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Thursday, February 11, 2010

Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology


Alcohol is frequently used in combination with 3,4-methylenedioxymethamphetamine (MDMA). Both drugs affect cardiovascular function, hydration and temperature regulation, but may have partly opposing effects.

The present study aims to assess the acute physiologic effects of (co-) administration of MDMA and ethanol over time.

Ethanol did not significantly affect physiologic function, with the exception of a short lasting increase in heart rate. MDMA potently increased heart rate and blood pressure and induced fluid retention as well as an increase in temperature.

Co-administration of ethanol with MDMA did not affect cardiovascular function compared to the MDMA alone condition, but attenuated the effects of MDMA on fluid retention and showed a trend for attenuation of MDMA-induced temperature increase.

In conclusion, co-administration of ethanol and MDMA did not exacerbate physiologic effects compared to all other drug conditions, and moderated some effects of MDMA alone.

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Request Reprint E-Mail: G.J.H.Dumont@psy.umcn.nl

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