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For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.
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For full versions of posted research articles readers are encouraged to email requests for "electronic reprints" (text file, PDF files, FAX copies) to the corresponding or lead author, who is highlighted in the posting.
___________________________________________
Saturday, July 24, 2010
A Variable-Number-of-Tandem-Repeats Polymorphism in the Dopamine D4 Receptor Gene Affects Social Adaptation of Alcohol Use
Research suggests that people adapt their own drinking behavior to that of other people.
According to a genetic-differences approach, some individuals may be more inclined than others to adapt their alcohol consumption level to that of other people.
Using a 3 (drinking condition) × 2 (genotype) experimental design (N = 113), we tested whether susceptibility to alcohol-related cues (i.e., seeing someone drink) was related to the variable number of tandem repeats in exon 3 of the D4 dopamine receptor gene.
A strong gene-environment interaction showed that participants carrying at least one copy of the 7-repeat allele consumed substantially more alcohol in the presence of a heavy-drinking individual than did participants without this allele.
This study highlights that individual variability in sensitivity to other people’s drinking behavior may be attributable to genetic differences.
Carrying the 7-repeat allele may increase the risk for heavy alcohol use or abuse in the company of heavy-drinking peers.
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Request Reprint E-Mail: h.larsen@pwo.ru.nl
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