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Monday, September 13, 2010

Does the transcription factor AP-2β have an impact on the genetic and early environmental influence on ethanol consumption?



Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2β.

In the present study, we investigated TFAP-2β protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2β levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption.

Taken together, we found differences in brainstem TFAP-2β protein between the AA and ANA rats.


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