (13 g of ethanol) per day had a lower risk for endometrial cancer; this risk was lower by 4% (95% confidence interval (95% CI): 0.93–1.00) for consumption up to 0.5 drink per day and by 7% (95% CI: 0.85–1.02) for consumption up to 1 drink. However, we found evidence of an increased risk for endometrial cancer for intakes higher than two alcoholic drinks per day: compared with non-drinkers, the risk was higher by 14% (95% CI: 0.95–1.36) for 2–2.5 drinks per day and by 25% (95% CI: 0.98–1.58) for >2.5 drinks per day.

Our meta-analysis indicates a possible J-shaped relationship between alcohol intake and endometrial cancer risk.


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Request Reprint E-Mail: emilie.friberg@ki.se


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Alcohol consumption in Estonia and Finland: Finbalt survey 1994-2006


Alcohol consumption has been regarded as an important contributor to the high premature mortality rates. The objective of this paper was to provide an overview and comparison of alcohol consumption and its socio-demographic determinants among adults in Estonia and Finland

The study was based on a 25-64-year-old subsample of nationally representative postal cross-sectional surveys conducted in Estonia (n=10,340) and Finland (n=19,672) during 1994-2006. Abstinence, frequency, and the amount of alcohol consumed were examined. Logistic regression models were used to test the socio-demographic differences in alcohol consumption at least once a week. The effect of socio-demographic factors on pure alcohol consumed per week was calculated using linear regression.

The proportion of abstainers was 1.5 times higher among women than men in both countries. Throughout the study period, the amount of alcohol consumed per week increased for both genders in Estonia and for women in Finland, but was stable for men in Finland. In the final study year, medium risk amount of alcohol consumed per week was nearly 1.5 times higher among men in Estonia than in Finland, but about half that among women in Estonia than in Finland. Compared to ethnic majority in Estonia, alcohol consumption at least once a week was lower among men, but amount of pure alcohol drunk per week was higher among women of ethnic minority. In Finland, alcohol consumption at least once a week was more prevalent among women of ethnic minority, but the amount of pure alcohol drunk per week was lower for both gender groups of ethnic minority. Compared to married/cohabiting respondents, alcohol consumption at least once a week was less pronounced among single respondents in Finland, divorced or separated women in both countries, and widowed respondents in Estonia. Greater amount of alcohol consumed per week was more prevalent among single and divorced or separated respondents in Finland, but only among divorced or separated men in Estonia. Frequency of alcohol consumption was lower among less educated than higher educated respondents in Finland, but not in Estonia. The amount of consumed alcohol per week was higher among less educated men in Estonia, but lower among women with basic education in Finland.

Alcohol consumption has increased in Estonia and Finland. National alcohol policies should reflect findings of alcohol epidemiology in order to introduce measures that will reduce alcohol related harm in the population effectively.


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California The 2010-11 Budget: Overview of the May Revision


In the May Revision, the administration identifies a $17.9 billion gap between current-law resources and expenditures in California's 2010-11 General Fund budget. This estimate is reasonable.

In addressing the shortfall, the Legislature should reject the Governor's most drastic spending cuts, especially his proposed elimination of CalWORKs and child care funding. Alternative spending reductions could help sustain critical components of these core programs for the state's neediest families, and some of the Governor's most severe cuts could be avoided by adopting selected revenue increases.

The report also describes the Legislature's options in deciding how much education spending the state can afford in this difficult budget year, when elected leaders also need to focus on longer-term policy changes that will better prepare California to cope with future economic downturns.

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  • Targeted Tax Rate Increases. Finally, we have suggested the Legislature could consider targeted tax rate increases. Given the fragile state of the economy and the level of these taxes relative to other states, we discourage increasing the state’s broad–based big three taxes (personal income, sales and use, and corporation taxes) above their current levels. We have, however, suggested two proposals that would raise other tax rates while adhering to sound tax policy principles. First, many economists believe that taxes on alcohol do not fully compensate for the societal costs associated with drinking. Since alcohol tax rates have not been updated for inflation since 1991, such an adjustment could produce over $200 million of General Fund benefit. In addition, we suggest permanently aligning the VLF—currently increased temporarily under provisions of the February 2009 budget package—with local property tax rates, as it represents a tax on property.

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Variation in Nicotinic Acetylcholine Receptor Genes is Associated with Multiple Substance Dependence Phenotypes



There is shared genetic risk for dependence on multiple substances, and the nicotinic receptor gene cluster on chromosome 15 harbors multiple polymorphisms that associate to this risk.

Here, we report the results of an association study with 21 SNPs genotyped across the
CHRNA5, CHRNA3, and CHRNB4 loci on chromosome 15q25.1. The sample consists of a discovery set (N=1858) of European-American and African-American (AA) families, ascertained on the basis of a sibling pair with cocaine and/or opioid dependence, and a case–control replication sample (N=3388) collected for association studies of alcohol, cocaine, and opioid dependence.

We tested the SNPs for association with lifetime cocaine, opioid, nicotine, and alcohol dependence. We replicated several previous findings, including associations between rs16969968 and nicotine dependence (
P=0.002) and cocaine dependence (P=0.02), with opposite risk alleles for each substance. We observed these associations in AAs, which is a novel finding. The strongest association signal in either sample was between rs684513 in CHRNA5 and cocaine dependence (OR=1.43, P=0.0004) in the AA replication set.

We also observed two SNPs associated with alcohol dependence, that is, rs615470 in
CHRNA5 (OR=0.77, P=0.0006) and rs578776 (OR=0.78, P=0.001).

The associations between CD and rs684513, AD and rs615470, and AD and rs578776 remained significant after a permutation-based correction for multiple testing.

These data reinforce the importance of variation in the chromosome 15 nicotinic receptor subunit gene cluster for risk of dependence on multiple substances, although the direction of the effects may vary across substances.


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Request Reprint E-Mail:
joel.gelernter@yale.edu



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Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium



The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk.

Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type.

We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case–control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders.

We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86–2.23, for 60 or more g/day vs. >0 to <5 g/day).

A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02–4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63–2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake.

Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.


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Request Reprint E-Mail: d.michaud@imperial.ac.uk


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People who drink moderately 'are healthier than teetotallers'


Moderate drinkers have lower rates of heart disease, obesity and depression than people who abstain from alcohol entirely, the report indicates.

But while recent research has highlighted the health-giving properties of wine and some other alcoholic drinks, the authors of the latest study sound a note of caution.

Drinking modest amounts of alcohol does not necessarily maker you healthier, they claim.

Rather, people who enjoy alcohol without indulging to excess tend to be wealthier and more successful than average – the sort of people who look after other areas of their health.

Boris Hansel of the Pitié-Salpêtrière Hospital in Paris, who led the research, said: "Moderate alcohol intake is a powerful marker of a higher social level, superior general health status and lower cardiovascular risk.

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Relationship between alcohol intake, health and social status and cardiovascular risk factors in the urban Paris-Ile-De-France Cohort: is the cardiopr



Observational studies document the inverse relationship between cardiovascular disease (CVD) and moderate alcohol intake. However, the causal role for alcohol in cardioprotection remains uncertain as such protection may be caused by confounders and misclassification.

The aim of our study was to evaluate potential confounders, which may contribute to putative cardioprotection by alcohol.

We evaluated clinical and biological characteristics, including cardiovascular (CV) risk factors and health status, of 149 773 subjects undergoing examination at our Center for CVD Prevention (The Urban Paris-Ile-de-France Cohort). The subjects were divided into four groups according to alcohol consumption: never, low (less than or equal to10 g/day), moderate (10–30 g/day) and high (>30 g/day); former drinkers were analyzed as a separate group.

After adjustment for age, moderate male drinkers were more likely to display clinical and biological characteristics associated with lower CV risk, including low body mass index, heart rate, pulse pressure, fasting triglycerides, fasting glucose, stress and depression scores together with superior subjective health status, respiratory function, social status and physical activity. Moderate female drinkers equally displayed low waist circumference, blood pressure and fasting triglycerides and low-density lipoprotein-cholesterol. Alcohol intake was strongly associated with plasma high-density lipoprotein-cholesterol in both sexes. Multivariate analysis confirmed that moderate and low drinkers displayed better health status than did never drinkers. Importantly, few factors were causally related to alcohol intake.

Moderate alcohol drinkers display a more favorable clinical and biological profile, consistent with lower CV risk as compared with nondrinkers and heavy drinkers. Therefore, moderate alcohol consumption may represent a marker of higher social level, superior health status and lower CV risk


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Request Reprint E-Mail: boris.hansel@psl.aphp.fr


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Approaches to Alcohol and Drugs in Scotland A Question of Architecture


The chapters of this report are structured in such a way as to bring the reader through a narrative from start to finish about how the Forum sees the alcohol and drugs policy landscape of 2008 and how it envisions it might be in 2025 if damage is to be significantly reduced.

Faced by the complexity and far reaching influences of alcohol and drug use and misuse, the Forum selected 7 key areas as the basis of a comprehensive systems mapping approach Whilst being able to integrate the technicalities of cross-cutting policies and research, this approach also lends itself to telling the story and identifying key issues in simpler terms.


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Media and advertising influences on adolescent risk behaviour



When we are looking for factors that change behaviour we can look inside the individual for personal characteristics that make people vulnerable to engaging in risky behaviours and we can look outside the individual for features of the environment that encourage these behaviours.

This article briefly examines the way the media may influence the development of risky behaviours (e.g., drug use, sexual behaviour) in young people.


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Street-wise? Substance use in town and country as reported by young people



We have been interested in the differences between urban and rural schools for some time. There is perhaps a popular prejudice that our cities are associated more with use of alcohol and drugs than the countryside, but we haven't always been able to confirm such adifference in our figures. . . . . .


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Tuesday, May 18, 2010

US regulators urged to probe online alcohol marketing



A digital watchdog and public health group urged US authorities Tuesday to investigate the online marketing practices of alcoholic beverage companies and their impact on young people.

The appeal to the Federal Trade Commission (FTC) and state attorneys general came in a 34-page report issued by the Center for Digital Democracy (CDD) and the Berkeley Media Studies Group of the Public Health Institute. . . . . .

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News Release - Receptor Variant Influences Dopamine Response to Alcohol



A genetic variant of a receptor in the brain’s reward circuitry plays an important role in determining whether the neurotransmitter dopamine is released in the brain following alcohol intake, according to a study led by researchers at the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health. Dopamine is involved in transmitting the euphoria and other positive subjective effects produced by alcohol.

A report of the findings, which help explain the diverse genetic susceptibility for alcohol use disorders, will appear online in Molecular Psychiatry on May 18, 2010. . . . . .


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Press Release - Health Groups: FTC & State AGs Must Investigate Online Marketing of Alcohol Products & Impact on Youth



Alcohol companies are using the latest new media technologies to promote their products using methods that appeal to youth, explains a new report released today from the Center for Digital Democracy and Berkeley Media Studies Group of the Public Health Institute. “Alcohol Marketing in the Digital Age,” details how beer and alcohol companies are targeting consumers through social media, online video, mobile phone applications, and virtual online communities. Marketers are using these and other digital tools to harvest behavioral and other data on consumers, raising concerns about the effects such personalized interactive marketing may have on underage drinking, which The Center on Alcohol Marketing and Youth estimates to account for 12-20 percent of the U.S. alcohol market. The report also examines how alcohol companies are targeting African Americans and Hispanics.
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Alcohol Marketing in the Digital Age



This report surveys some of the major features of the contemporary marketing landscape and their connection to the promotion of alcoholic beverages. One of its goals is to alert stakeholders to some of the emerging practices that demand greater scrutiny. Many of these new interactive techniques may well fly under the radar of policy makers, parents, and public health professionals. If we are to develop timely and appropriate strategies to address concerns about underage drinking—and the use of alcoholic products by society generally—it is critically important that we understand the dimensions and implications of the new marketing paradigm.


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Internationally recognized guidelines for ‘sensible’ alcohol consumption: is exceeding them actually detrimental to health and social circumstances?



The health and social impact of drinking in excess of internationally recognized weekly (>21 units in men; >14 units in women) and daily (>4 units in men; >3 units in women) recommendations for ‘sensible’ alcohol intake are largely unknown.

In fully adjusted analyses, surpassing guidelines for sensible alcohol intake was associated with an increased risk of hypertension [daily guidelines only: P-value(trend): 0.012], financial problems [weekly guidelines: P-value(difference): 0.046] and, to a lesser degree, accidents [weekly guidelines: P-value(difference): 0.065]. There was no association between either indicator of alcohol intake and mortality risk.

In the present study, there was some evidence for a detrimental effect on health and social circumstances of exceeding current internationally recognized weekly and daily guidelines for alcohol intake.


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Figures on alcohol in the municipalities"



The purpose of this netpublikation is to give municipalities a status on alcohol field and to identify future challenges. The desire is that publication's figures may contribute to the planning and development of municipal alcohol action.

Prevention, early intervention and treatment of alcohol area is an important area for municipalities. Alcohol is very important for the Danish health. European figures show that alcohol causes 17% of the total disease burden. With local government reform the municipalities have been given a major responsibility on both the preventive and the therapeutic area as under the municipal responsibility for the citizen-oriented prevention and municipalities responsible for publicly funded alcohol treatment.

Alcoholic significant expenditure in the municipalities. The municipal spending is among the second to the financing of hospital care for people treated for effects of excessive alcohol consumption and alcohol treatment. But also for social spending in particular care of citizens, transfer income and expenses for relatives - including the placement of children outside the home.

When the number of people in publicly funded alcohol treatment or medical held up in comparison to the number of alcohol-dependent, it indicates that there is a pending location. Prevention and treatment options are good and there is therefore a great potential to exploit these more than it does today.


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A genetic determinant of the striatal dopamine response to alcohol in men


Excessive alcohol use, a major cause of morbidity and mortality, is less well understood than other addictive disorders. Dopamine release in ventral striatum is a common element of drug reward, but alcohol has an unusually complex pharmacology, and humans vary greatly in their alcohol responses. This variation is related to genetic susceptibility for alcoholism, which contributes more than half of alcoholism risk.

Here, we report that a functional
OPRM1 A118G polymorphism is a major determinant of striatal dopamine responses to alcohol. Social drinkers recruited based on OPRM1 genotype were challenged in separate sessions with alcohol and placebo under pharmacokinetically controlled conditions, and examined for striatal dopamine release using positron emission tomography and [11C]-raclopride displacement. A striatal dopamine response to alcohol was restricted to carriers of the minor 118G allele.

To directly establish the causal role of
OPRM1 A118G variation, we generated two humanized mouse lines, carrying the respective human sequence variant. Brain microdialysis showed a fourfold greater peak dopamine response to an alcohol challenge in h/mOPRM1-118GG than in h/mOPRM1-118AA mice.

OPRM1
A118G variation is a genetic determinant of dopamine responses to alcohol, a mechanism by which it likely modulates alcohol reward.

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Request Reprint E-Mail: markus.heilig@mail.nih.gov

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Monday, May 17, 2010

Is the Full Version of the AUDIT Really Necessary? Study of the Validity and Internal Construct of Its Abbreviated Versions



This study was aimed at assessing the psychometric qualities of the abbreviated versions of the Alcohol Use Disorders Identification Test (AUDIT-3, AUDIT-4, AUDIT-C, AUDIT-PC, AUDIT-QF, FAST, and Five-Shot) and at comparing them to the 10-item AUDIT and the CAGE in 2 samples of Brazilian adults.

The validity and internal consistency of the scales were assessed in a sample of 530 subjects attended at an emergency department and at a Psychosocial Care Center for Alcohol and Drugs. The Structured Clinical Interview for DSM-IV was used as the diagnostic comparative measure for the predictive validity assessment. The concurrent validity between the scales was analyzed by means of Pearson's correlation coefficient.

The assessment of the predictive validity of the abbreviated versions showed high sensitivity (of 0.78 to 0.96) and specificity (of 0.74 to 0.94) indices, with areas under the curve as elevated as those of the AUDIT (0.89 and 0.92 to screen for abuse and 0.93 and 0.95 in the screening of dependence). The CAGE presented lower indices: 0.81 for abuse and 0.87 for dependence. The analysis of the internal consistency of the AUDIT and its versions exhibited Cronbach's alpha coefficients between 0.83 and 0.94, while the coefficient for the CAGE was 0.78. Significant correlations were found between the 10-item AUDIT and its versions, ranging from 0.91 to 0.99. Again, the results for the CAGE were satisfactory (0.77), although inferior to the other instruments.

The results obtained in this study confirm the validity of the abbreviated versions of the AUDIT for the screening of alcohol use disorders and show that their psychometric properties are as satisfactory as those of the 10-item AUDIT and the CAGE.


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Request Reprint E-Mail: jcrippa@fmrp.usp.br


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Pharmacologic Dissociation Between Impulsivity and Alcohol Drinking in High Alcohol Preferring Mice



Impulsivity is genetically correlated with, and precedes, addictive behaviors and alcoholism. If impulsivity or attention is causally related to addiction, certain pharmacological manipulations of impulsivity and/or attention may affect alcohol drinking, and vice versa.

The current studies were designed to explore the relationship among impulsivity, drinking, and vigilance in selectively bred High Alcohol Preferring (HAP) mice, a line that has previously demonstrated both high impulsivity and high alcohol consumption. Amphetamine, naltrexone, and memantine were tested in a delay discounting (DD) task for their effects on impulsivity and vigilance. The same drugs and doses were also assessed for effects on alcohol drinking in a 2-bottle choice test.

HAP mice were subjected to a modified version of adjusting amount DD using 0.5-second and 10-second delays to detect decreases and increases, respectively, in impulsive responding. In 2 experiments, mice were given amphetamine (0.4, 0.8, or 1.2 mg/kg), naltrexone (3 and 10 mg/kg), and memantine (1 and 5 mg/kg) before DD testing. Another pair of studies used scheduled access, 2-bottle choice drinking to assess effects of amphetamine (0.4, 1.2, or 3.0 mg/kg), naltrexone (3 and 10 mg/kg), and memantine (1 and 5 mg/kg) on alcohol consumption.

Amphetamine dose-dependently reduced impulsivity and vigilance decrement in DD, but similar doses left alcohol drinking unaffected. Naltrexone and memantine decreased alcohol intake at doses that did not affect water drinking but had no effects on impulsivity or vigilance decrement in the DD task.

Contrary to our hypothesis, none of the drugs tested here, while effective on either alcohol drinking or impulsivity, decreased both behaviors. These findings suggest that the genetic association between drinking and impulsivity observed in this population is mediated by mechanisms other than those targeted by the drugs tested in these studies.


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Request Reprint E-Mail: ngrahame@iupui.edu


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Interactive Effects of Cumulative Stress and Impulsivity on Alcohol Consumption



Alcohol addiction may reflect adaptations to stress, reward, and regulatory brain systems. While extensive research has identified both stress and impulsivity as independent risk factors for drinking, few studies have assessed the interactive relationship between stress and impulsivity in terms of hazardous drinking within a community sample of regular drinkers.

One hundred and thirty regular drinkers (56M/74F) from the local community were assessed for hazardous and harmful patterns of alcohol consumption using the Alcohol Use Disorders Identification Test (AUDIT). All participants were also administered the Barratt Impulsiveness Scale (BIS-11) as a measure of trait impulsivity and the Cumulative Stress/Adversity Checklist (CSC) as a comprehensive measure of cumulative adverse life events. Standard multiple regression models were used to ascertain the independent and interactive nature of both overall stress and impulsivity as well as specific types of stress and impulsivity on hazardous and harmful drinking.

Recent life stress, cumulative traumatic stress, overall impulsivity, and nonplanning-related impulsivity as well as cognitive and motor-related impulsivity were all independently predictive of AUDIT scores. However, the interaction between cumulative stress and total impulsivity scores accounted for a significant amount of the variance, indicating that a high to moderate number of adverse events and a high trait impulsivity rating interacted to affect greater AUDIT scores. The subscale of cumulative life trauma accounted for the most variance in AUDIT scores among the stress and impulsivity subscales.

Findings highlight the interactive relationship between stress and impulsivity with regard to hazardous drinking. The specific importance of cumulative traumatic stress as a marker for problem drinking is also discussed.

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Request Reprint E-Mail: helen.fox@yale.edu


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Changes in Sensation Seeking and Risk-Taking Propensity Predict Increases in Alcohol Use Among Early Adolescents


Conceptual models implicating disinhibitory traits often are applied to understanding emergent alcohol use, but, little is known of how inter-individual changes in these constructs relate to increases in alcohol use in early adolescence.

The current study utilized behavioral and self-report instruments to capture the disinhibitory-based constructs of sensation seeking and risk-taking propensity to examine if increases in these constructs over time related to increases in early adolescent alcohol use.

Participants included a community sample of 257 early adolescents (aged 9 to 12) who completed a self-report measure of sensation seeking, a behavioral task assessing risk-taking propensity, and a self-report of past year alcohol use, at 3 annual assessment waves.

Both sensation seeking and risk-taking propensity demonstrated significant increases over time, with additional evidence that change in the behavioral measure of risk-taking propensity was not because of practice effects. Greater sensation seeking and greater risk-taking propensity demonstrated concurrent relationships with past year alcohol use at each assessment wave. Prospective analyses indicated that after accounting for initial levels of alcohol use, sensation seeking, and risk-taking propensity at the first assessment wave, larger increases in both constructs predicted greater odds of alcohol use at subsequent assessment waves.

Results indicate the role of individual changes in disinhibitory traits in initial alcohol use in early adolescents. Specifically, findings suggest it is not simply initial levels of sensation seeking and risk-taking propensity that contribute to subsequent alcohol use but in particular increases in each of these constructs that predict greater odds of use.

Future work should continue to assess the development of sensation seeking and risk-taking propensity in early adolescence and target these constructs in interventions as a potential means to reduce adolescent alcohol use.

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Request Reprint E-Mail: lmacpherson@psyc.umd.edu


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BME National Alcohol Workshop 6th July 2010



The Alcohol Improvement Programme (AIP) will be holding a national workshop on the 6th July to examine the needs of Black and Minority Ethnic (BME) groups in relation to alcohol-harm. The workshop in Peterborough will be based on the findings of a brief evaluation study conducted by the research team at the University of Middlesex and will cover:
  • Common problems experienced by BME Groups in relation to needs for service provision and responses to needs.
  • An overview of differences between Regions and between BME groups in the needs for service provision.
  • Describe best practice in relation to 'Equality Impact Assessments'.
  • Share good practice examples and learning from the field
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Seminar on Youth drinking and binge drinking, 25 February 2010


Summary report (PFD)

Presentations



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Control Yourself: Alcohol and Impulsivity



Impulsivity represents a complex, multifaceted construct with relevance to alcohol use, abuse, and dependence. Researchers are refining the definitions and assessment of different subtypes of impulsive behavior and relating these to the causes and consequences of alcohol-related behaviors and disorders.

A satellite symposium on alcohol and impulsivity was held at the 2009 convention of the Research Society on Alcoholism.

This article provides an overview of the rationale for the symposium, a synopsis of review and original research articles emanating from the symposium, and a description of the implications of the work and possible future research directions.


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Request Reprint E-Mail: marc.potenza@yale.edu


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Behavioral and Biological Indicators of Impulsivity in the Development of Alcohol Use, Problems, and Disorders



Alcohol use disorders (AUDs) are a devastating public health problem. The construct of impulsivity is biologically based and heritable, and its various dimensions are relevant for understanding alcohol use.

The goal of the current manuscript is to review recent behavioral and biological research examining various dimensions of impulsivity and their relation to AUDs from risk for initial use through dependence and relapse. Moreover, we also highlight key psychological variables including affective processes as they relate to current use and early indications of alcohol problems, as well as psychopathology, violence, and aggression in relation to AUDs.

Each section includes a critical summary and we conclude the review with future directions focused on issues relevant to measurement, causality, and intervention.

Throughout the review, we attempt to be as specific as possible about the dimensions of impulsivity being referenced, while attempting to draw parallels and highlighting differences as the existing literature allows.


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Request Reprint E-Mail: clejuez@psyc.umd.edu


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Acute Alcohol Effects on Inhibitory Control and Implicit Cognition: Implications for Loss of Control Over Drinking



Alcohol impairs inhibitory control, and it alters implicit alcohol cognitions including attentional bias and implicit associations. These effects are seen after doses of alcohol which do not lead to global impairments in cognitive performance.

We review studies which demonstrate that the effects of alcohol on inhibitory control are associated with the ability of alcohol to prime alcohol-seeking behavior.

We also hypothesize that alcohol-induced changes in implicit alcohol cognitions may partially mediate alcohol-induced priming of the motivation to drink.

Based on contemporary theoretical models and conceptualizations of executive function, impulsivity, and the motivational salience of alcohol-related cues, we speculate on other aspects of cognition that may underlie alcohol's effects on alcohol seeking.

Inconsistencies in existing research and priorities for future research are highlighted, including dose effects and the potential interactions between chronic heavy drinking and the acute effects of alcohol on these cognitive processes.


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Request Reprint E-Mail: mfield@liverpool.ac.uk


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Insight Into the Relationship Between Impulsivity and Substance Abuse From Studies Using Animal Models


Drug use disorders are often accompanied by deficits in the capacity to efficiently process reward-related information and to monitor, suppress, or override reward-controlled behavior when goals are in conflict with aversive or immediate outcomes.

This emerging deficit in behavioral flexibility and impulse control may be a central component of the progression to addiction, as behavior becomes increasingly driven by drugs and drug-associated cues at the expense of more advantageous activities.

Understanding how neural mechanisms implicated in impulse control are affected by addictive drugs may therefore prove a useful strategy in the search for new treatment options. Animal models of impulsivity and addiction could make a significant contribution to this endeavor.

Here, some of the more common behavioral paradigms used to measure different aspects of impulsivity across species are outlined, and the importance of the response to reward-paired cues in such paradigms is discussed.

Naturally occurring differences in forms of impulsivity have been found to be predictive of future drug self-administration, but drug exposure can also increase impulsive responding. Such data are in keeping with the suggestion that impulsivity may contribute to multiple stages within the spiral of addiction.

From a neurobiological perspective, converging evidence from rat, monkey, and human studies suggest that compromised functioning within the orbitofrontal cortex may critically contribute to the cognitive sequelae of drug abuse.

Changes in gene transcription and protein expression within this region may provide insight into the mechanism underlying drug-induced cortical hypofunction, reflecting new molecular targets for the treatment of uncontrolled drug-seeking and drug-taking behavior.


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Strain Differences in Behavioral Inhibition in a Go/No-go Task Demonstrated Using 15 Inbred Mouse Strains



High levels of impulsivity have been associated with a number of substance abuse disorders including alcohol abuse. Research has not yet revealed whether these high levels predate the development of alcohol abuse.

The current study examined impulsivity in 15 inbred strains of mice (A/HeJ, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6J, C57L/J, C58/J, CBA/J, DBA/1J, DBA/2J, NZB/B1NJ, PL/J, SJL/J, SWR/J, and 129P3/J) using a Go/No-go task, which was designed to measure a subject's ability to inhibit a behavior. Numerous aspects of response to ethanol and other drugs of abuse have been examined in these strains.

There were significant strain differences in the number of responses made during the No-go signal (false alarms) and the extent to which strains responded differentially during the Go and No-go signals (d'). The rate of responding prior to the cue did not differ among strains, although there was a statistically significant correlation between false alarms and precue responding that was not related to basal activity level. Interstrain correlations suggested that false alarms and rate of responding were associated with strain differences in ethanol-related traits from the published literature.

The results of this study do support a link between innate level of impulsivity and response to ethanol and are consistent with a genetic basis for some measures of behavioral inhibition.


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Exploring the role of positive and negative consequences in understanding perceptions and evaluations of individual drinking events


While research has established that drinking more alcohol is associated with experiencing more positive and negative alcohol-related consequences, less is known about how college students evaluate their drinking experiences. Evaluations of drinking events may vary with factors such as how much one drinks, which consequences one experiences, and the context (i.e., where and with whom) one drinks on a given occasion.

This research used daily data (Level 2: N = 166 students, 61% female; Level 1: N = 848 person drinking days) to explore the relationship between quantity of alcohol consumed and experience of specific domains of positive and negative consequences and to examine how the experience of specific consequences related to overall evaluation of the drinking experience.

Drinking on a given day was positively associated with experiencing more negative (social and personal) and more positive (image, fun/social, and relaxation) consequences. With respect to the formation of overall impressions, negative (social and personal) consequences were associated with less favorable evaluations whereas positive (image, fun/social, and relaxation) consequences were associated with more favorable evaluations of the drinking experience.

Indirect effects analyses suggested that consequences (negative personal, negative social, positive fun/social, and positive relaxation) significantly mediated the relationship between drinking and overall evaluation at the daily level.

These results underscore the importance of considering both positive and negative consequences in understanding students' choices to drink and how they evaluate their experiences.


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Alcohol dependent inpatients who receive general hospital care vs. detoxification in psychiatric care and alcohol problem 1 year later


The aims were to investigate differences between alcohol dependent inpatients who seek alcohol treatment and those who do not seek alcohol specific but general hospital treatment, and to investigate problem drinking 12 months after hospitalization.

Multivariate logistic regression analyses revealed that higher age, living alone, being employed, previous help-seeking, increased severity of dependence, increased adverse consequences from drinking and increased motivation were significant predictors of receiving alcohol detoxification vs. general hospital treatment. A composite assessment of motivation to change and to seek help was the strongest predictor of positive outcome 12 months later.

Alcohol dependent individuals who receive detoxification in psychiatric care have a more severe alcohol problem and fewer social resources than those treated in general hospitals. Interventions targeting at enhancing motivation to change and to seek help should be part of routine general hospital care and of detoxification treatment in psychiatric care.


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Preventing Mental, Emotional, and Behavioral Disorders Among Young People: Progress and Possibilities (2009)



Several decades of research have shown that the promise and potential lifetime benefits of preventing mental, emotional, and behavioral (MEB) disorders are greatest by focusing on young people and that early interventions can be effective in delaying or preventing the onset of such disorders. National priorities that build on this evidence base should include (1) assurance that individuals who are at risk receive the best available evidence-based interventions prior to the onset of a disorder and (2) the promotion of positive MEB development for all children, youth, and young adults.

A number of promotion and prevention programs are now available that should be considered for broad implementation. Although individuals who are already affected by a MEB disorder should receive the best evidence-based treatment available, interventions before the disorder occurs offer the greatest opportunity to avoid the substantial costs to individuals, families, and society that these disorders entail.

Most MEB disorders have their roots in childhood and youth. Among adults reporting a MEB disorder during their lifetime, more than half report the onset as occurring in childhood or adolescence. In any given year, the percentage of young people with these disorders is estimated to be between 14 and 20 percent. MEB issues among young people—including both diagnosable disorders and other problem behaviors, such as early drug or alcohol use, antisocial or aggressive behavior, and violence—have enormous personal, family, and societal costs. The annual quantifiable cost of such disorders among young people was estimated in 2007 to be $247 billion. In addition, MEB disorders among young people interfere with their ability to accomplish normal developmental tasks, such as establishing healthy interpersonal relationships, succeeding in school, and transitioning to the workforce. These disorders also affect the lives of their family members.

A 1994 report by the Institute of Medicine (IOM), Reducing Risks for Mental Disorders: Frontiers for Preventive Intervention Research, highlighted the promise of prevention. In response to a subsequently burgeoning research base and an increasing understanding of the developmental pathways that lead to MEB problems, the Substance Abuse and Mental Health Services Administration, the National Institute of Mental Health, the National Institute on Drug Abuse, and the National Institute on Alcohol Abuse and Alcoholism requested a study from the National Academies to review the research base and program experience since that time, focusing on young people. The Committee on the Prevention of Mental Disorders and Substance Abuse Among Children, Youth, and Young Adults was formed under the auspices of the Board on Children, Youth, and Families to conduct this review (see Box S-1 for the complete charge).

The 1994 IOM report reaffirmed a clear distinction between prevention and treatment. The current committee supports this distinction. The prevention of disability, relapse, or comorbidity among those with currently existing disorders are characteristics and expectations of good treatment. Although treatment has preventive aspects, it is still treatment, not prevention. The strength of prevention research using this concept of prevention, coupled with the need for focused research on risks prior to the onset of illness, warrants the field’s continued use of a typology focused on interventions for those who do not have an existing disorder. Interventions classified as universal (population-based), selective (directed to at-risk groups or individuals), or indicated (targeting individuals with biological markers, early symptoms, or problematic behaviors predicting a high level of risk) are important complementary elements of prevention. Going beyond the 1994 IOM report, we strongly recommend the inclusion of mental health promotion in the spectrum of mental health interventions. . . . . .



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