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Sunday, February 12, 2012

.Prostate Cancer Linked to Heavy Alcohol Intake

Heavy ethanol intake is associated with an increased risk of prostate cancer (PCa) among low-risk men with at least one prior negative prostate biopsy, investigators reported here at the annual Genitourinary Cancers Symposium. It also is associated with an elevated risk for high-grade PCa.

The findings emerged from a study of data from 6,729 men who had at least one on-study bipsy while participating in the REDUCE (Reduction by Dutasteride of Prostate Cancer Events) trial. Of these, 49% were moderate drinkers and 26% were heavy drinkers.

The researchers, led by Lionel L. Ba├▒ez, MD, of Duke University Medical Center in Durham, N.C., found that as ethanol intake increased, so did the risk for PCa overall and for high-grade disease. Dutasteride decreased overall PCa risk significantly by 27% and ethanol intake did not interfere with the risk-reducing effect of dutasteride.

Compared with non-drinkers, heavy drinkers had a 21% greater risk of PCa overall and a 34% greater risk of high-grade PCa (Gleason score of 7 or higher). > > > > Read More